Proper Integration Research Articles

Interactions between the fovea and the periphery shape misbinding of visual features in a continuous report paradigm

AbstractHuman object perception depends on the proper integration of multiple visual features, such as color and motion. When features are integrated incorrectly, they are perceptually misbound and can cause illusions. This study investigates the phenomenon of continuous misbinding of color and motion features in peripheral vision, addressing the role of spatial continuity and color configuration in binding processes. Using a novel continuous report task, human subjects reported the perceived movement direction of color-coded dots in the peripheral visual field that were either congruent or incongruent with a foveal stimulus. Results indicate that spatial continuity is crucial for feature misbinding, with a marked decrease in peripheral perceptions bound to match foveal perception when the foveal and peripheral stimuli are spatially disjointed. Additionally, performance improved significantly when peripheral and foveal features were aligned, suggesting a ‘positive illusion’ effect where congruent features enhance perceptual accuracy. This effect was independent of the color pairings used, challenging the notion that color processing discrepancies might drive erroneous perception in this stimulus. These findings highlight the complex interplay between spatial configuration and perceptual accuracy in visual feature integration, with implications for understanding the neural basis of vision and developing applications to address perceptual inaccuracies in visual disorders.

Abstract 4124828: The Methylation Landscape Of Human Aortic And Mitral Valvular Interstitial Cells

Valvular interstitial cells (VICs), the valves’ predominant cell type, are crucial in ensuring proper valve function, structural integrity, tissue repair and valve homeostasis. DNA methylation regulates gene expression profiles and a matched aortic to mitral human VIC methylation analysis will further our understanding of aortic- and mitral-specific VIC biology and pathobiology. This is the first study analyzing methylation profiles of non-diseased, matched human aortic and mitral VICs. We analyzed the differential methylation fingerprint of 12 non-diseased aortic and mitral VICs (10 males:2 females; 42–64 years) extracted from de-endothelialized leaflets using reduced representation bisulfite sequencing (RRBS) on HiSeq2500. Analysis of methylation levels of 12,676 genome-wide promoters revealed 651 differentially methylated (DM) promoters. The top 3 DM promoters were linked to TBX4 (meth diff = -28.9%, P = 5.2E-135) essential for valve morphogenesis, to EXOC3L2 (meth diff = 25.7%, P = 1.3E-92) and NT5DC2 (meth diff = -20.3%, P = 7.1E-69) potentially implicated in ECM remodeling, the former via vesicle trafficking and the latter through nucleotide metabolism. Functional classification and network analysis showed that the genes associated with the DM promoters were enriched for WNT-, TGFβ-, FGF-, EGF- and PDGF- pathways involved in physiological processes such as valve development, repair and VIC regulation, as well as pathological processes such as calcification. Additional enrichment was detected for integrin- and cadherin- pathways involved in cell-cell-ECM interactions and endothelin- and VEGF pathways involved in hemodynamic regulation. This work provides the first insight into the differential methylation regulation patterns of human aortic and mitral VICs. Understanding how aortic and mitral VICs are differentially epigenetically regulated will extend our understanding of their role in aortic- and mitral-specific leaflet homeostasis, susceptibility to disease processes and will contribute to dynamic innovative experimental setup designs, animal-free human-based modeling frameworks, tissue engineering and drug identification approaches.

High-Performance Concrete from Rubber and Shell Waste Materials: Experimental and Computational Analysis

Waste and its environmental impact have driven the search for sustainable solutions across various industries, including construction. This study explores the incorporation of solid waste in the production of eco-friendly structural concrete, aiming to reduce pollution and promote ecological and sustainable construction practices. In this context, two types of eco-friendly concrete were produced using marine shells and recycled rubber as waste materials and compared with conventional concrete through experimental and computational approaches. The results demonstrated that the concrete with marine shells achieved a compressive strength of 32.4 MPa, 26.5% higher than conventional concrete, and a 1% reduction in weight. In contrast, the recycled rubber concrete exhibited a compressive strength of 22.5 MPa, with a 2 MPa decrease compared to conventional concrete, but a 4.3% reduction in density. Computational analysis revealed that porosity affects Young’s modulus, directly resulting in a reduction in the maximum achievable strength. This work demonstrates that it is feasible to produce eco-friendly structural concrete through the proper integration of industrial waste, contributing to decarbonization and waste valorization.

