Prospective Research Research Articles

Potential Role of Benzoic Acid and its Synthetic Derivatives to Alleviate Cancer: An Up-to-Date Review.

Unregulated cell division is one of the main causes of cancer. These cancerous cells negatively impact nearby healthy cells. Cancer can occur anywhere in the body. Normal cell division occurs when cells grow, reproduce, and divide as the body needs. As a normal cascade of cell growth and division, when the cells get damaged, they undergo death, and normal cells develop. However, sometimes, this process is not followed, and abnormal or damaged cells start to grow and multiply several times more than normal. This particular process may form the basis of cancer. There is a research gap in terms of identifying personalized synthetic anticancer therapy, which may be based on individual patient characteristics with an aim to optimize treatment efficacy and minimize adverse effects. While searching for new bioactive compounds, it has been observed that organic molecules with benzoic acid (BA) moiety possess significant anticancer potential. Several works of literature reported the use of BA from natural or synthetic sources to synthesize bioactive chemicals. It has been observed that several natural products also contain BA moiety, and the presence of this moiety is considered responsible for several important biological activities. Therefore, in order to chemically synthesize a wide variety of potent biologically active compounds, benzoic acid as a basic moiety in the form of a scaffold can be employed. Other synthetic compounds with BA scaffolds include furosemide, tetracaine, and bumetanide. The current article aims to focus on past and present work done on BA derivatives and to emphasize the molecular pathways involved in cancer treatment. The future prospects for research in this area are encouraging as researchers are striving to advance synthetic BA derivatives. This could possibly contribute to more efficient treatments and better results for cancer patients.

Modern ideas about the predictions of postpartum hemorrhage

Postpartum hemorrhage is currently a pressing problem. Its increasing incidence over time is observed not only in developing countries but also in countries with high levels of income and resources that significantly contribute to the development and functioning of the health system, which is the cause of scientific debate worldwide. The risk factors of postpartum hemorrhage include low hemoglobin level before birth, older maternal age, first birth, prolonged duration of the first and second stages of labor, high birth weight of the newborn, abnormal placentation, surgical vaginal birth, cesarean section, episiotomy, and placental defects. This review outlines the main risk factors of postpartum hemorrhage, displays new data on the relationship between types of assisted reproductive technologies and postpartum hemorrhage, and discusses prospects for research regarding the problem. A link between assisted reproductive technologies and postpartum hemorrhage elucidates the increase in the incidence of postpartum hemorrhage in developed countries. It is crucial to further research on obstetric risks following the use of assisted reproductive technologies and identify additional risk categories for complications to provide quality medical care and reduce maternal and perinatal losses.

Advances in Metabolic Engineering for the Accumulation of Astaxanthin Biosynthesis.

Astaxanthin, a lipophilic carotenoid renowned for itsstrong antioxidant activity, holds significant commercial value across industries such as feed, food, and cosmetics. Although astaxanthin can be synthesized through chemical methods, it may contain toxic by-products in the synthesized astaxanthin, limiting its application inmedicine or functional food. Natural astaxanthin can be extracted from algae, however, the cultivation cycle of algae is relatively longercompared to microorganisms. With the advancement of synthetic biology and metabolic engineering, the method of microbial fermentation has emerged asa promising strategy for the large-scale production of astaxanthin. This article provides a comprehensive overview of the research progress in astaxanthin biosynthesis, highlighting the use ofthe natural host Xanthophyllomyces dendrorhous, andthe heterologous hosts Yarrowia lipolytica and Saccharomyces cerevisiae. Additionally, future research prospects are also discussed.

Method of Maximizing F-Synergistic Value in IT Development Projects for Self-Managed Organizations

