In this paper, a different technique to predict the effects of soil-structure interaction (SSI) on seismic response of building systems is investigated. The technique use a machine learning algorithm called Support Vector Regression (SVR) with technical and analytical results as input features. Normally, the effects of SSI on seismic response of existing building systems can be identified by different types of large data sets. Therefore, predicting and estimating the seismic response of building is a difficult task. It is possible to approximate a real valued function of the seismic response and make accurate investing choices regarding the design of building system and reduce the risk involved, by giving the right experimental and/or numerical data to a machine learning regression, such as SVR. The seismic response of both single-degree-of-freedom system and six-storey RC frame which can be represent of a broad range of existing structures, is estimated using proposed SVR model, while allowing flexibility of the soil-foundation system and SSI effects. The seismic response of both single-degree-of-freedom system and six-storey RC frame which can be represent of a broad range of existing structures, is estimated using proposed SVR model, while allowing flexibility of the soil-foundation system and SSI effects. The results show that the performance of the technique can be predicted by reducing the number of real data input features. Further, performance enhancement was achieved by optimizing the RBF kernel and SVR parameters through grid search.