This paper puts forward the microscopic chaos control in the deterministic dynamics of the chemical reactor system. First, the dynamic behavior of the chemical reactor system is explored for some of the parameters and chaotic behavior is investigated. Phase plane, bifurcation plots and Lyapunov exponents are presented to verify the chaotic behavior. Second, nonlinear active plus proportional integral sliding mode control (NA-PISMC) is proposed to control microscopic chaos in the chemical reactor system. A proportional integral switching surface is proposed to achieve the stability condition of the error dynamics and controller is designed by using the relevant variables of the chemical system. Unlike the open loop and open plus closed loop control techniques, the design of proposed controller does not require the parameter perturbation. The required stability condition is derived based on Lyapunov stability theory. Simulation is done in MATLAB environment. Numerical simulation results are presented in order to show the effective performances of the proposed controller design. Simulation results correspond that the objectives of chaos existence and chaos control are achieved successfully.