Propylene Glycol Research Articles

New Topical Treatment for Atopic Dermatitis

The primary approach for managing atopic dermatitis (AD) involves the use of topical corticosteroids as the first-line treatment.While high-potency topical corticosteroids have shown to be effective, they come with an increased risk of local and, rarely, systemic adverse effects. Additionally, patients often experience a relapsing and remitting course. A revolutionary topical treatment for psoriasis and AD has recently received patent approval from the Spanish Ministry of Industry, Trade, and Tourism. This innovative treatment, presented in the form of a lotion, includes a combination of clobetasol, papaverine hydrochloride, spironolactone, a milk-peptide complex, and propylene glycol. An 18-year-old female presented with AD on the back of her neck and scalp. The patient had no significant past medical history and primarily complained of intense pruritus in the AD lesions. The patient received guidance to apply our recently patented lotion, Psorisbye, once a day for 5 days. In total, 50 ml of Psorisbye was utilized over 4 days. On the fifth day, the patient underwent an examination at the outpatient clinic. The patient reported a significant improvement in pruritus sensations and observed a reduction in scaled lesions. Upon evaluating our patient, a comparison of the lesions before and after applying the topical treatment for 4 days revealed a notable improvement in the SCORAD index, decreasing from 49.95 to 0. While the results of Psorisbye in this case show promise, it is crucial to conduct further studies with larger sample sizes and extended follow-up periods to validate the findings presented in our case report.

Formulation and Characterization of Glucosamine Sulphate Potassium Chloride (GSPC) Loaded Emulgel for the Treatment of Osteoarthritis.

Osteoarthritis (OA) is becoming a major medical burden worldwide due to changing lifestyles and aging populations. Osteoarthritis is a disease characterized by a variety of anatomic and physiological changes to joints, including cartilage degradation, bone remodeling, and the formation of osteophytes. These changes cause pain, stiffness, swelling, and limitations in joint function. Glucosamine serves as a fundamental constituent for cartilage, the resilient connective tissue responsible for cushioning joints. Glucosamine Sulphate Potassium Chloride (GSPC) supplementation is widely employed to mitigate symptoms linked to osteoarthritis, a degenerative joint disorder hallmarked by cartilage degradation. Palliative care aims at minimizing pain and disability and improving function, performance, and quality of life. In this study, the emulgel formulation of GSPC was developed and checked for its potential. Currently, OA does not have a definitive treatment. Since conventional dosage forms cannot deliver the active drug content at a predefined target site in a predictable manner throughout the treatment period, a new carrier system is always required. Considering their reduced size, targeting potential, and site specificity, nanocarrier-based approaches could hold an answer to shortcomings associated with conventional routes. Thus, the objective of the current study was to formulate and characterize glucosamine sulphate potassium chloride-loaded emulgel for the treatment of osteoarthritis. Microemulsion of glucosamine sulphate potassium chloride was formulated using a spontaneous emulsification method comprising of oleic acid (oil phase), Tween 80, Tween 20 (surfactant) and PEG 400, Span 80 (co-surfactant), and distilled water (aqueous phase). The microemulsions were evaluated for surface morphology, globule size, poly-dispersibility index (PDI), zeta potential, and viscosity, and the final batch of microemulsions was selected. The optimized microemulsion contained 35% co-surfactant (propylene glycol), 20% surfactant (Tween 20), and 15% oil (oleic acid) and glucosamine sulphate potassium chloride in a dose of 60 mg, which has sufficient drug loading capacity with a droplet size of 182 nm for optimized formulation. The optimized microemulsion formulation was added to gel prepared by Carbopol 934 in a 1:1 (w/w) ratio, leading to the formulation of glucosamine sulphate potassium chloride- containing emulgel. The prepared emulgel was further evaluated for viscosity, drug content, pH, and in-vitro drug release. Emulgel formulation (F6) showed 88% drug release after 6 hours, and it followed the Higuchi model. Glucosamine Sulphate Potassium Chloride (GSPC) is used in the treatment of OA by increasing the production of proteoglycans, which can cause the cartilage to break down. Emulgel formulation (F3) showed 75.41% drug release, and formulation (F6) showed 88% drug release after 6 h. Therefore, it may be concluded that an emulgel of GSPC can be used as a controlled-release dosage form of the drug for local application in OA.

Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels.

