Proper Safety Research Articles

Improving Safety in High-Altitude Work: Semantic Segmentation of Safety Harnesses with CEMFormer

The symmetry between production efficiency and safety is a crucial aspect of industrial operations. To enhance the identification of proper safety harness use by workers at height, this study introduces a machine vision approach as a substitute for manual supervision. By focusing on the safety rope that connects the worker to an anchor point, we propose a semantic segmentation mask annotation principle to evaluate proper harness use. We introduce CEMFormer, a novel semantic segmentation model utilizing ConvNeXt as the backbone, which surpasses the traditional ResNet in accuracy. Efficient Multi-Scale Attention (EMA) is incorporated to optimize channel weights and integrate spatial information. Mask2Former serves as the segmentation head, enhanced by Poly Loss for classification and Log-Cosh Dice Loss for mask loss, thereby improving training efficiency. Experimental results indicate that CEMFormer achieves a mean accuracy of 92.31%, surpassing the baseline and five state-of-the-art models. Ablation studies underscore the contribution of each component to the model’s accuracy, demonstrating the effectiveness of the proposed approach in ensuring worker safety.

Occupational exposure assessment of heavy metals in human scalp hair among tannery workers in Bahir Dar, Ethiopia: Indication of pollution

Ethiopia, is one of the African countries, has immense potential for skins and hides for the leather industries, which will play a crucial role in converting nations into manufacturing-driven economies through industrialization. The chemicals applied in the tanning process are a serious concern for employees and the community if proper safety measures are not taken. The pollution status of employees working in Anbessa and Bahir Dar tannery factories was evaluated by collecting hair samples. After the hair samples washed with acetone, and deionized water, the hair samples were digested with 4 mL of HNO3 and 2 mL of HClO4 for 1:30 h at 250 °C. The levels of metals (Cr, Pb, Zn, Cu, Ni, and Cd) were subsequently analyzed using a Flame Atomic Absorption Spectrophotometer (FAAS). The mean concentrations of Cu, Ni, Zn, Pb, and Cr in the Anbessa tannery factory workers were 17.34–22.75, 16.38–35.03, 235.4–369.2, 30.46–67.31, and 97.56–189.18, respectively, in the various working departments of the factory. Similarly, the concentrations of Cu, Ni, Zn, Cd, Pb, and Cr in the hair of Bahir Dar tannery workers were 30.1–105.9, 17.88–62.20, 216.9–762.1, 0.35–5.21, 33.42–91.42, and 118.5–305.7, respectively. Chromium was found to be the most accumulated metal next to Zn with in both tannery workers that highlighted significant occupational health risks. The principal component analysis (PCA) analysis provide an insights into the interactions between occupational factors and metal exposure. In conclusion, the results of hair analysis from the employees of tannery factories indicates alarming levels of metal exposure, especially for zinc and chromium, which might pose health problems in long time exposure. Thus, it's critical to monitor occupational activities that can harm human health and the environment.

Assessing oncology nurses’ knowledge and practices in safe cytotoxic drug handling and waste management in a Moroccan tertiary centre

ABSTRACT Because of the rising burden of cancer worldwide, cytotoxic drugs have become a significant threat to health and the environment. This investigation assessed the level of knowledge of oncology nurses regarding the risks associated with handling cytotoxic drugs and the management of cytotoxic waste and their impact on health and the environment. A qualitative study was conducted among oncology nurses at a Moroccan oncology centre. Most demonstrated a good understanding of cytotoxic drugs and their handling. But, there were notable deficiencies in foundational training. Occasional training sessions were offered, but they were considered insufficient in frequency and depth. The workload was identified as a major obstacle to proper safety protocol implementation. Although all participants recognised the dangers of improper disposal of cytotoxic waste, none had detailed knowledge of the specific environmental impacts. Improved training programmes and a reduced workload are critical to enhancing safety and efficiency in oncology centres.

