We appreciate the comments by Drs. Cotton, Solomons, Dubois, and Coburn, but would like to express the following points: 1. The original paper by Solomons et al.1 speculated that arginine was effective because of its ability to buffer gastric acid, enhance ". . mixed micelle formation, . . . break hydrogen bonds, bind metal ions, and act as a detergent." It was with these properties in mind and also with the observation by Solomons et al. that five of their seven patients studied without pancreatic enzyme supplement seemed to have a significant reduction in steatorrhea when treated with arginine, that we decided to study the effect of the compound alone-without exogenous enzyme.