Dendritic hydrogels based on carbosilane crosslinkers are promising drug delivery systems, as their amphiphilic nature improves the compatibility with poorly water-soluble drugs. In this work, we explored the impact of the complementary polymer on the amphiphilic properties of the dendritic network. Different polymers were selected as precursors, from the highly lipophilic propylene glycol (PPG) to the hydrophilic polyethylene glycol (PEG), including amphiphilic Pluronics L31, L35 and L61. The dithiol polymers reacted with carbosilane crosslinkers through UV-initiated thiol-ene coupling (TEC), and the resultant materials were classified as non-swelling networks (for PPG, PLUL31 and PLUL61) and high-swelling hydrogels (for PEG and PLUL35). The hydrogels exhibited thermo-responsive properties, shrinking at higher temperatures, and exhibited an intriguing drug release pattern due to internal nanostructuring. Furthermore, we fine-tuned the dendritic crosslinker, including hydroxyl and azide pendant groups in the focal point, generating functional networks that can be modified through degradable (ester) and non-degradable (triazol) bonds. Overall, this work highlighted the crucial role of the amphiphilic balance in the design of dendritic hydrogels with thermo-responsive behavior and confirmed their potential as functional networks for biomedical applications.

Closely Packed Core-Shell Micelle Structures of Double Hydrophilic Miktoarm Star Copolymers at the Air-Water Interface.

The aggregation behavior of amphiphilic block copolymers at the air-water interface has been extensively studied, but less attention was given to that of star copolymers. In this work, we studied the interfacial aggregation behavior of two double hydrophilic pH- and temperature-responsive miktoarm star copolymers of poly[di(ethylene glycol) methyl ether methacrylate]-poly[2-(dimethylamino)ethyl methacrylate] (PDEGMA3-PDMAEMA3 and PDEGMA4-PDMAEMA7, the subscripts denote arm numbers) with different molecular weights. The effects of subphase pH and temperature on the monolayer isotherms and hysteresis curves of the two star copolymers and the morphologies of their Langmuir-Blodgett (LB) films were studied by the Langmuir film balance technique and atomic force microscopy, respectively. At the air-water interface, the two star copolymers tend to form closely packed micelles. These micelles exhibit a core-shell structure, where the small hydrophobic core consists of cross-linker of ethylene glycol dimethacrylate (EGDMA) and the carbon backbones of PDEGMA and PDMAEMA arms and the short hydrophilic shell is composed of di(ethylene glycol) and tertiary amine side groups. With increasing subphase pH, the surface pressure versus molecular area isotherms shift toward larger mean molecular areas as a result of the enhanced interface adsorption of nonprotonated tertiary amine groups. The isotherm shift of PDEGMA3-PDMAEMA3 monolayers is primarily attributed to high density of tertiary amine groups in the shells, while that of PDEGMA4-PDMAEMA7 is mainly attributed to high density of di(ethylene glycol) groups in the shells. The hysteresis degrees in the monolayers of the two copolymers under alkaline and neutral conditions are greater than those under acidic conditions due to the decreased protonation degree of the tertiary amine groups. At 10 °C, the mobility of the shells is poor and the isotherms are located on the right. Above the lower critical solution temperature, di(ethylene glycol) groups contract, which causes a slight shift of the isotherms toward smaller mean molecular areas.

Influence of Polymer Side Chain Size and Backbone Length on the Self-Assembly of Supramolecular Polymer Bottlebrushes.

Hydrogen bonds are a versatile tool for creating fibrous, bottlebrush-like assemblies of polymeric building blocks. However, a delicate balance of forces exists between the steric repulsion of the polymer chains and these directed supramolecular forces. In this work we have systematically investigated the influence of structural parameters of the attached polymers on the assembly behaviour of benzene trisurea (BTU) and benzene tris(phenylalanine) (BTP) conjugates in water. Polymers with increasing main chain lengths and different side chain sizes were prepared by reversible addition-fragmentation chain-transfer (RAFT) polymerization of hydroxyethyl acrylate (HEA), tri(ethylene glycol) methyl ether acrylate (TEGA) and oligo(ethylene glycol) methyl ether acrylate (OEGA). The resulting structures were analyzed using small angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). Both BTU and BTP formed fibres with PHEA attached, but a transition to spherical morphologies was observed at degrees of polymerisation (DP) of 70 and above. Overall, the main chain length appeared to be a dominating factor in inducing morphology transitions. Increasing the side chain size generally had a similar effect but mainly impeded any aggregation as is the case of POEGA. Interestingly, BTP conjugates still formed fibres, suggesting that the stronger intermolecular interactions can compensate partially for the steric repulsion.