From knowledge to action: Assessing the effectiveness of immersive virtual reality training on safety behaviors in confined spaces using the Kirkpatrick model

Safety in the industrial sector is paramount, with national legislations establishing specific regulations to reduce accidents. These regulations emphasize risk removal and proper operator training as preventive measures. However, traditional training can be time-consuming and costly, leading companies to meet only the minimum requirements. In particular, confined spaces pose significant dangers, often resulting in fatal, cascading accidents due to a lack of proper safety procedures. Therefore, effective training is crucial to mitigate these risks.Advanced technologies like Immersive Virtual Reality (IVR) present new opportunities for cost-effective and extensive training campaigns by eliminating the risks associated with real environment training, offering a safe yet realistic experience.Despite the widespread adoption of IVR training applications in industrial research, there is a notable lack of systematic approaches to evaluate their effectiveness. Conducting such evaluations is crucial to ascertain their impact on essential training outcomes, including participant engagement, knowledge transfer, and enhanced safety behavior during work activities.To address this gap, we developed an IVR-based training platform for confined space safety procedures and established a systematic validation procedure using the Kirkpatrick model to assess its effectiveness compared to conventional training methods. Results demonstrate that IVR training provides an excellent user experience, better knowledge transfer than the traditional approach, and improved performance in simulated procedures, reducing execution errors and completion times. This dual focus on creating and validating the IVR system underscores its potential as an effective training tool in hazardous environments such as confined spaces, where proper training can prevent tragic fatalities.

Validity and reliability of chemical-based disinfectant use questionnaire in a sample of the Lebanese public community

IntroductionWorldwide, people heavily use chemical-based disinfectants to prevent the spread of COVID-19 with limited or no safety instructions. Awareness about the safe use of chemical-based disinfectants is highly recommended to...

Treatment of juvenile myasthenia gravis with tacrolimus: A cohort study.

We investigated the proper timing, efficacy and safety of tacrolimus for juvenile myasthenia gravis (JMG). We conducted a retrospective cohort study for JMG patients treated with tacrolimus at Xiangya Hospital, Central South University, Changsha, China from 2010 to 2023. The clinical information of patients with a follow-up of more than 1 year was collected. Comparisons of clinical features between groups of patients who achieved therapeutic goal and those who did not achieve therapeutic goal as well as between groups of patients treated with tacrolimus within or after 1 year from JMG onset was carried out. Forty-three patients were enrolled, of whom 28 achieved therapeutic goal. Tacrolimus reduced glucocorticoids (GC) dosages for the 28 cases and 15 cases discontinued GC completely. Generalized myasthenia gravis (GMG) subtype had an association with a group of patients who achieved therapeutic goal (p = 0.001). Median duration from JMG onset to tacrolimus use was 10.50 months for those who achieved therapeutic goal and 36.00 months for those who did not achieve therapeutic goal (p = 0.010). The median Myasthenia Gravis Activities of Daily Living (MG-ADL) score improved significantly (p = 0.003). The initiation of tacrolimus within 1 year of JMG onset showed an association with achievement of therapeutic goal (p = 0.026). GMG subtype showed an association with a group of patients who received tacrolimus within 1 year (p = <0.001). Tacrolimus side effects were tolerable. The provision of tacrolimus within 1 year of JMG onset is effective and safe.

Smart Wearable Device for Enhancing Safety and Efficiency of Coal Miners

The task of ensuring worker safety in underground coal mines has never been simple. It has always been challenging to ensure worker safety in underground coal mines. Coal miners are seriously injured or killed as a result of numerous fatal and non-fatal accidents all over the world. Accidents occur as a result of lack of monitoring of mining areas and failure to implement proper safety measures. In this review, the coal miner's smart wearable safety device is implemented. A smart wearable safety device that will monitor the miner's health and provides precautionary measures for the miner's safety has been developed with the advent of the Industrial Internet of Things (IIoT). Integrating smart wearable safety devices with various health sensors such as a pulse rate sensor, temperature sensor, blood oxygen sensor, gas sensor, and camera, and then connecting it to Node MCU, and the internet enhances the safety of coal miners. Sensors constantly transmit sensor data to the cloud, and if an unusual situation arises, it notifies the responsible person in the control room as well as the miners. Since deep underground mining is especially susceptible to toxic gases, low levels of oxygen, and hazardous gases, the MQ gas sensor family can detect them. The proposed system is primarily used to improve working conditions inside coal mines and to ensure workers' safety.

