The present investigation titled “Effect of organic and inorganic fertilizer on growth and yield of tomato under protected cultivation” was carried out during 2022 in Central Horticulture Research Farm of Department of Horticulture, SHUATS, Prayagraj to assess the impact of different doses of organic and inorganic fertilizer on the growth and yield of tomatoes under protected condition, as well as to analyze the economic aspects of different treatments. The experiment was conducted in Randomized Block Design with 10 treatments replicated thrice. The treatments were T0 Recommended dose of fertilizers (RDF), T1 75% (RDF) +25% (Vermicompost), T2 50% (RDF) + 50% (Vermicompost), T3 25% (RDF) +75% (Vermicompost), T4 75% (RDF) + 25% (FYM), T5 50 %(RDF) +50% (FYM), T6 25 %(RDF) +75% (FYM), T7 75% (RDF) + 25% (Poultry Manure), T8 50% (RDF) +50% (Poultry Manure), T9 25% (RDF) +75% (Poultry Manure). On the basis of our finding the best treatment was found to be T6 (25% RDF + 75% FYM) which was found best in terms of growth parameters and yield parameters among different treatment combinations of tomato. Also the best B:C ratio 3.84 was found in T6 (25% RDF + 75% FYM).