Study objectiveA few randomized trials have compared LMA Supreme™ with LMA ProSeal™ and i-gel™ in children but their conclusions varied widely. This systematic review and meta analysis has compared the former device with the latter two devices. DesignMeta-analysis and systematic review using the Mantel-Haenszel method and pooled mean difference using inverse variance method. SettingMeta-analysis of published prospective randomized controlled trials. PatientsPaediatric patients undergoing surgery under general anaesthesia. InterventionLMA Supreme™ with LMA ProSeal™ or i-gel™ as airway management device. ResultsElectronic database searching revealed four randomized trials where LMA Supreme™ has been compared with LMA ProSeal™ and three trials where a comparison was made between LMA Supreme™ and i-gel™ in paediatric population. LMA Supreme™ provided similar oropharyngeal leak pressure when compared to LMA ProSeal™ [mean difference (95% CI) 1.57 (−1.33, 4.47)cm H2O; p=0.29] and i-gel™ [mean difference (95% CI) 1.18 (−2.11, 4.47)cm H2O; p=0.48]. First insertion success rate is also similar when LMA Supreme™ is compared to LMA ProSeal™ [RR (95% CI) 1.03 (0.97, 1.1); p=0.74] and i-gel™ [RR (95% CI) 0.99 (0.95, 1.03); p=0.51]. Device insertion is significantly faster with LMA Supreme™ than i-gel™ [mean difference (95% CI) 1.87 (0.93, 2.81) s; p<0.0001]. ConclusionWe suggest that LMA Supreme™ may be an alternative to LMA ProSeal™ and i-gel™ in children for airway management during general anaesthesia.