The objective of this paper is to retain the desirable dynamics performances and improve ride quality for active suspensions with the actuator faults and unknown road disturbances. To that end, a novel proportional-integral observer (PIO)-based fault-tolerant tracking controller (FTTC) design is proposed for automobile active suspensions (ASSs) encountered with actuator faults and parameter uncertainties. First, the Takagi-Sugeno (T-S) fuzzy model approach is adopted to establish T-S representation of the faulty ASSs by describing vehicle dynamics system as the weighed summation of a common linear system. Afterwards, a nominal robust H∞ output feedback controller is developed to enhance the suspension performances under fault-free mode, whose output response indicators are taken as the prescribed reference trajectories. Then, a PIO-based fault estimator is designed to predict both the system states and the unmeasurable actuator faults, synchronously. On basis of this designed observer, the expected PIO-FTTC is synthesized to track the prescribed reference trajectories, and further to make up for the system performance deteriorations aroused by the actuator faults. Finally, a simulative investigation demonstrates the effectiveness and feasibility of the proposed PIO-FTTC compared to existing control approach.