Due to their potential applications in physiological monitoring, diagnosis, human prosthetics, haptic perception, and human-machine interaction, flexible tactile sensors have attracted wide research interest in recent years. Thanks to the advances in material engineering, high performance flexible tactile sensors have been obtained. Among the representative pressure sensing materials, 2D layered nanomaterials have many properties that are superior to those of bulk nanomaterials and are more suitable for high performance flexible sensors. As a class of 2D inorganic compounds in materials science, MXene has excellent electrical, mechanical, and biological compatibility. MXene-based composites have proven to be promising candidates for flexible tactile sensors due to their excellent stretchability and metallic conductivity. Therefore, great efforts have been devoted to the development of MXene-based composites for flexible sensor applications. In this paper, the controllable preparation and characterization of MXene are introduced. Then, the recent progresses on fabrication strategies, operating mechanisms, and device performance of MXene composite-based flexible tactile sensors, including flexible piezoresistive sensors, capacitive sensors, piezoelectric sensors, triboelectric sensors are reviewed. After that, the applications of MXene material-based flexible electronics in human motion monitoring, healthcare, prosthetics, and artificial intelligence are discussed. Finally, the challenges and perspectives for MXene-based tactile sensors are summarized.