You have accessJournal of UrologyProstate Cancer: Detection and Screening V1 Apr 20122207 TOTAL SERUM TESTOSTERONE/PCA 3 RATIO: INCREASING THE PROSTATE BIOPSY YIELD Billy H. Cordon, Timothy C. Siegrist, Noel A. Armenakas, and John A. Fracchia Billy H. CordonBilly H. Cordon New York, NY More articles by this author , Timothy C. SiegristTimothy C. Siegrist New York, NY More articles by this author , Noel A. ArmenakasNoel A. Armenakas New York, NY More articles by this author , and John A. FracchiaJohn A. Fracchia New York, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2382AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Early detection of prostate cancer usually requires a prostate biopsy which is a generally safe and well tolerated but does have some associated morbidities. Both hypogonadism and elevated urinary Prostate Cancer Gene 3 (PCA3) levels have been associated with increased detection of prostate cancer. We sought to determine whether the ratio of total serum testosterone to PCA3 density might enhance the positive prostate biopsy yield of prostate cancer in a select population of men undergoing prostate biopsies for ‘abnormal’ serum prostate specific antigen (PSA) levels. METHODS The study population consisted of 177 men undergoing prostate biopsy between March 2008 to July 2011. Morning serum total Testosterone levels (T) were obtained on all men undergoing biopsy. PCA3 urinary levels were obtained after digital exam, immediately prior to twelve core ultrasound guided prostatic biopsy. PCA3 urinary level was divided by prostatic volume to obtain PCA3 density as PCA3 is representative of prostate cancer volume. Testosterone levels were converted from ng/dl to ng/ml by dividing by 100. This value was divided by PCA3 density to obtain the ratio of Testosterone to PCA 3 density. RESULTS Cancer was detected overall in 42 (24%) patients. Decreasing total serum Testosterone and increasing urinary PCA3 density were associated with an increased detection of prostate cancer. The Receiver Operating Characteristic (ROC) curve was analyzed for the ratio of Testosterone to PCA3 density. The area under the curve was 0.737 which was greater than that of serum Testosterone (0.631), PCA3 (0.719) and PCA3 density (0.734). CONCLUSIONS The ratio of testosterone to PCA3 density demonstrates an association with the results of prostate biopsy in our select group of men undergoing prostate biopsy. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e890 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Billy H. Cordon New York, NY More articles by this author Timothy C. Siegrist New York, NY More articles by this author Noel A. Armenakas New York, NY More articles by this author John A. Fracchia New York, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...