The article is devoted to the formulation of the method of maximizing the F-synergistic value of IT development projects of a project-oriented organization, which was developed within the syncretic methodology of project management. The application of the proposed method is considered in the field of IT development projects of organizations involved in infrastructure restoration projects of Ukraine. The directions of scientific research in the field of value-oriented project management are analyzed. The previously unsolved part of the scientific problem is highlighted. Objects of value analysis in a project-oriented organization carrying out IT development were identified, among which stellarator projects were highlighted. A model for determining the value of a separate component of the system is presented. The concept of F-synergistic value is defined. Such a value is proposed to be calculated through the aggregate value of three clusters that create synergistic effects both within themselves (first-order value) and among themselves (second-order value). The clusters included: "IT + people" cluster, "projects + operational activity" cluster, "methodology + environment" cluster. Models for determining the value of a separate cluster and the aggregate F-synergistic value are proposed. Variations in the selection of weighting factors for evaluating value criteria are considered. Within the syncretic methodology, a method of maximizing the F-synergistic value of IT development of a project-oriented company is proposed. The model of 27 scenarios of the dynamics of the change of the multipliers of synergy of three clusters is presented. In the corresponding tables for each scenario, a hypothesis is put forward regarding the reasons for such dynamics for each scenario, as well as a model of further IT development of a project-oriented company in response to such reasons. According to the results of the development of the method of maximizing the F-synergistic value of IT development projects of a project-oriented organization guided by syncretic methodology, directions for improving the activities of such organizations were determined. An extended SWOT analysis of the proposed method was conducted. Conclusions based on the research are formulated, prospects for further research in the chosen direction are outlined.

Transformation of Methods of Art Objects Using in Interior Design

The aim of the article is to identify and systematise the methods of using art objects in interior design, to analyse their transformation (from traditional to modern methods) with a focus on various aspects of the relationship between the spatial environment and fine art objects. Results. The research has shown that the transformation of the methods of using art objects (from traditional to modern innovative ones) provides endless opportunities for new methods and technologies of interior design with the use of art objects, which creates a harmonious object-spatial environment taking into account modern design trends. The analysis of art objects and the object-spatial environment revealed their interconnection in the following aspects: functional purpose, location conditions, types of fine art, spatial perception, reflection of the interior theme, integration with technology, and compliance with the principles and goals of sustainable development. The scientific novelty lies in the study, systematisation and analysis of the transformation of methods (from traditional to modern) of using art objects in interior design. Conclusions. The use of art objects in the interior is a complex multifunctional process that reflects a modern approach to the use of art works in the object-spatial environment to achieve a high artistic level in interior design. It has been found that art objects in the interior perform various functions, have certain visual forms of embodiment and create a harmonious aesthetic and meaningful space for living and working. In view of the development of the scientific and technological revolution, we see the prospects for further research in the analysis, systematisation and identification of modern methods transformation, including the identification of new aspects of the relationship between art objects and the subject-spatial environment based on the transformation of methods of using art works.

Research Status and Prospect of Rheology of Waxy Crude Oil

Research Status and Prospect of Rheology of Waxy Crude Oil

Robust Natural Light-Absorbable and -Degradable AIE Photosensitizers for Fluorescence Labeling and Efficient Photodynamic Eradication of Algal Pollutants.

Current water pollution caused by the excessive proliferation of harmful algae urges green methods that can efficiently utilize natural light to treat algal pollution. Herein, a series of aggregation-induced emission (AIE) photosensitizers that can efficiently harness sunshine were synthesized for the environmentally friendly and biocompatible treatment of algal pollution. By tuning the number of thiophene units and the electron conjugation degree, the photosensitizers' absorptions were broadened to cover the whole visible light range. The positive charges guided photosensitizers to aggregate on algal cell surfaces, resulting in a turn-on fluorescence signal and robust reactive oxygen species generation under sunshine, thereby achieving fluorescence labeling and photodynamic eradication of algae. The eradication outcomes demonstrated that the AIE photosensitizers significantly outperformed the commercial algaecide ALG. At 20 ppm photosensitizers, 90.4% and 94.2% killing rates were achieved for C. reinhardtii and C. vulgaris, respectively, 2.8- and 3.6-fold higher than those from the same concentration of ALG. Excellent performances in inhibiting algae growth were also verified with efficiency superior to that of ALG. Importantly, the photosensitizers can self-degrade into biocompatible fragments under irradiation to avoid secondary pollution. The developed photosensitizers that possess sunshine convertibility and degradability provide an efficient tool for algal treatment, showing broad research and application prospects.

