Properties Of Hydroxypropyl Methylcellulose Films Research Articles

Enhanced mechanical and antimicrobial properties of hydroxypropyl methylcellulose films incorporating silver nanoparticles for wound dressing applications

Enhanced mechanical and antimicrobial properties of hydroxypropyl methylcellulose films incorporating silver nanoparticles for wound dressing applications

Effect of bovine bone collagen and nano-TiO2 on the properties of hydroxypropyl methylcellulose films

Hydroxypropyl methylcellulose (HPMC) film containing bovine bone collagen (BC) and nano-TiO2 were developed via casting method. The films were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), and their mechanical properties, barrier properties, thermal stability and surface color were investigated. The results showed that polymer matrices of HPMC and BC had good compatibility. The nano-TiO2 could be well embedded and dispersed in the matrix of HPMC/BC films, resulting in homogeneous, continuous and compact structure of the composite films. The addition of BC and nano-TiO2 significantly (p < .05) changed the surface color parameters of the films (p < .05). In addition, the introduction of BC and nano-TiO2 had a positive effect on the improvement of mechanical properties, barrier properties and thermal stability of the HPMC based films. The results suggest that HPMC based films containing BC and nano-TiO2 are more suitable for active packaging in the food industry.

Physical and morphological properties of hydroxypropyl methylcellulose films with curcumin polymorphs

Native curcumin (UC, untreated curcumin) was treated (TC, treated curcumin) using antisolvent precipitation technique and incorporated in hydroxypropyl methylcellulose (HPMC) based film solution. Curcumin particles and films were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. In addition, thickness, moisture content, color, barrier permeability (water, O2 and CO2), mechanical and thermal properties of films as well as the release of curcumin from film to food simulant was investigated. The results obtained by several techniques showed that TC polymorphs were obtained by antisolvent precipitation with lower particle size than native curcumin. HPMC films showed a partially crystalline structure and homogeneous distribution of ingredients analyzed by XRD and SEM, respectively. Thickness, moisture content, mechanical properties and water vapor permeability of HPMC films were not altered with the presence of UC or TC. A higher percentage of curcumin release (53.9%) was obtained for HPMC-TC films when compared with HPMC-UC films (curcumin release of 7.9%). Results suggest that HPMC films containing TC by antisolvent precipitation could be used as active packaging in the food industry.

On the effects of hydroxyl substitution degree and molecular weight on mechanical and water barrier properties of hydroxypropyl methylcellulose films

In line with the increasing demand for sustainable packaging materials, this contribution aimed to investigate the film-forming properties of hydroxypropyl methylcellulose (HPMC) to correlate its chemical structure with film properties. The roles played by substitution degree (SD) and molecular weight (Mw) on the mechanical and water barrier properties of HPMC films were elucidated. Rheological, thermal, and structural experiments supported such correlations. SD was shown to markedly affect film affinity and barrier to moisture, glass transition, resistance, and extensibility, as hydroxyl substitution lessens the occurrence of polar groups. Mw affected mostly the rheological and mechanical properties of HPMC-based materials. Methocel® E4 M led to films featuring the greatest tensile strength (ca., 67 MPa), stiffness (ca., 1.8 GPa), and extensibility (ca., 17%) and the lowest permeability to water vapor (ca., 0.9 g mm kPa−1 h−1 m−2). These properties, which arise from its longer and less polar chains, are desirable for food packaging materials.

Jute cellulose nano-fibrils/hydroxypropylmethylcellulose nanocomposite: A novel material with potential for application in packaging and transdermal drug delivery system

Nowadays, bio-derived cellulose nano-fibrils based nanocomposites is gaining utmost interest in the area of barrier films for food packaging, as reinforcing filler to make biodegradable nanocomposites with different biopolymers for various applications such as transdermal drug delivery, edible packaging and tissue scaffolding. Ultrasound-assisted preparation of hydroxypropylmethylcellulose based nanocomposites with cellulose nano-fibrils were carried out following solution mixing technique. The crystalline nature of cellulose nano-fibrils has been scrutinized by X-ray diffraction study. The field emission-scanning electron micrographs of cellulose nano-fibrils revealed a network of nano-fibrillar morphology. The Fourier transform infrared spectroscopy results of cellulose nano-fibrils confirmed the removal of lignin and hemicellulose from raw jute (Corchorus olitorius L.) fibres. The storage modulus and tensile properties of hydroxypropyl methylcellulose films increased up to the addition of 1.00 wt% cellulose nano-fibrils. The moisture affinity of hydrophilic hydroxypropylmethylcellulose has also been reduced at 1.00 wt% cellulose nano-fibrils loading. The impact of cellulose nano-fibrils loading on the cumulative percentage of drug release from prepared nanocomposites films has been explored accordingly. By utilizing these versatilities of cellulose nano-fibrils, the fabricated nanocomposites are expected to be highly promising in the area of packaging and transdermal drug delivery system.

