Purpose: Women’s leadership is a necessary step in the development of civilization. However, the purpose of this study is to identify the barriers and challenges facing Saudi Arabian women seeking leadership positions in the health care industry. Theoretical Framework: The model's constructs are based on the studies cited, and they include barriers related to culture, a woman's personality, organizational politics, women's empowerment, and male top management discrimination. Design/Methodology/Approach: The study used a survey to collect data from 459 female was chosen for the study and a sample comprised of female employees in the Saudi privet healthcare sector from all the regions in the Kingdom of Saudi Arabia.. Using smart PLS, was employed to analyses the research data. Findings: The findings and the results of the analysis indicates that the dimensions of the model included Male top management discrimination, Culture, woman’s personalities, and organizational politics exert different influences on women's empowerment. we find Measuring the effect of moderating factors (The Male top management discrimination) indicates has the strongest effect on Culture and women's empowerment in the Saudi healthcare sector. Research, Practical & Social Implications: As a result, this study has deepened our understanding of the dynamic nature of women's empowerment and the challenges facing women's prospects for leadership while also helping to reframe gender roles. According to this study, women should receive leadership training in order to improve their capacity for decision-making, fulfill their organizational obligations, and expand the opportunities for women's empowerment. Originality/Value: The degree to which Saudi citizens are willing to change their opinions of women's leadership and personalities; to end practices that support male dominance and oppression of women; to end discriminatory laws and policies that impede women's career advancement; and to place their faith in a woman's self-assurance and ability to make the right decisions and shoulder the responsibility in healing.