Graph neural networks for electroencephalogram analysis: Alzheimer’s disease and epilepsy use cases

Electroencephalography (EEG) is widely used as a non-invasive technique for the diagnosis of several brain disorders, including Alzheimer’s disease and epilepsy. Until recently, diseases have been identified over EEG readings by human experts, which may not only be specific and difficult to find, but are also subject to human error. Despite the recent emergence of machine learning methods for the interpretation of EEGs, most approaches are not capable of capturing the underlying arbitrary non-Euclidean relations between signals in the different regions of the human brain. In this context, Graph Neural Networks (GNNs) have gained attention for their ability to effectively analyze complex relationships within different types of graph-structured data. This includes EEGs, a use case still relatively unexplored. In this paper, we aim to bridge this gap by presenting a study that applies GNNs for the EEG-based detection of Alzheimer’s disease and discrimination of two different types of seizures. To this end, we demonstrate the value of GNNs by showing that a single GNN architecture can achieve state-of-the-art performance in both use cases. Through design space explorations and explainability analysis, we develop a graph-based transformer that achieves cross-validated accuracies over 89% and 96% in the ternary classification variants of Alzheimer’s disease and epilepsy use cases, respectively, matching the intuitions drawn by expert neurologists. We also argue about the computational efficiency, generalizability and potential for real-time operation of GNNs for EEGs, positioning them as a valuable tool for classifying various neurological pathologies and opening up new prospects for research and clinical practice.

Temporality and delayed models as dynamic characteristics of happiness

The subject of the study is the dynamic characteristics of happiness. The theoretical aspects of highlighting the context of temporality in happiness research are highlighted. The importance of time perspective for understanding happiness as a sociocultural phenomenon, as well as subjective well-being, is considered. The characteristics of delayed models of happiness are highlighted, influencing the perception of current life as an approach to a happier future. The empirical basis of the study is the results of a sociological study of Russian residents aged 18-60 years (n=1170) using an online survey conducted in September 2024 in capital cities (Moscow, St. Petersburg), the regional center (Ekaterinburg) and cities of the Sverdlovsk region. The novelty of the study lies in the identification and comparison of subjective assessments of happiness in a time perspective, past – present – future, which made it possible to identify an inclined trajectory of assessment of subjective well-being. The assessment of life satisfaction as a whole is shown to shift to lower levels in comparison with the assessment of current happiness. A contradiction has been revealed between the expectation of a better future and the uncertainty in its implementation. The use of a generational approach made it possible to fix temporality in the context of the influence of age and life experience on the perception of happiness, generational inequality of happiness and the convergence of assessments of chronic and current happiness with increasing age. Prospects for research on the topic are identified related to the insufficiency of quantitative measurement of the dynamic characteristics of happiness and the possibilities of identifying narratives in describing the temporality of the life experience of happiness, including its deferred models.

Current status and prospects of research on main diseases of rubber trees

Current status and prospects of research on main diseases of rubber trees

Pharmacological Action and Research Progress of Taraxasterol.

Primarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes. The primary aim of this study is to thoroughly explore the diseasemodulating mechanisms and effects of taraxasterol. We endeavor to provide an exhaustive review of the experimental subjects, intervention components, distinct action modalities, contributing factors, and protein pathway expressions associated with taraxasterol, systematically represented via diagrams and tables. Such a schematic representation encourages a continued academic dialogue concerning taraxasterol's pharmacological characteristics. This review is envisioned as a practical guide for the selection of experimental subjects and methodologies in prospective research. It is intended to further illuminate taraxasterol's pharmacodynamics, thereby offering theoretical and empirical justification for its clinical application.

Functions and mechanisms of non-histone protein acetylation in plants.

Lysine acetylation, an evolutionarily conserved post-translational protein modification, is reversibly catalyzed by lysine acetyltransferases and lysine deacetylases. Lysine acetylation, which was first discovered on histones, mainly functions to configure the structure of chromatin and regulate gene transcriptional activity. Over the past decade, with advances in high-resolution mass spectrometry, a vast and growing number of non-histone proteins modified by acetylation in various plant species have been identified. Lysine acetylation of non-histone proteins is widely involved in regulating biological processes in plants such as photosynthesis, energy metabolism, hormone signal transduction and stress responses. Moreover, in plants, lysine acetylation plays crucial roles in regulating enzyme activity, protein stability, protein interaction and subcellular localization. This review summarizes recent progress in our understanding of the biological functions and mechanisms of non-histone protein acetylation in plants. Research prospects in this field are also noted.

