The aim of the present study was to investigate the profile of hospital morbidity and mortality due to COPD in Brazil between 2011 and 2021, in order to understand the evolution of related health indicators and identify the need for improvement in public policies for prevention and treatment strategies. for the disease. From the processed information, a significant decrease in the prevalence of hospitalizations for COPD was evidenced. The age groups that represented the highest numbers of hospitalizations were “50 years or older” and “under 5 years”. Proportional mortality declined, while COPD-specific mortality did not change statistically significantly over the entire decade. Mortality showed an increasing pattern according to age group, with more than 40% of deaths occurring in individuals aged 80 years or older. The highest numbers of hospitalizations and deaths occurred in the Southeast, South and Northeast regions, with a predominance of males. COPD is a problem that requires greater attention from health services, because despite the decrease in hospitalizations due to exacerbations, severe forms of the disease are still frequent, which highlights weaknesses in the primary and secondary prevention of the disease. Thus, new studies that extensively investigate the factors that determine the epidemiological behavior of the disease are fundamental, because only in this way can strategies and interventions be developed to improve trends in hospitalization and mortality due to COPD in Brazil.