Integration of AI in Education and Didactic Childhood Advancement and Progress

The state of education in our country has been a contentious topic for many years. Numerous reforms have been done but there are still some problems – inefficient learning resources, is but one of the many. Due to inexperience on this topic this problem continues to plague the education system. However, taking an informed and educated approach with the interests of the students prioritized, we believe that many of these problems could be solved with the use of Artificial Intelligence (AI). Its proper integration into the education system could aid in the improvement of efficiency of learning resources, through the use of various tools like chatbots, adaptive learning systems and intelligent assessment systems. By implementing the use of AI in a world where learning resources are scarce, there can be standardized learning throughout the country regardless of availability of learning materials. The main agenda of this study is to explore ways of implementing the use of Artificial Intelligence into educational systems to integrate the use of learning materials, hence bringing about improved quality of education. We are fully aware of the problems facing the implementations of this study but we are ready to conduct rigorous research to combat them.

Arabidopsis RALF4 Rapidly Halts Pollen Tube Growth by Increasing ROS and Decreasing Calcium Cytoplasmic Tip Levels

In recent years, the rapid alkalinization factor (RALF) family of cysteine-rich peptides has been reported to be crucial for several plant signaling mechanisms, including cell growth, plant immunity and fertilization. RALF4 and RALF19 (RALF4/19) pollen peptides redundantly regulate the pollen tube integrity and growth through binding to their receptors ANXUR1/2 (ANX1/2) and Buddha’s Paper Seal 1 and 2 (BUPS1/2), members of the Catharanthus roseus RLK1-like (CrRLK1L) family, and, thus, are essential for plant fertilization. However, the signaling mechanisms at the cellular level that follow these binding events remain unclear. In this study, we show that the addition of synthetic peptide RALF4 rapidly halts pollen tube growth along with the excessive deposition of plasma membrane and cell wall material at the tip. The ratiometric imaging of genetically encoded ROS and Ca2+ sensors-expressing pollen tubes shows that RALF4 treatment modulates the cytoplasmic levels of reactive oxygen species (ROS) and calcium (Ca2+) in opposite ways at the tip. Thus, we propose that pollen RALF4/19 peptides bind ANX1/2 and BUPS1/2 to regulate ROS and calcium homeostasis to ensure proper cell wall integrity and control of pollen tube growth.

When the Study of the Post-Synthetic Modification Method on a 1D Spin Crossover Coordination Polymer Highlights its Catalytic Activity.

We are interested in studying the catalytic activity of the spin crossover (SCO) complex ([Fe(NH2trz)3](NO3)2). In this work, we demonstrate that, by adapting the experimental conditions, we can switch from a quantitative post-synthetic modification (PSM) reaction to the use of this complex as a catalyst for the formation of imine from 4-amino-1,2,4-triazole. During the catalytic reaction, the iron complex undergoes two different PSM reactions: the first is the action of the aldehyde on the NH2 groups present on the complex, whereas the second PSM reaction occurs between the imine complex and aminotriazole, leading back to the starting complex. These two PSM reactions are at least partially involved in the catalytic mechanism. Furthermore, the combination of these two PSM reactions enables us to modulate the particle size and shape of the final amine complex without altering its excellent SCO properties. This result is of interest in the field of heterogeneous catalysis, where particle size has a strong influence on the catalytic activity, and for the proper integration in devices for different applications.