The analysis of credit governance in the digital economy development under artificial neural networks

This paper aims to provide new avenues for innovation in credit governance in the digital economy to provide more reliable credit evaluation solutions for financial, commercial, and social interactions. This paper integrates the potential value of Internet of Things (IoT) technology in credit governance and proposes a credit governance method that utilizes IoT data and an improved Long Short-Term Memory model. The proposed model introduces an adaptive mechanism to monitor changes in data in real-time and automatically adjust network parameters to improve the model performance. Experimental validation is conducted on the University of California Irvine dataset. It is found that the proposed model performs well in terms of accuracy, F1 value, and Area Under the Curve value, with values of 0.9, 0.91, and 0.94, respectively. This indicates that the proposed model has higher classification accuracy and performance in classification tasks while maintaining efficient training time. This indicates that the presented method has potential application prospects in credit governance research.

Improvement of the system for creating intellectual property objects

The aim of this article is to identify the institutional and economic-psychological factors that affect the effectiveness of protecting intellectual property rights, with the goal of improving the efficiency of innovation in priority areas of scientific and technological development. In this study, we used methods of analysis, systematization, and classification to extract relevant information related to the efficiency of innovative activity from regulatory and academic sources. We also analyzed patent data for five years to track the dynamics of application filings and patent reviews. Additionally, we applied methods of functional analysis to labor functions in training future patent and economic engineers. Finally, we employed the methodology of expert evaluation to assess the rating of indicators for innovative performance. Based on a comprehensive analysis of normative and scientific approaches to evaluating the effectiveness of innovative activities, the main directions and ways to improve it have been identified, and prospects for future research have been outlined. The paper also discusses the activities of faculty and researchers, as well as the potential for further research in this area

Recent Patents for Optical Component Polishing Technology

Background: Fluid jet polishing, Airbag polishing, Magnetorheological polishing, and Ion beam polishing are all emerging polishing technologies commonly used for processing optical components, which can be used to manufacture various high-precision and high-quality optical components. Their processing mechanisms are to remove materials by high-speed jet impacting the surface of the workpiece; using a spherical flexible airbag as a polishing tool to obtain a super-smooth surface by adding polishing fluid containing fine abrasives; controlling the magnetic field to form a flexible polishing belt of Magnetorheological fluid, which undergoes relative motion to achieve material removal; using a neutral ion beam to bombard the surface of the workpiece to remove workpiece surface atoms and obtain a super-smooth surface through energy and momentum transfer between ions and workpiece atoms. The characteristics and removal mechanisms of various polishing methods are briefly described, and the advantages and key issues that need to be addressed for each polishing technology are pointed out, and suggestions and prospects for future research, application, and development are also given. Objective: In order to meet the growing demand for high-precision optical components and mass-manufactured optical components, this paper aims to study the various polishing technologies that are continuously improved and suggestions are made for future research and development directions. Method: This paper reviews the current patents related to various polishing technologies, such as Fluid jet polishing, Airbag polishing, Magnetorheological polishing and Ion beam polishing and other representative polishing technologies. Results: Various types of polishing technologies have been studied, and the main problem at the current stage is the lack of accuracy. The problem of the polishing device, such as fluid jet polishing, only considers the change of fluid velocity and pressure to construct the removal function model for analysis and summary, and suggestions for the latest research progress of various polishing technologies are given. Conclusion: The improvement and optimization of polishing technology are beneficial to improving the polishing accuracy and quality of optical components and have great help for the future development of related patents.

Experience of interdisciplinary projects implementation in the training of pre-serviced IT-specialists

Abstract The problems of contemporary IT specialists’ training in terms of the high requirements to their mathematical and computational thinking skills as well as the urgency of raising their motivation to mastering math and algorithmization are discussed in the paper. It is pointed out that initial university courses should involve the students in the experiences that focus pre-service IT-specialists on the deep understanding of a mathematical backround and an algorithmic nature of any coding task, demonstrate them the role of math in the analysis of algorithm characteristics, and importance of math knowledge in for successful IT-career. One of such experiences presented by the authors is involving the pre-service IT-specialists into the work upon the interdisciplinary projects. The said activity is elaborated basing on the core didactic principles of PBL with the focus on the interdisciplinary project peculiarities. The goal, stages and results of the said PBL are described and analyzed in terms of its impact on the students’ awareness of mathematical knowledge value in their vocational activity. The levels of of formation of the IT-specialists’ awareness of mathematical knowledge value are established and determined. The survey and monitoring program were developed and realized which showed the changes in the distribution of pre-service IT-specialists by the levels of the said awareness for their future IT career. The prospects of further research are outlined in terms of holding the empirical research for the verification of the offered PBL activity impact on the motivation to IT-specialists’ learning mathThe software module’s core components are distinguished and the set of requirements in terms of their design are formulated according to the logic of the components work.