Enhancing the functionality of pea proteins by conjugation with propylene glycol alginate via transacylation reaction assisted with ultrasonication

Pea proteins lack the desirable functional characteristics for food and beverage applications. In this study, transacylation reaction assisted with ultrasonication was used to glycate pea proteins with propylene glycol alginate to enhance their functional properties. The reaction was carried out at pH 11.0 for different pea protein isolate: propylene glycol alginate mass ratios and time durations in a sonic bath at 40 °C. Glycation was confirmed in gel electrophoresis, and ultrasonication enhanced the glycation, with optimal degrees of glycation observed at 45 min reaction time and mass ratios of 2:1 (37.73%) and 1:1 (35.96%). The transacylation reaction increased random coil content of pea proteins by 28% and enhanced their solubility by 2.02 times at pH 7.0, water holding capacity by >50% at pH 7.0, foaming properties, emulsifying properties, and heat stability. This study offers a novel approach that can enhance functionality and applicability of pea proteins.

UNSATURATED POLYESTER RESIN BASED COMPOSITES: A CASE STUDY OF LIGNIN VALORISATION

Materials from green resources boast a low carbon footprint, forming the foundation of the circular economy approach in materials science. Thus, in this study, waste poly(ethylene terephthalate) (PET) was subjected to depolymerization using propylene glycol (PG), and subsequent polycondensation with bio-based maleic anhydride (MA) produced unsaturated polyester resin (b-UPR). Bio-derived acryloyl-modified Kraft lignin (KfL-A) served as a vinyl reactive filler in the b-UPR matrix to create b-UPR/KfL-A composites. The structural characterization of KfL-A and b-UPR involved the use of FTIR and NMR techniques. The mechanical properties of the newly fabricated composites were assessed through tensile strength, Vickers microhardness, and dynamic mechanical tests. The addition of KfL-A to the rigid b-UPR matrix enhanced material flexibility, resulting in less stiff and hard materials while preserving composite toughness. For instance, incorporating 10 wt.% of KfL-A in b-UPR led to a 17% reduction in hardness, a 48% decrease in tensile strength, and a 20% reduction in toughness. Positive environmental impact was achieved by incorporation of 64 wt.% of renewable and recycled raw material. Analogously prepared b-UPR/KfL composites showed structural inhomogeneity and somewhat better mechanical properties. Transmission (TEM) and scanning (SEM) electron microscopies revealed a suitable relationship between mechanical and structural properties of composites in relation to the extent of KfL-A addition. The UL94V flammability rating confirmed that flame resistance increased proportionally with the KfL-A addition. Once deposited in a landfill, these composites are expected to disintegrate more easily than PET, causing less harm to the environment and contributing to sustainability in the plastics cycle.

Fabrication and Synthesis of Thiococlchicoside Loaded Matrix Type Transdermal Patch.

The goal of this work was to synthesize and fabricate matrix type transdermal patches based on a combination of polymers (Eudragit L100, HPMC and PVP K30), plasticizer and crosslinking agents (propylene glycol and triethyl citrate) and adhesives (Dura Tak 87-6908) to increase Thiocolchicoside (THC) absorption via topical route. This method allows avoidance of first-pass metabolism along with a consistent and extended duration of therapeutic activity. Fabrication and casting of polymeric solutions containing THC was done either in petri plates or through lab coater to get transdermal patches. Finally, the formulated patches were studied for their physicochemical and biological evaluation using scanning electron microscopy, FTIR, DSC, XRD and ex-vivo permeation studies using pig ear skin. FTIR studies confirm that the THC characteristics peaks (carbonyl (Amide I) at 1525.5 cm-1, C=O stretching (tropane ring) at 1664.4 cm-1, Amide II band (N-H stretching) at 3325.9 cm-1, thioether band at 2360.7 cm-1, and OH group stretching band at 3400.2 cm-1) are still present in the polymer mixture even after formulation as a transdermal patch, indicating compatibility among all excipients. While on the other hand, DSC studies confirm endothermic peaks for all the polymers along with THC with the highest enthalpy of 65.979 J/g, which is an indicator of sharp endothermic peak at 198°C, leading to the melting of THC. The percentage drug content and percentage moisture uptake of all the formulation was found in the range of 96 ± 2.04 to 98.56 ± 1.34% and 4.13 ± 1.16 to 8.23 ± 0.90%, respectively. Drug release and release kinetics studies confirm that it is dependent on the composition of individual formulation. All these findings support the possibility of using suitable polymeric composition, as well as proper formulation and manufacturing circumstances, to create a one-of-a-kind technology platform for transdermal drug administration.