Navigating Green Ship Recycling: A Systematic Review and Implications for Circularity and Sustainable Development

The shipping industry is the cornerstone that facilitates the movement of approximately 90% of international commercial goods. However, environmental challenges, particularly in the ship recycling (SR) industry, have become increasingly evident. Via closed-loop production patterns within an economic system, a circular economy aims to improve resource-use efficiency by focusing on urban and industrial waste to achieve better balance and harmony between the economy, environment, and society. A key element in this process is a well-executed disassembly that enables reuse, remanufacturing, high-value recycling, and implementing other circular strategies. Based on a systematic literature review, this paper delineates the SR process, identifies influential scholarly works on recycling end-of-life ships, discusses factors affecting shipowners’ decision to recycle, and opportunities for sustainability and circularity in SR processes. The results confirm the increasing need for green SR to reduce shipbreaking waste. Also discussed is how greening SR could be integrated into sustainable development goals under proper environmental and safety regulations and an aligned cultural mindset for stakeholders.

DESIGNING OF COMPUTER VISION BASED SAFETY GEAR DETECTION USING YOLO V8 AND JETSON NANO

Abstract—Enhancing worker safety on construction sites is pivotal, as lapses in wearing safety gear such as helmets, masks, and vests can lead to potential hazards. To address this issue, we introduce a novel solution leveraging the YOLO V8 device to detect helmet usage among workers. However, challenges arise due to security unawareness and discomfort, causing helmet removal. To mitigate this risk, we propose an advanced system employing the Jetson Nano board and . This system not only detects helmet adherence but also monitors the use of safety masks and vests. Unlike the existing YOLO V5-based approach, our proposed system adopts YOLO V8, ensuring heightened accuracy. The integration of a CSI Camera Module further enhances real-time monitoring capabilities. Through the synergy of Jetson Nano, YOLO V8 and CSI Camera Module, we pioneer an innovative solution to enforce safety compliance by preventing unauthorized entry without proper safety measures. Index Terms— NVIDIA Jetson Nano, Object detection, Deep Learning, YOLO V8, CSI Camera module.

Occupational Hazards in Lead-acid Battery Factories in Bangladesh: Assessing Excess Heat, Noise, Chemical Exposures, and Health Impacts on Workers

BackgroundLead-acid battery (LAB) manufacturing is growing in Bangladesh because of the expanding automotive industry and low lead prices. Although these factories employ a big workforce, the working environment has led to concerns about the possible health risks for employees. This study aimed to address this issue by investigating workplace chemical and physical hazards in three LAB industries and evaluating health outcomes among workers. MethodsA cross-sectional study was conducted among 72 LAB factory workers, and participants were recruited by simple random sampling. A validated questionnaire was used to collect information on self-reported exposures to physical and chemical risks and related health effects. Data analysis was performed by using statistical software SPSS version 25. ResultsThe age and work experience (Mean ± SD) of the participants were 34.2 ± 7.7 and 10.0 ± 5.7 years, respectively. High workplace temperature and noise from machinery, chemical odors, and skin exposure to acid (H2SO4) were reported by 52.8%, 51.4%, and 20.8% of workers, respectively. Insomnia (25.0%), abdominal pain (18.1%), joint pain (38.9%), memory loss (19.4%), headache (15.3%), low back pain (47.2%), eyesight problem (19.4%), physical weakness (47.2%), and hypertension (19.4%) were all common symptoms among the workers. ConclusionOur study findings indicate that workers in LAB factories in Bangladesh are exposed to extreme temperatures, hazardous materials, and uncomfortable levels of noise, which can lead to serious health risks. To ensure the safety and well-being of employees, the LAB manufacturing sector in Bangladesh requires the immediate implementation of proper occupational health and safety standards.