Barriers and enablers towards integrated care for sexual violence victims in humanitarian settings

Abstract Background Sexual violence (SV) is a complex public health issue that necessitates a coordinated multisectoral response. Ideally, this response should be provided through an integrated care package to strengthen timely access and comprehensive care for victims. However, in humanitarian settings with high levels of SV, care is often offered through fragmented silos, exacerbating the burden on the health workforce and victims. Methods Using the Valentijn framework, a qualitative, real-time Delphi study was conducted with 17 SV care experts representing 7 geographical subregions to gain informed opinions on key contextual and health system barriers and enablers for integrated care for SV victims in humanitarian settings. Results Challenges and enablers reported across the diversity of the participants’ contexts showed consistency. Contextual challenges included volatile contexts, collapsed health systems, and poor infrastructure. Professional challenges included a lack of expertise among healthcare providers (HCPs), high staff attrition, and compassion fatigue among HCPs. Health systems challenges included poor referral and coordination mechanisms, insufficient resources, misaligned donor-programme priorities and low prioritisation of SV comprehensive care. Key enablers reported were effective networking, community engagement, capacity building, co-locating services, participatory management, promoting staff’s sense of ownership, digitalised information systems, and joint patient files. Conclusions The sustainability of integrated care for SV victims can be strengthened by ensuring HCPs access regular psychological support and training and are incentivised to provide quality care. Regular coordination among actors, including donors, can support integrating care that responds to patients’ holistic needs. Further research is needed to assess HCPs’ and SV victims’ experiences of current service delivery and how to optimise integrated care in humanitarian settings. Key messages • Addressing care providers challenges in humanitarian settings, such as high attrition, lack of training, psychosocial support, and burnout, can ensure proper integration of sexual violence care. • Integration of sexual violence care demands systemic changes, including aligning donor-programme goals, building accountability mechanisms and the buy-in of political and community leaders.

Multisystemic Therapy for a Child in Difficult Circumstances With Disruptive Behavior in China: A Single-Case Design

Purpose: This study aims to address concerns about the ability of Chinese social workers to collaborate with multiple systems and effectively implement multisystemic therapy (MST), given their low professional status. Based on the first MST practice in Mainland China, the study evaluates the effectiveness of MST in addressing disruptive behaviors in a child in difficult circumstances (CDCs), assesses its fitness within the Chinese context, and explores strategies for social workers to collaborate within the contexts of the specialized protection system for CDCs and the establishment of social work service stations. Method: A single-case AB research design with repeated measures across multiple contexts was adopted. Results: The study suggests MST's potential effectiveness and cultural and political compatibility in China, and identifies three strategies for social workers to intervene across multiple systems. Conclusion: MST could be a valuable tool in social work practice with proper integration into local systems in China.

Enhancing Conceptual Understanding of Electricity and Magnetism through VR Simulations

The study explores the efficacy of Virtual Reality (VR) simulations in enhancing students’ conceptual understanding of electricity and magnetism, using the Labster platform. Traditional teaching methods often need to adequately convey the complexities of these topics, leading to limited student engagement and poor comprehension. The research compares two groups: one receiving traditional instruction and another using VR-based simulations. The study found that students in the experimental group, who used VR simulations, showed a 35% improvement in post-test scores, compared to a 15% improvement in the control group. The VR group also reported higher levels of engagement and found abstract concepts such as electric fields and circuits easier to understand through interactive, immersive learning environments. Teachers noted that VR aided in visualizing difficult concepts, although challenges included a learning curve in technology usage and the need for proper integration into curriculum. The findings suggest that VR, when used as a supplemental tool, has the potential to significantly improve learning outcomes in physics education. However, the study highlights the need for further research into long-term impacts and accessibility issues and strategies to better integrate VR into traditional teaching methods.

The Current State of Lymphedema Surgery

Lymphedema surgeries have been proven effective in treating lymphedema and are not considered experimental or unproven. The medical literature consistently supports the safe and successful use of physiologic drainage lymphedema surgeries such as lymphaticovenous anastomosis (LVA), vascularized lymph node transfer (VLNT), and reductive surgeries such as suction-assisted protein lipectomy (SAPL) when performed by an experienced lymphedema surgery team to treat properly selected patients. Proper integration of lymphedema therapy is critical to achieving successful outcomes. We review effective lymphedema surgeries, their indications, patient selection, and the proper application of surgical treatments to achieve optimal results.