Reviewing the evidence of antimicrobial activity of glycols.

In the 1940s and 1950s, researchers seeking safe and novel ways to eliminate airborne pathogens from enclosed spaces, investigated glycol vapours as a method of disinfection. More recently, the COVID-19 pandemic highlighted the need for a non-toxic aerial disinfectant that can be used in the presence of people. This scoping review is intended to analyse the early and more recent literature on glycol disinfection, scrutinizing the methodologies used, and to determine if the use of glycols as modern-day disinfectants is justified PRISMA-ScR guidelines were used to assess the 749 articles retrieved from the Web of Science platform, with 46 articles retained after the search strategy was applied. Early studies generally demonstrated good disinfection capabilities against airborne bacteria and viruses, particularly with propylene glycol (PG) vapour. Vapour pressure, relative humidity, and glycol concentration were found to be important factors affecting the efficacy of glycol vapours. Contact times depended mainly on the glycol application method (i.e. aerosolization or liquid formulation), although information on how glycol efficacy is impacted by contact time is limited. Triethylene glycol (TEG) is deemed to have low toxicity, carcinogenicity, and mutagenicity and is registered for use in air sanitization and deodorization by the US Environmental Protection Agency. Glycols are also used in liquid formulations for their antimicrobial activity against a wide range of microorganisms, although when used as a non-active excipient in products, their contribution to antimicrobial efficacy is rarely assessed. The appropriate use of liquid glycol-containing formulations was found to positively impact the antimicrobial capabilities of disinfectants when used at temperatures <0, food preservatives, and dental medicaments. Providing modern delivery technology can accurately control environmental conditions, the use of aerosolized glycol formulations should lead to successful disinfection, aiding infection prevention, and control regimens.

Effect of Bimetallic Co-Cu/Dolomite Catalyst on Glycerol Conversion to 1,2-Propanediol

This present study examines the efficacy of using dolomite (Dol, CaMg(CO3)2)-supported copper (Cu) and cobalt (Co) bimetallic and monometallic catalysts for the hydrogenolysis of glycerol to propylene glycol (PG; 1,2-PDO). The proposed catalysts were generated using the impregnation process before they were calcined at 500°C and reduced at 600°C. Advanced analytical techniques namely Brunauer, Emmett, and Teller (BET) method; the Barrett, Joyner, and Halenda (BJH) method; temperature-programmed desorption of ammonia (NH3–TPD), hydrogen-temperature programmed reduction (H2-TPR), X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM) were then used to characterise the synthesised catalysts, whose performance was then tested in the hydrogenolysis of glycerol. Of all the synthesised catalysts tested in the hydrogenolysis process, the Co-Cu/Dol bimetallic catalyst performed best, with an 80.3% glycerol conversion and 85.9% PG selectivity at a pressure of 4 MPa, a temperature of 200°C, and a reaction time of 10 hours. Its high catalytic performance was attributed to effective interactions between its Co-Cu-Dol species, which resulted in acceptable acidity, good reducibility of metal oxide species at low temperatures, larger surface area (15.3 m2 g-1), large-sized particles, fewer pores (0.032 cm3 g-1), and smaller pore diameter (0.615 nm).