Recent advances in the preservation effects of spice essential oils on fruits and vegetables

Spice essential oils (SEOs) are currently a prominent area of investigation in food preservation due to their natural, effective, and environmentally friendly properties. This review discussed the latest research progress concerning the application of SEO in fruits and vegetables preservation. The article commenced with an overview of the sources of SEOs and their main components, explored their bioactivities, antimicrobial mechanisms, and the microencapsulation and nanotechnology utilizing spice essential oils. Further research explored the applications of SEOs in culinary, pharmaceuticals, cosmetics, agriculture, and food industries, with a focus on evaluating their effectiveness in extending the shelf-life of fruits and vegetables. Additionally, it discusses limitations such as intense aroma and toxicity concerns, while also outlining prospects for future research and applications in the food sector. Overall, SEOs offer promising avenues for effectively prolonging the storage period of post-harvested fruits and vegetables while maintaining their quality attributes.

СУТЬ І СТРУКТУРА ЕКОНОМІЧНОЇ КУЛЬТУРИ МАЙБУТНІХ ТЕХНІКІВ З ТРАНСПОРТНИХ ТЕХНОЛОГІЙ ТА УПРАВЛІННЯ ПЕРЕВЕЗЕННЯМИ НА АВТОМОБІЛЬНОМУ ТРАНСПОРТІ

The relevance of the article is due to the need to define and substantiate the essence and structure of the economic culture of future technicians in transport technologies and transportation management in road transport, to reveal the content of each component of the structure of economic culture, as well as to determine the key factors that contribute to its formation in the process of professional training of future technicians in transport technologies technologies and management of road transport. The purpose of the article is to determine the essence and structure of the economic culture of future technicians in transport technologies and management of road transport. Methods: the study of scientific sources regarding the interpretation of the essence of the concept "economic culture of the culture of future technicians in transport technologies and management of transportation by road transport" - to formulate one's own views on defining the content of this phenomenon; structural-component analysis - to distinguish the components of the economic culture of future technicians in transport technologies and transportation management by road transport; generalization and systematization - and formulation of conclusions and prospects for further research. Results: the main approaches in scientific sources to the interpretation of the concept of "economic culture of future technicians in transport technologies and management of road transport" were determined; the main components of the structure of economic culture and the components of the formation of the economic culture of future technicians in transport technologies and management of road transport are characterized. Conclusions: the essence of the economic culture of future technicians in transport technologies and transportation management in road transport is an integrative formation of the personality of a specialist, reflecting a system of professionally important qualities, values, knowledge, abilities and skills in planning technologies for the organization of transportation, providing transport and warehouse services, using resource potential for development transport enterprises in market conditions; characterized by a high degree of discipline, responsibility, independence with an awareness of the priorities of economic culture in the performance of professional tasks. The component structure of the economic culture of technicians in transport technologies and transportation management in road transport includes motivational-value, innovative-cognitive, activity-technological, personal-reflexive.

Research progress and prospects of spraying of multi-rotor plant protection UAV

Research progress and prospects of spraying of multi-rotor plant protection UAV

Evaluation and Improvement of College Dance Course Based on Multiple Intelligences Theory

Based on the theory of multiple intelligences, this paper discusses the methods and strategies for the evaluation and improvement of college dance courses. Firstly, this paper introduces the concept and development of multiple intelligence theory and emphasizes its complement and perfection to traditional intelligence theory. Then, it analyzes the problems and shortcomings of current college dance courses, including overemphasis on skill training and single evaluation criteria. Then, it puts forward the curriculum evaluation index based on the theory of multiple intelligences, including the evaluation of students’ multiple intelligences development and the evaluation of curriculum design and teaching methods. At the same time, curriculum evaluation tools and methods are discussed, such as questionnaire survey, observation record, learning achievement display and student self-rating. In the aspect of curriculum improvement and perfection strategy, it emphasizes the application of multiple intelligence theory, interdisciplinary integration and the introduction of scientific and technological means. In terms of curriculum implementation and effect evaluation, the importance of students’ comprehensive intelligent evaluation and students’ feedback is emphasized. Finally, the paper summarizes the practical value of the evaluation and improvement of college dance courses based on the theory of multiple intelligences and looks forward to the future research direction and prospects.