Navigating the complex policy landscape for carbon farming in The Netherlands and the EU

Background The EU carbon removal and carbon farming (CRCF) framework sets the quality requirements for voluntary greenhouse gas certification schemes for i) permanent removal, ii) temporary carbon storage in long-lasting products, iii) temporary carbon storage from carbon farming, and iv) soil emission reduction. The next step is to develop “tailored certification methodologies for different types of carbon removal activities.” Via CRCF compliant certification schemes, certificates can be issued and sold to generate extra funding for carbon farming via voluntary carbon markets or other (future) performance-based incentive schemes (e.g., Agri sector Emissions Trading Scheme). Method We provide a qualitative assessment of the complex landscape of carbon farming incentive schemes and their associated monitoring, reporting, verification, and certification (MRV-C) frameworks. To illustrate these complexities, we take the farmers’ perspective of a Dutch dairy farmer that wants to implement different carbon farming activities (i.e., a portfolio), while aiming to secure a decent farm-level income. We discuss the farmers’ challenge by analyzing different options and routes for the financial valorization for several carbon farming activities. Results We find that the incremental MRV-C and incentive schemes, like the EU CRCF and potential agri-ETS are likely to add to the existing administrative burden for (carbon) farmers in the EU. Proper alignment, integration and standardization of the EU CRCF with existing MRV-C infrastructure(s) is needed to limit the administrative burden and transaction costs. Also, there is a need to provide better ex-ante clarity to (carbon) farmers and investors on the complementarity of incentive schemes from different policy domains (e.g., agriculture, climate, energy, bioeconomy). Conclusion We argue that the complexity of the MRV-C and incentives landscape ads to the administrative burden and flag this a potential source of inertia for investments in carbon farming. We conclude with recommendations to simplify and streamline the policy mix and MRV-C processes.

University Teachers’ Views on the Adoption and Integration of Generative AI Tools for Student Assessment in Higher Education

This study examines the factors that may impact the adoption of generative artificial intelligence (Gen AI) tools for students’ assessment in tertiary education from the perspective of early-adopter instructors in the Middle East. It utilized a self-administered online survey and the Unified Theory of Acceptance and Use of Technology (UTAUT) model to collect data from 358 faculty members from different countries in the Middle East. The Smart PLS software 4 was used to analyze the data. The findings of this study revealed that educators developed new strategies to integrate Gen AI into assessment and used a systematic approach to develop assignments. Moreover, the study demonstrated the importance of developing institutional policies for the integration of Gen AI in education, as a driver factor influencing the use of Gen AI in assessments. Additionally, the research identified significant factors, namely performance expectancy, effort expectancy, social influences, and hedonic motivation, shaping educators’ behavioral intentions and actual use of Gen AI tools to assess students’ performance. The findings reveal both the potential advantages of Gen AI, namely enhanced student engagement and reduced instructor workloads, and challenges, including concerns over academic integrity and the possible negative impact on students’ writing and thinking skills. This study emphasizes the significance of targeted professional development and ethical criteria for the proper integration of Gen AI in educational assessment.

Opportunities for the integration of muslim immigrants in European Union countries

The presence of Muslim immigrants in European Union countries has become an undeniable reality, as these immigrants have become an integral part of the demographic composition of EU societies. The strength of these immigrant communities has increased as a result of the intensification of family reunification policies, which have contributed to reshaping and expanding minorities within the European space. Consequently, questions, concerns, and doubts have arisen about the integration of these immigrants into most national communities. These apprehensions are primarily based on the legal mechanisms required to integrate these minorities into the nation-state, which is founded on citizenship rights in Europe, and on the practical measures that guarantee their integration in an appropriate form and content. On this basis, the adopted integration policies that attempt to reposition Muslims in Europe at the economic, social, and, to some extent, cultural levels raise many concerns about their ability to integrate these Muslim immigrants and about the possible opportunities for their proper integration in light of their cultural, religious, and social specificities. Through this paper, researchers attempt to examine the opportunities for these Muslim immigrants to integrate, considering the legal complexities and social problems they face, which hinder their complete integration into these societies.