Fabrication and Characterization of Non-Conventional Starch Based Biofilms Employing Different Plasticizers

Increasing stress on environmental awareness has promoted the use of alternative strategies for common petrochemical based plastic sources to environmentally friendly biofilms and packaging materials. Food by products and underutilised indigenous plants sources are rich in biopolymers which can naturally decompose. The present study focusses on preparations of bioplastics from unconventional starch sources of litchi seed and churkha tuber as novel initiative to combat environmental pollution along with valorisation of undervalued plant sources and agrobased wastes. Ternary blend films of poly vinyl alcohol, starch, plasticizers like (glycerol, sorbitol, mannitol, propylene glycol, polyethylene glycol), citric acid prepared by casting technique produced best result. Comparative study of test samples (TH11, TH12, TH13, TH14 etc) with standardized thin films (TH1, TH2, TH3 etc.) showed variation in appearance, water activity, thickness, since the starch differ in their compositions, gelatinization and gelation time and temperature. High amylose containing litchi seed starch forms firm and more flexible films in comparison to low amylose containing churkha tuber starch. Maximum hygroscopicity was recorded in case of TH1 (77.4%) while thickness was maximum in case of TH12 (0.18 mm). Micro structural analysis clearly showed the nature of crosslinking between starch molecule and different plasticizers. The sensory analysis of food packed with the best among the formularized thin films showed mild change in taste while the other parameters remain same as normal. Better acceptability was in case of TH12 wrapped food rather than TH1. Thus, fabrication of biodegradable packaging is considered as the most sustainable alternative for food preservation. Int. J. Appl. Sci. Biotechnol. Vol 12(1): 29-38.

Cryopreservation of European flat oyster (Ostrea edulis) larvae using a controlled-rate freezer

Larvae of the European flat oyster (Ostrea edulis) were cryopreserved using two protocols originally developed for other bivalvian species with several modifications. Culture of the European flat oyster went through several setbacks due to parasitic diseases, thus, assisted reproductive technologies such as larval cryopreservation can aid in prompt restoration of lost populations and thus facilitate farming of the species. Veliger larvae were diluted in two basic extenders (0.4 M trehalose or 0.4 M sucrose) supplemented with ethylene glycol (EG), dimethyl-sulfoxide (DMSO) or propylene glycol (PG) in concentrations of 10–20% with or without the addition of polyvinylpyrrolidone (average MW-40,000; PVP-40). Larvae were loaded into 0.25-ml or 0.5-ml straws and cryopreserved in a controlled-rate freezer using two slow cooling profiles. Assessment of larval survival 20 min or 24 h post-thaw revealed that the cooling profiles and the type of extender used did not have a significant effect on survival rates. On the other hand, the type of cryoprotectant, straw volume and the time of assessment had a significant main effect on larval survival percentages (p < 0.001 in all three cases). Survival percentages of 70–80% were observed 20 min post-thaw which decreased to 40–60% at 24 h. Generally, EG and DMSO resulted in higher post-thaw larval survival than did PG when larvae were cryopreserved in 0.25-ml straws, whereas, these differences were not detected when 0.5-ml straws were employed. Results of these experiments will allow later studies on long-term survival of cryopreserved European flat oyster larvae.

Constructing the Polymer Molecules to Regulate the Electrode/Electrolyte Interface to Enhance Lithium-Metal Battery Performance.

Lithium-ion batteries, with high energy density and long cycle life, have become the battery of choice for most vehicles and portable electronic devices; however, energy density, safety and cycle life require further improvements. Single-functional group electrolyte additives are very limited in practical applications, a ternary polymer bifunctional electrolyte additive copolymer (acrylonitrile-butyl hexafluoro methacrylate- poly (ethylene glycol) methacrylate- methyl ether) (PMANHF) was synthesized by free radical polymerization of acrylonitrile, 2, 2, 3, 4, 4, 4-hexafluorobutyl methacrylate and poly (ethylene glycol) methyl ether methacrylate. A series of characterizations show that in Li metal anodes, the preferential reduction of PMANHF is conducive to the formation of a uniform and stable solid electrolyte interphase layer, and Li deposition is uniform and dense. At the NCM811 cathode, a film composed of LiF- and Li3N-rich is formed at the cathode-electrolyte interface, mitigating the side reaction at the interface. At 1.0 mA cm-2, the Li/Li cell can be stabilized for 1000 cycles. In addition, the Li/NCM811 cell can stabilize 200 cycles with a cathode capacity of 153.7 mAh g-1, with the capacity retention of 89.93 %, at a negative/positive capacity ratio of 2.5. This study brings to light essential ideas for the fabrication of additives for lithium-metal batteries.