Effect of clay concentration on morphology and properties of hydroxypropylmethylcellulose films

Hydroxypropylmethylcellulose (HPMC)/montmorillonite (MMT) nanocomposite films are prepared by solution intercalation method. Mechanical, thermal, moisture absorption, optical clarity and water vapor permeability of HPMC/MMT nanocomposite films are measured. X-ray diffraction (XRD) and transmission electron microscopic (TEM) results establish formation of partially intercalated and partially exfoliated HPMC/MMT nanocomposite films. In presence of MMT, the tensile strength, tensile modulus and elongation at break of HPMC films are improved. The thermal stability of HPMC/MMT nanocomposites is better than pure HPMC. The moisture absorption of HPMC film measured in 75% of constant relative humidity is reduced with loading of MMT. Optical clarity of HPMC film is almost unaffected in presence of MMT. Water vapor permeability of HPMC decreases in presence of nanoclay due to increasing tortuous path for diffusion.

Miniaturization of cellulose fibers and effect of addition on the mechanical and barrier properties of hydroxypropyl methylcellulose films

Cellulose fibers were miniaturized by microfluidics technology to decrease their size and incorporated in hydroxypropyl methylcellulose (HPMC) films to study the effect of addition of such fibers on the mechanical and barrier properties of HPMC films suitable for application in food packaging. The particle size of fibers and the mechanical properties, water vapor and oxygen permeabilities, total pore volume, and light and electron microscopy micrographs of films were analyzed. Incorporation of cellulose fibers in the films improved their mechanical and barrier properties significantly. This study is the first to investigate the use of microfluidics technology for the purpose of decreasing the size of cellulose fibers and the addition of reduced size microfibers to improve physical properties of HPMC films.

Cellulose derivative based active coatings: Effects of nisin and plasticizer on physico-chemical and antimicrobial properties of hydroxypropyl methylcellulose films

Bioactive composite coatings based on hydroxypropyl methylcellulose (HPMC), broad-spectrum food preservative nisin (Nisaplin®), and hydrophilic plasticizer glycerol were evaluated for mechanical, barrier (O2, H2O), transparency and microbiological effectiveness. Incorporation of Nisaplin® into cellulose derivative, i.e. HPMC-based films strongly increased the film thickness due to salt crystallization while glycerol had normalized it by homogenous dispersibility. The tensile strength of composite films decreased, however ultimate elongation was increased significantly. The dynamic vapour sorption experimental data fitted by different models had shown lesser values of respective energy constants for composite films. The transparency and water permeability of HPMC films were negatively affected by the additives as an effect individual but conversely as combined effect for film transparency. Film bioactivity demonstrated efficacy against Listeria > Enterococcus > Staphylococcus > Bacillus spp. These cellulose derivative based active films may thus be a key approach towards eradicating post-process contamination of healthy foods.

Effect of surfactants on water sorption and barrier properties of hydroxypropyl methylcellulose films

Moisture sorption isotherms and water barrier properties of films made from hydroxypropyl methylcellulose (HPMC) containing surfactant mixtures of sorbitan monostearate (SPAN 60) and sucrose palmitate (sucrose ester P-1570) were evaluated at 10 °C. The effect of hydrocolloid/surfactant ratio ( H/ S) (0.5, 1.0 and 1.5) and the hydrophilic/lipophilic balance of the mixture (HLB: 4.7, 6.0 and 8.0) was analysed. GAB and BET sorption models were tested to fit the experimental data. The equilibrium moisture content of films increased dramatically above a w=0.6. Films with greater H/ S ratio have greater water binding capacity. For a specific hydrocolloid/surfactant ratio, equilibrium moisture content of the coatings decreased as the HLB of the surfactant mixture increased. Equilibrium moisture contents of the composite films could be predicted from the corresponding values of pure compounds and the respective component mass fractions by a linear model, in the water activity range of 0.11–0.75. At the high relative humidity at which water permeability of the films was evaluated, the water vapour barrier was effective when the films reached a critical amount of surfactants ( H/ S=0.5).

The mechanical properties of pigmented tablet coating formulations and their resistance to cracking II. Dynamic mechanical measurement

The stress relaxation properties of hydroxypropyl methylcellulose films containing iron oxides, titanium dioxide, lakes, or talcs as pigments were measured. Talc was shown to enhance the ability of the films to relax and this was related to the lower incidence of cracking of tablet film coatings containing talc compared with those pigmented by other materials.