Perspectives of stakeholders on onboard training: A thematic analysis of qualitative interviews

ABSTRACT The training and education of seafarers have evolved significantly with the establishment of the International Maritime Organization (IMO) and the adoption of International Convention on Standards of Training, Certification and Watchkeeping for Seafarers (STCW). This paper explores maritime industry key stakeholders’ perspectives on onboard training (OBT) focusing on its benefits, curriculum, and challenges. The thematic analysis of the opinions of representatives of key stakeholders highlighted the critical role of OBT in providing real-world experience, applying theoretical knowledge in practice, and gaining cultural insights essential for maritime cadets’ professional growth. Some obstacles related to financial constraints of shipping companies, common ship activities, living conditions on board, unexpected weather conditions, regulatory inconsistencies, and characteristics of curriculum, such as trainers’ competencies, number of trainers on board, different implementation of OBT by different companies were revealed. The respondents agreed that the traditional 12-month OBT period is necessary, however proper integration of technological advancements in achieving competences with harmonized international regulations, updated curriculum, and enhanced stakeholder collaboration can be helpful to reduce the duration of OBT. Further research should identify competences to be developed through integration of technologies including simulator training.

IGZO TFT Backplane Integration for µLED Flat-Panel Display

The focus of this work is the process integration of Indium Gallium Zinc Oxide (IGZO) transistors as a µLED backplane for row/column addressing. A single pixel is composed of a µLED driven by an arrangement of two transistors and a storage capacitor. The pixels are then arrayed on a glass substrate to support active-matrix control of monochrome and full color (RGB) displays from 1x1cm (50 x 50 pixels) up to 7.6 x 7.6 cm (380 x 380 pixels). Optimization of circuit parameters considering size and scan frequency was modeled using existing TFT and µLED electrical device compact models. New process parameters and procedures were determined for the proper integration of µLEDs in an existing TFT fabrication process. Red, green, and blue µLED devices were fabricated at Tyndall National Institute on native substrates and were transferred to TFT pixels using an X-Display MTP-1003 micro-transfer printer. The performance of individual test cells was assessed using an Agilent B1500, revealing a voltage transfer characteristic indicating the ability to modulate and control µLED current.

Using Virtual Reality in the Educational Process to Increase Students' Motivation and Interest

This article aims to identify some obstacles and opportunities for using virtual reality tools in teaching English to students. The research method is a case study focusing on the perceptions and responses of four teachers. Semi-structured interviews were used to collect this data. The results show the importance of pre-service and in-service training for teachers to use a foreign language effectively - in this case, English - when teaching with these tools. Additionally, teachers highlight specific difficulties that hinder the realisation of the educational opportunities offered by virtual reality in the process of foreign language learning. The results show that, for example, despite the overall level of satisfaction, motivation is not always present in the use of smartphones. In contrast, satisfaction, motivation, and engagement are closely related in virtual reality. These differences emphasise the importance of technology in the learning process. The novelty of this paper is to study these discourses to find that the main motivations that drive teachers to use new virtual tools are related to both personal factors (curiosity, passion, interest) and pedagogical aspects (application, sharing experiences with colleagues, caring for students). These two forms of motivation, essential for proper technology integration, underline the strong desire of teachers to participate in the project to improve their teaching practice and optimise student learning. However, although motivation is an influential factor in integrating new technologies, teachers do not hide their doubts and concerns. The practical value of the study on using virtual reality (VR) in the educational process to increase students' motivation and interest is creating an interactive environment that can engage students and make learning more fun. This is especially important for those with difficulties with traditional teaching methods and individualising learning. VR allows you to adapt the material to the needs of each student, which contributes to more effective learning. Learners can work at their own pace and repeat the material as often as necessary.

The Impact of Climate Change on Global Economic Stability: Developing Economic Policies to Manage Climate Risks

The paper explores the impact of climate change on global economic stability while also placing consideration on the role of economic policy towards the management of climate change risk. Climate change represents one of the pressing environmental challenges of the 21st century with profound repercussion on the economic stability while also affecting several sectors such as agriculture, energy, tourism and health. The increased rate of change in the climatic condition has led to a wide spread of severe weather conditions such as hurricanes, flooding, drought, tsunamis, wild fire etc. This has necessitated the need for a robust economic policy that would aid in the mitigation effort against the release of greenhouse gases into the atmosphere, as well as providing adaptation against the harmful impact of climate change. The role of the agreement of 2015 Paris frame work was examined as it provides an important foundation for global cooperation in the fight against climate change. It is expected that proper integration of financial institution and the private sector would provide the necessary funding and technical support that would aid in the implementation of green technology as well as promote sustainable development.