Enhanced Catalytic Conversion of Disaccharides to Propylene Glycol Using Metal-Supported Graphitic Carbon Nitride

Enhanced Catalytic Conversion of Disaccharides to Propylene Glycol Using Metal-Supported Graphitic Carbon Nitride

Nanonization and Deformable Behavior of Fattigated Peptide Drug in Mucoadhesive Buccal Films.

This study was tasked with the design of mucoadhesive buccal films (MBFs) containing a peptide drug, leuprolide (LEU), or its diverse nanoparticles (NPs), for enhanced membrane permeability via self-assembled nanonization and deformable behavior. An LEU-oleic acid conjugate (LOC) and its self-assembled NPs (LON) were developed. Additionally, a deformable variant of LON (d-LON) was originally developed by incorporating l-α-phosphatidylcholine into LON as an edge activator. The physicochemical properties of LON and d-LON, encompassing particle size, zeta potential, and deformability index (DI), were evaluated. MBFs containing LEU, LOC, and NPs (LON, d-LON) were prepared using the solvent casting method by varying the ratio of Eudragit RLPO and hydroxypropyl methylcellulose, with propylene glycol used as a plasticizer. The optimization of MBF formulations was based on their physicochemical properties, including in vitro residence time, dissolution, and permeability. The dissolution results demonstrated that the conjugation of oleic acid to LEU exhibited a more sustained LEU release pattern by cleaving the ester bond of the conjugate, as compared to the native LEU, with reduced variability. Moreover, the LOC and its self-assembled NPs (LON, d-LON), equivalent to 1 mg LEU doses in MBF, exhibited an amorphous state and demonstrated better permeability through the nanonization process than LEU alone, regardless of membrane types. The incorporation of lauroyl-L-carnitine into the films as a permeation enhancer synergistically augmented drug permeability. Most importantly, the d-LON-loaded buccal films showed the highest permeability, due to the deformability of NPs. Overall, MBF-containing peptide NPs and permeation enhancers have the potential to replace parenteral LEU administration by improving LEU druggability and patient compliance.

Hydrogenolysis of glycerol without external H2 over Nb-doped Ni catalysts supported on ordered mesoporous alumina

The correlation between the physico-chemical properties of Nb-doped nickel supported on ordered mesoporous alumina catalysts and product distribution during hydrogenolysis of glycerol with in situ produced hydrogen in continuous was investigated. The synthesis of alumina was carried out by the evaporation induced self-assembly (EISA) method. To achieve different interaction strengths among Ni, Nb and Al, the catalysts were prepared by co-impregnation of Ni and Nb on alumina, successive impregnation on alumina, and Ni impregnation on Nb-modified alumina using a Ni/Nb atom ratio of 2. Catalytic runs were performed at 235 ºC/ 45 bar for 30 h TOS, at 12.2 h−1 WHSV.All the catalysts showed high carbon yields to liquid products, mainly 1,2-propylene glycol and hydroxyacetone. The NiNb-SI catalyst, prepared through sequential impregnation of Nb and Ni, demonstrated the highest initial glycerol conversion rate (69.3%) and stability over 30 h TOS. Furthermore, it produced the highest carbon selectivity for propylene glycol at 56.7%. The catalytic performance of NiNb-SISi was also assessed under the same conditions with the addition of hydrogen, resulting in an enhanced capacity for dehydration-hydrogenation. However, glycerol conversion decreased. Post-reaction characterization revealed that catalyst deactivation was primarily caused by leaching, sintering and oxidation of Ni.

OPTIMASI FORMULA DAN UJI EVALUASI FISIK SEDIAAN ESSENCE KOMBUCHA DENGAN VARIASI KONSENTRASI PROPYLENGLIKOL DAN GLISERIN

Skin problems can be treated with several cosmetic products such as essence. Essence is a skin care product that is part of skincare. Essence is a cosmetic product that has added value and optimal effects, namely as a humectant, ultraviolet protector, whitening agent, antioxidant, anti-inflammatory and skin rejuvenator. This Research using experimental method and aims to determine the optimal concentration of propylene glycol and glycerin in the optimum preparation of kombucha essence. In the results of the SLD method, 28 solutions were obtained, then for formula optimization the composition ratio between Propylene glycol and Glycerin was chosen as 11.5: 8.25 with a desirability value of 1.00. The resulting predicted values ​​are a pH test of 5.255 and a viscosity test of 546.7. The analysis used a parametric sample t-test which showed that the results were not significantly different. This is shown by the value (p&gt;0.05), so the results above indicate that the kombucha essence formula before and after the stability test was carried out obtained stable pH and viscosity values ​​during storage based on the parametric sample t-test. The research results showed that the essence preparation made had an optimal formula in formula 3, namely transparent white, had a pH within the range so it was safe for the skin, was homogeneous and a viscosity value of 528.7 cp.