COVID-19 Modified mRNA “Vaccines”: Lessons Learned from Clinical Trials, Mass Vaccination, and the Bio-Pharmaceutical Complex, Part 1

Our understanding of COVID-19 synthetic, modified mRNA (modmRNA) products and their public health impact has evolved substantially since December 2020. Published reports from the original randomized placebo-controlled trials concluded that the modmRNA injections could greatly reduce COVID-19 symptoms. However, the premature termination of both trials obviated any reliable assessment of potential adverse events due to an insufficient timeframe for proper safety evaluation. Following authorization of the modmRNA products for global distribution, problems with the methods and execution of the trials have emerged. The usual safety testing protocols and toxicology requirements were bypassed. Many key trial findings were either misreported or omitted entirely from published trial reports. By implication, the secondary estimates of excess morbidity and mortality in both trials must be deemed underestimates. Rigorous re-analyses of trial data and post-marketing surveillance studies indicate a substantial degree of modmRNA-related harms than was initially reported. Confidential Pfizer documents had revealed 1.6 million adverse events by August 2022. A third were serious injuries to cardiovascular, neurological, thrombotic, immunological, and reproductive systems, along with an alarming increase in cancers. Moreover, well-designed studies have shown that repeated modmRNA injections cause immune dysfunction, thereby potentially contributing to heightened susceptibility to SARS-CoV-2 infections and increased risks of COVID-19. This paper also discusses the insidious influence of the Bio-Pharmaceutical Complex, a closely coordinated collaboration between public health organizations, pharmaceutical companies, and regulatory agencies. We recommend a global moratorium on the modmRNA products until proper safety and toxicological studies are conducted.

Defect Detection in Synthetic Fibre Ropes using Detectron2 Framework

Fibre ropes with the latest technology have emerged as an appealing alternative to steel ropes for offshore industries due to their lightweight and high tensile strength. At the same time, frequent inspection of these ropes is essential to ensure the proper functioning and safety of the entire system. The development of deep learning (DL) models in condition monitoring (CM) applications offers a simpler and more effective approach for defect detection in synthetic fibre ropes (SFRs). The present paper investigates the performance of Detectron2, a state-of-the-art library for defect detection andinstance segmentation. Detectron2 with Mask R-CNN architecture is used for segmenting defects in SFRs. Mask R-CNN with various backbone configurations has been trained and tested on an experimentally obtained dataset comprising 1,803 high-dimensional images containing seven damage classes (placking high, placking medium, placking low, compression, core out, chafing, and normal respectively) for SFRs. By leveraging the capabilities of Detectron2, this study aims to develop an automated and efficient method for detecting defects in SFRs, enhancing the inspection process, and ensuring the safety of the fibre ropes.

Moisture Safety in Prefabricated Roof Renovations: Causes and Strategies

Achieving carbon neutrality by 2050 requires extensive energy renovation of the existing building stock. In this study we focus on deep renovation with prefabricated insulation elements as a potential solution to attain the required renovation speed and volume. The use of such elements without a proper moisture safety strategy can, however, lead to moisture-related problems, including mould growth. Here we examine the causes of moisture and mould damage in a case study of a building that has been renovated to near-zero energy standards using prefabricated insulation elements. The study elucidates the reasons for the moisture damages detected and proposes two moisture safety strategies to improve the situation. The first strategy emphasizes the importance of ensuring dry construction conditions by either using a full temporary roof or avoiding rainfall during installation. The second strategy addresses localized water damage to the attic floor and involves the use of protective measures, active ventilation and a correct installation sequence. In the case of local moisture damage, the required amount of ventilation air flow during summer is 0.5–0.55 l/(s·m²). During cooler periods, heating is needed. The employed methods include modelling the case-study building with the IDA Indoor Climate and Energy software, as well as mould growth risk assessment based on temperature and relative humidity measurements. The results highlight the effectiveness of both strategies in preventing mould growth if applied correctly, and emphasize the need for thorough planning, moisture safety regulations and rapid response to ensure successful renovation with prefabricated insulation units. The study provides valuable information on moisture safety strategies for serial renovations with prefabricated elements. The existence and proper implementation of a moisture safety strategy is important for achieving the desired energy performance goals while maintaining building durability and occupant health, and it needs to be applied throughout the chain of site management: from the main contractor down to the skilled worker.