Role of the Immune System and Stem Cells in Dental Conservation

Background: Dental conservation aims to maintain teeth's appearance and functionality through various procedures. Recent advancements in stem cell research and immune system roles in tooth tissue regeneration highlight their crucial roles in oral health. The immune system is essential for healing after dental treatments and helps maintain oral health. A robust immune response can expedite the healing of damaged oral tissues and prevent further infections, enhancing the outcomes of dental conservation therapies. Purpose: This literature review examines immune system modulation and stem cell therapy in dental conservation, highlighting their potential benefits and challenges in tissue regeneration and treatment outcomes. Methodology: This review analyzes literature on the immune system and stem cell roles in dental tissue regeneration, assessing the effectiveness of immunomodulatory substances and their synergy in healing processes and tissue integration. Result: The review highlights that immunomodulatory substances effectively reduce inflammation and support regeneration, improving dental conservation outcomes. Stem cells, particularly mesenchymal stem cells from dental pulp, show promising results in clinical applications such as pulp regeneration and alveolar bone repair. The combination of immune system modulation and stem cell therapy offers superior outcomes compared to traditional methods, enhancing the quality of tissue regeneration and accelerating healing. However, challenges such as preventing adverse immune responses and ensuring proper integration of transplanted cells with host tissue remain. Ongoing research and technological advancements are expected to enhance dental conservation techniques' effectiveness and efficiency.

Analysis of the Use of Energy Storage in the Form of Concrete Slabs as a Method for Sustainable Energy Management in a System with Active Thermal Insulation and Solar Collectors

One effective approach to reducing the energy required for heating buildings is the use of active thermal insulation (ATI). This method involves delivering low-temperature heat to the exterior walls through a network of pipes carrying water. For ATI to be cost-effective, the energy supply must be affordable and is typically derived from geothermal or solar sources. Solar energy, in particular, requires thermal energy storage (TES) to manage the gap between summer and the heating season. A building that integrates various renewable energy systems and heating/cooling technologies should be managed efficiently and sustainably. The proper integration of these systems with smart management strategies can significantly lower a building’s carbon footprint and operational costs. This study analyzes the use of concrete slabs as a method for sustainable energy management in a system incorporating active thermal insulation and solar collectors. Using ambient temperature and solar radiation data specific to Cracow, Poland, the simulations evaluate the feasibility of employing a concrete slab positioned beneath the building as a thermal storage tank. The results reveal some drawbacks of using concrete slabs, including high temperatures that negatively affect system efficiency. Increased temperatures lead to higher heat losses, and during summer, inadequate insulation can cause additional heat leakage into the building. The findings suggest that water may be a more effective alternative for thermal energy storage.

Toward Ensuring Data Quality in Multi-Site Cancer Imaging Repositories

Cancer remains a major global health challenge, affecting diverse populations across various demographics. Integrating Artificial Intelligence (AI) into clinical settings to enhance disease outcome prediction presents notable challenges. This study addresses the limitations of AI-driven cancer care due to low-quality datasets by proposing a comprehensive three-step methodology to ensure high data quality in large-scale cancer-imaging repositories. Our methodology encompasses (i) developing a Data Quality Conceptual Model with specific metrics for assessment, (ii) creating a detailed data-collection protocol and a rule set to ensure data homogeneity and proper integration of multi-source data, and (iii) implementing a Data Integration Quality Check Tool (DIQCT) to verify adherence to quality requirements and suggest corrective actions. These steps are designed to mitigate biases, enhance data integrity, and ensure that integrated data meets high-quality standards. We applied this methodology within the INCISIVE project, an EU-funded initiative aimed at a pan-European cancer-imaging repository. The use-case demonstrated the effectiveness of our approach in defining quality rules and assessing compliance, resulting in improved data integration and higher data quality. The proposed methodology can assist the deployment of big data centralized or distributed repositories with data from diverse data sources, thus facilitating the development of AI tools.