Science and Technology for Entrepreneurship (IbK) at the University of Muhammadiyah Makassar aims to improve the knowledge and skills of students who have started pioneering a product as a forerunner of independent business through the Student Creativity Program (PKM), and alumni are starting a new business (entrepreneurship), creating new entrepreneurs independently based science and technology and creating an entrepreneurial training methods suitable for the tenant. IbK activities take place during the first three years to build as many as 20 tenants consisting of the students who have EnterpreneurshipStudent Creativity Program (PKM-K) active students and alumni PKM-K, and, of the 20 tenants that have generated new independent entrepreneurs as many as five (5); among others: (1) The business of Fermented Milk (for health and cosmetics), (2) Shoes Sabbe / Silk Bugis, (3) Crackers Cassava and Banana, (4) Shredded Chilli, (5) Pin and Keychain. Specific targets to be achieved through IBK activities are spawned at least 5 participants IBK become new entrepreneurs based independent science and technology, at least 80% of participants prospective entrepreneurs first year to new entrepreneurs. Training Methods entrepreneurial knowledge in the form of lectures, training to improve product quality and improved packaging tenant.The Results of IbK in the first year of activities, namely; Enterprises of fruit and vegetable fermentation, Souvenir glass bamboo, Flowers Products Terrarium, fish fry and Miniature Boat Pinisi. Increasing the quantity and quality of production of the tenants have pushed their motivation to be more diligent in terms of marketing their products. There are two ways that do marketing tenanare included in the category of an Independent ie depending on the type of production the tenants, such as for the production of fermented milk and pin / key holder by way of order. As for the tenants who produce; Cassava crackers and bananas, chili, as well as silk shoes / sabbe consignment Keywords: Training, self-employment, production, marketing