Comprehensive analysis of occupational radiation exposure and radiation safety practices in cardiac catheterization laboratories: A five-year experience

AimThe objective is to analyze the occupational radiation dose experienced by medical workers in the Cardiac catheterization Lab in Bahrain and evaluate their adherence to established radiation safety protocols. Material and methodsRetrospective analysis for the Hp(10) and Hp(0.07) doses over a five-year (2017–2021). Descriptive analyses conducted for both annual dose and cumulative data across all years for all healthcare workers. A questionnaire was administered to evaluate their adherence to radiation safety protocols. Descriptive statistics were conducted for all responses and ANOVA was conducted to discern differences in best practices across various demographics groups. ResultsNo single dose exceeded the dose limits and 89.4% of the workers received Hp(10) and Hp(0.07) radiation doses of less than 2 mSv. The overall mean and range of the annual Hp(10) and Hp(0.07) radiation dose over the 5-year study period for all workers were 1.07 (9.50-0.01) and 0.64 (11.30-0.02), respectively. The overall mean and range of the annual Hp(10) and Hp(0.07) (mSv) for cardiologists were 1.79 (9.50-0.04) and 1.42 (11.30-0.07), respectively. The survey showed inconsistent practices and gaps. In best practice scoring, physicians had highest score and cardiovascular technologists scored the lowest. ConclusionIt is important to emphasize proper radiation safety practices for healthcare professionals to reduce the risk of long-term repeated exposure. Commitment to radiation safety is shows the dedication to providing high-quality care and adhering to radiation safety practices is an ethical obligation towards patient. There is a need for tailored training on radiation safety and enforcement of safety measures.

Consumer-Focused Meat Science Extension Program Increase Consumer Confidence and Knowledge of Meat Selection and Preparation

Science-based, meat science education is often limited outside of universities, creating possibilities to develop Extension activities to educate and impower consumers in principles of meat science. The Indiana BBQ Bootcamp was developed to provide consumers information on meat selection, proper cooking techniques, food safety, and meat seasoning (spice rubs and marinades) through demonstrations and product sampling. Attendees were surveyed before and after the program to report their confidence in their ability to perform basic meat science techniques. Responses to all survey questions showed significant increase in the attendees’ confidence demonstrating improvement in their meat science knowledge.

Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE.

In the phase 2 PACIFIC-STROKE trial (Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following Acute Noncardioembolic Stroke), asundexian, an oral factor XIa inhibitor, did not increase the risk of hemorrhagic transformation (HT). In this secondary analysis, we aimed to investigate the frequency, types, and risk factors of HT on brain magnetic resonance imaging (MRI). This was a secondary analysis of the PACIFIC-STROKE trial. Patients with mild-to-moderate acute noncardioembolic ischemic stroke were randomly assigned to asundexian or placebo plus guideline-based antiplatelet therapy. Brain MRIs were required at baseline (≤120 hours after stroke onset) and at 26 weeks or end-of-study. HT was defined using the Heidelberg classification and classified as early HT (identified on baseline MRI) or late HT (new HT by 26 weeks) based on iron-sensitive sequences. Multivariable logistic regression models were used to test factors that are associated with early HT and late HT, respectively. Of 1745 patients with adequate baseline brain MRI (mean age, 67 years; mean National Institutes of Health Stroke Scale score, 2.8), early HT at baseline was detected in 497 (28.4%). Most were hemorrhagic infarctions (hemorrhagic infarction type 1: 15.2%; HI2: 12.7%) while a few were parenchymal hematomas (parenchymal hematoma type 1: 0.4%; parenchymal hematoma type 2: 0.2%). Early HT was more frequent with longer symptom onset-to-MRI interval. Male sex, diabetes, higher National Institutes of Health Stroke Scale large (>15 mm) infarct size, cortical involvement by infarct, higher number of acute infarcts, presence of chronic brain infarct, cerebral microbleed, and chronic cortical superficial siderosis were independently associated with early HT in the multivariable logistic regression model. Of 1507 with follow-up MRI, HT was seen in 642 (42.6%) overall, including 361 patients (23.9%) with late HT (new HT: 306; increased grade of baseline HT: 55). Higher National Institutes of Health Stroke Scale, large infarct size, cortical involvement of infarct, and higher number of acute infarcts predicted late HT. About 28% of patients with noncardioembolic stroke had early HT, and 24% had late HT detectable by MRI. Given the high frequency of HT on MRI, more research is needed on how it influences treatment decisions and outcomes.