Analysis of factors affecting the formation characteristics of carbon dioxide hydrates in pure water system

As the oilfield fully enters the late stage of exploitation, the water content in the oil and gas transportation pipelines is rising. Meanwhile, the high-pressure and low-temperature environment inside the pipeline facilitate the formation of hydrates, which will seriously block the mixing pipeline and cause a series of production safety problems. Therefore, it is necessary to control the risk under the high water content system. In this paper, a high-pressure flow loop device with a viewable window was used to study the formation characteristics of carbon dioxide hydrate in a pure water system, and the effects of the liquid loading, pressure, volume flow rate, and two inhibitors, polyvinylpyrrolidone (PVP) and propylene glycol methyl ether (PM), on the induction time of carbon dioxide hydrate formation were investigated. The experimental results showed that the amount of liquid loading, pressure, volume flow rate, and inhibitor had a significant effect on the hydrate induction time. In addition, the ether compounds PM and PVP have inhibitory synergistic effects, which can significantly prolong the hydrate induction time, and the inhibitory synergistic effect is further enhanced with the increase of PM concentration, which further suggests the synergistic inhibition mechanism of the two. Based on the standard regression coefficient method, the factors affecting the induction time were subjected to sensitivity analysis, and it was found that the inhibitor was the most important factor affecting the induction time. Therefore, future research should also focus on finding better performance of inhibitors, synergists and their ratio.

In-vitro Analysis of Antioxidant, Anti-inflammatory, Antidiabetic and Antimicrobial Studies of Kaempferol Ethosomes

Flavonoids have potent antioxidant, anti-inflammatory, antidiabetic and antimicrobial properties, and they generally report to have poor bioavailability and dissolution. This work emphasized on developing and characterizing kaempferol-loaded ethosomes and evaluating them for in-vitro assessments. The cold method was used for preparing kaempferol (KMP) ethosomes by means of soya lecithin, ethanol, and propylene glycol. The ethosomes were evaluated for vesicle size (253 ± 2.6), entrapment efficiency (91.05 ± 0.11%), zeta potential (-31.7 ± 1.12 mV), and drug release (89.91 ± 3.3%), compared with the release of pure drug (kaempferol), which was 48.96 ± 3.6% and showed an approximate double increment in the release rate. KMP ethosomes follow the Korsmeyer-Peppas model. The kaempferol ethosomes were further examined for their various in-vitro pharmacological activities as antimicrobial, anti-inflammatory, antidiabetic, and antioxidant in comparison with pure kaempferol. The results reported kaempferol loaded-ethosomes showed a strong anti-inflammatory, antimicrobial, antioxidant, and antidiabetic properties and thus, can be exploited as a viable drug delivery for various therapeutic applications.

Effects of vehicles on the physical properties and biocompatibility of premixed calcium silicate cements.

Premixed calcium silicate cements (pCSCs) contain vehicles which endow fluidity and viscosity to CSCs. This study aimed to investigate the effects of three vehicles, namely, polyethylene glycol (PEG), propylene glycol (PG), and dimethyl sulfoxide (DMSO), on the physicochemical properties and biocompatibility of pCSCs. The setting time, solubility, expansion rate, and mechanical strength of the pCSCs were evaluated, and the formation of calcium phosphate precipitates was assessed in phosphate-buffered saline (PBS). The effects of pCSC extracts on the osteogenic differentiation of mesenchymal stem cells (MSCs) were investigated. Finally, the tissue compatibility of pCSCs in rat femurs was observed. CSC containing PEG (CSC-PEG) exhibited higher solubility and setting time, and CSC-DMSO showed the highest expansion rate and mechanical strength. All pCSCs generated calcium phosphate precipitates. The extract of CSC-PG induced the highest expressions of osteogenic markers along with the greatest calcium deposites. When implanted in rat femurs, CSC-PEG was absorbed considerably, whereas CSC-PG remained relatively unaltered inside the femur.