A review on potential adverse effects associated with Janus-kinase inhibitors

Rheumatoid arthritis (RA) is a chronic, symmetrical, inflammatory autoimmune disease that affects small joints. RA has a population prevalence of 0.5% to 1% in the U.S. The annual cost of care for chronic treatment of RA in the United States is estimated at $12,509. Pharmaceutical companies have developed drugs to treat RA using Janus kinase (JAK) inhibitors. These drugs can have potential adverse effects. Forecasting a better output to JAK inhibitors (JAKI’s). Therapy duration of JAKI’s and Problems regarding to strategies of dose reduction or if the discontinuation of therapy takes place in case of low disease activity. The accurate pharmacological profile and interactions of other drugs with JAKI’s have to establish. Proper safety, efficacy profile of JAKI’s and when administered in combination with DMARD’s. The safety, efficacy data of JAKI’s when compared to non-anti-TNF biologics. Obtaining of experience on JAKI’s that were already existed in the market and further experimental findings on newer compounds and which may clarify many of the aspects which are to be solved in nearer future as these JAKI will have greater application in treatment of RA. Regardless of significant developments in latest years in the pharmacotherapy of RA in the use of JAK inhibitors, yet the adverse effects of JAK inhibitors are unanswered. Therefore, one of the main concerns associated with JAK inhibitor is the potential adverse effects. The challenges can be addressed by clinical pharmacist mediated interventions related to dosing of JAK inhibitors and proper management of adverse drug reactions (ADRs).

Archery injuries: A literature review

BACKGROUND: Archery is one of the oldest human skills that survived to the present day. At first, it was used for hunting and war and later became a sport. The interest in archery has grown annually. Each type of sport has specific injuries. Information about archery-related injuries will allow us to develop preventive measures and help make this sport safer. The article will be useful for coaches, sports doctors, physiotherapists, and orthopedic surgeons.&#x0D; AIM: To present modern information about frequency, types of archery-related injuries, and preventive methods.&#x0D; MATERIALS AND METHODS: The publication search was performed in the PubMed/MEDLINE databases from 1978 to 2023 using combinations of OR, AND operators, and keywords: archery, archery injuries, rotator cuff injuries, arrow injuries, and overuse. Consequently, we extracted 49 foreign and domestic scientific sources.&#x0D; RESULTS: Archery injuries occur in 4.4 per 10,000 people involved in this sport. Acute injuries in archers are rare, mainly due to shooting errors and most often lead to soft tissue damage because of a fracture of a bow, arrow, or bowstring during a shot (83.3%) or as a result of touching the bowstring with a bow. Chronic injuries occur in 83.9% of archery athletes. The main risk factors for their occurrence include overuse, high repetitions during training, lack of strength of the athlete, and incorrect technique. Overuse (67.9%) is the most common cause of chronic tendon, ligament, and joint injuries. Injuries occurred in 30%–53% of cases in the shoulders (rotator cuff tear, scapular dyskinesia, and shoulder impingement syndrome), 12.8% in the elbow (medial and lateral epicondylitis and traumatic bursitis), 8.9%–19.9% in the spine and forearm (chronic tendovaginitis and tunnel syndromes).&#x0D; CONCLUSIONS: Proper training and safety measures help prevent acute injuries. Practicing archery techniques and strength training are the main measures of preventing muscle overuse and reducing the incidence of chronic injuries.

Factor XI inhibition in patients with acute coronary syndrome.

A hypercoagulable condition is typical of patients with acute coronary syndrome and is a determining factor in the genesis of recurrent ischaemic events. Modern pharmacological therapies consisting of antiplatelets and anticoagulants derive their rationale for use on the pathophysiological mechanisms most commonly associated with myocardial infarction (MI); they have contributed to reducing the ischaemic risk of these patients, but left ample room for improvement. In particular, trials that have studied the association of an anticoagulant with antiplatelet drugs have provided promising results in terms of efficacy, but highlighted a significant bleeding risk. Evidence derived from experimental animal and epidemiological studies has shown how factor XI (FXI) deficiency is associated with a reduction in thrombotic events but with modest bleeding. These data added to the role that FXI plays in the coagulation cascade constituted an incipit for the pharmacological attempt to decouple thrombosis from haemostasis by means of the inhibition of this factor. The theoretical assumption that FXI inhibitor drugs may be able to reduce the ischaemic risk without significantly increasing the haemorrhagic risk makes these compounds a potential therapeutic aid for patients in secondary prevention after acute MI. To date, on these patients, we only have data from a Phase 2 trial, PACIFIC-AMI (Study to Gather Information About the Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2 433 334 in Patients Following an Acute Heart Attack). In this study, the primary endpoint-represented by the Bleeding Academic Research Consortium (BARC) composite of Type 2, 3, or 5 bleeding-showed no significant differences between the various doses of asundexian tested (10, 20, and 50 mg quoque die), and between these and placebo (asundexian all doses vs. placebo: hazard ratio, 0.98; 90% confidence interval, 0.71-1.35). The data on efficacy, however, showed neutral results, but it should be noted that the study did not have the adequate statistical power to evaluate this outcome. Valuable information could, therefore, derive in the future from the ongoing Phase 3 trial with milvexian, LIBREXIA-ACS (A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome) and from any future studies that could be started by testing different molecules.

The relationship between homelessness and psychiatric disorders in an inpatient sample

IntroductionThere are more than ten thousand homeless people in Hungary. Earlier studies confirmed the connection between mental health issues and homelessness. Furthermore, homeless care places a significant burden on the healthcare system, with psychiatric departments being no exception.Objectivesto compare demographic and treatment characteristis of homeless and not homeless inpatients in the psychiatric department of Jahn Ferenc South Pest Hospital (JFSPH), and thus providing a different perspective compared to previous studies, shedding light on the relationships from a different angle.MethodsIn our retrospective study, we analyzed all inpatients’ data treated in the psychiatric department of JFSPH over a 4-month period (03/2023-07/2023). Patients were divided into two groups: those with housing and those who were homeless. We compared the two groups based on the following variables: gender, age, length of inpatient treatment, diagnosis, psychiatric history, employment status; smoking, alcohol and drug use; valid health insurance, invalidity pension and guardianship status; and long-acting injectable antipsychotic treatment.ResultsThe percentage of homeless individuals treated in the psychiatric department of JFSPH was 18%. There was a significant difference in the length of inpatient stay between the two groups, homeless patients spent more than 100% longer time under inpatient treatment. Regarding psychiatric history, there was no significant difference between the two patient groups. When examining the employment status of the sample, we found significantly more unemployed patients im the homeless group. Comparing to the control group, there were significantly more alcohol consumers, smokers, and substance users among the homeless. Long-acting antipsychotic injections were administered significantly more frequently to homeless patients. A significantly higher percentage of homeless individuals were declared invalidated, and a significantly higher proportion of them were placed under guardianship compared to the group with housing. Homeless individuals were significantly more likely to have no social insurance compared to the control group.ConclusionsIn summary, we can conclude that significant difference have been found between the homeless and not homeless groups in most of the examined variables. These results implicates that the inpatient care of homeless patients poses significant bourden on the inpatient system. Early prevention and effective rehabilitation of substance use disorders could decrease this burden. Establishing a proper social safety network and enhancing community psychiatric care could potentially also relieve the burden of inpatient care system.Disclosure of InterestNone Declared