Proper Coordination Research Articles

The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division.

Bacterial cell division requires the coordinated assembly and disassembly of a large protein complex called the divisome; however, the exact role of molecular chaperones in this critical process remains unclear. We here provide genetic evidence that ClpX unfoldase activity is a determinant for proper coordination of bacterial cell division by showing the growth defect of a Staphylococcus aureus clpX mutant is rescued by a spontaneously acquired G325V substitution in the ATP-binding domain of the essential FtsA cell division protein. The polymerization state of FtsA is thought to control initiation of bacterial septum synthesis and, while restoring the aberrant FtsA dynamics in clpX cells, the FtsAG325V variant displayed reduced ability to interact with itself and other cell division proteins. In wild-type cells, the ftsAG325V allele shared phenotypes with Escherichia coli superfission ftsA mutants and accelerated the cell cycle, increased the risk of daughter cell lysis, and conferred sensitivity to heat and antibiotics inhibiting cell wall synthesis. Strikingly, lethality was mitigated by spontaneous mutations that inactivate ClpX. Taken together, our results suggest that ClpX promotes septum synthesis by antagonizing FtsA interactions and illuminates the critical role of a protein unfoldase in coordinating bacterial cell division.

Optimizing Goods Claims Processing Time in Logistics Operations Through Website-Based Applications with the DMAIC Approach

PT XYZ is an e-commerce company which offers an electronic buying and selling platform for a wide variety of products from many sellers to buyers. As an industry engaged in the commercial sector, logistics has a vital role in shipping goods from upstream to downstream to meet consumer desires. However, conditions in the field are not always in accordance with the plans. Lost or damaged goods during delivery or at the Warehouse are a frequent problem. PT XYZ, through its XYZ Logistics team, implements a claims system for replacing items lost or damaged during the operational process. Currently, the claim submission system is done manually via email. This manual claim system creates many problems due to the lack of proper coordination between stakeholders. Therefore, this study proposed a solution with a lean six sigma approach using the DMAIC (Define, Measure, Analyze, Improve and Control) method. The solution offered to improve PT XYZ's claim system is to design an automated claim system using a website-based application. After implementing a website-based application to automate the XYZ logistics claim process, it was proved that the company was able to reduce lead time by up to 60% from initial conditions, up to 33% of stakeholder workload, and improve data security and real-time supervision.

Dependency on bamboo by local communities in various agro climatic zones of Madhya Pradesh in India

A study has been carried out in 12 Forest Divisions of 11 agro climatic zones from Madhya Pradesh (India) in which 1374 Basod household were surveyed. The present work revealed that maximum income contribution of Basod families from traditional business were found in districts of Malwa Plateau agro climatic zone (65.12%) followed by, Satpura Plateau (58.8%), Vindhya Plateau (50.71%), Central Narmada Valley (47.25%), Chhattisgarh Plains (46.48%), Northern hills regions of Chhattisgarh (45.49%), Nimad Plains (41.53%), Jhabua hills (41.59%), Kaimur Plateau & Satpura hills (41.25%) whereas minimum contribution of Basod family annual income was found in Bundelkhand (38.79%) agro climatic zone. During the study it was observed that maximum number of consumption of bamboo for traditional business was found in districts of Bundelkhand zone (Average number of bamboo culms per annum is 421.6) whereas minimum number of consumption was observed in Satpura plateau (Average number of bamboo culms per annum is 171.6). Minimum average requirement of bamboo was found in Central Narmada Valley (657.6 culms per annum). This study revealed, cultivation of bamboo can be a profitable economy across the agro-climatic zones of Madhaya Pradesh, if proper coordination is maintained between farmers and traders.

Project performance and the effects of human activity: a case study of the University of Salford

Conflict is common in the project management industry. Project performance may be impacted negatively or favourably by human activities such as competing interests among stakeholders, project team members, and project managers, as well as by the intimidating methodology and structure of the project management process. This case study at the University of Salford looked into how human activity affects project management and performance. The mixed methodology used in this study allowed for a deeper understanding of the real-world experiences of the subjects and project teams. Project management students and professionals from the University of Salford provided the data, which was collected. The survey generated a sample size of 40 responses, of which 37 were reliable enough for analysis. At the University of Salford, it was discovered that relationships among team members were a crucial human activity that promoted cooperation, trust, and the extension of trust to others, thereby reducing conflict and ties of trust between stakeholders and project managers. However, positive team dynamics and strong group cohesion are required to actively and purposefully encourage conflict in order to achieve the project's aim, goals, and deliverables. Conflict in project performance and project management productivity, for example, may be reversed. Therefore, to achieve high performance and productivity, the project management process needs strong communication, positive team dynamics, and an understanding of scope. Conflict can have a negative effect on the process, lowering productivity and performance. Project managers should develop their communication skills to avoid this because it is a soft skill that can be learned and enhanced. This guarantees proper coordination, awareness of all stakeholders, and a decrease in conflict.

Modulating Coordination of Iron Atom Clusters on N,P,S Triply-Doped Hollow Carbon Support towards Enhanced Electrocatalytic Oxygen Reduction.

Constructing atom-clusters (ACs) with in situ modulation of coordination environment and simultaneously hollowing carbon support are critical yet challenging for improving electrocatalytic efficiency of atomically dispersed catalysts (ADCs). Herein, a general diffusion-controlled strategy based on spatial confining and Kirkendall effect is proposed to construct metallic ACs in N,P,S triply-doped hollow carbon matrix (MACs /NPS-HC, M=Mn, Fe, Co, Ni, Cu). Thereinto, FeACs /NPS-HC with the best catalytic activity for oxygen reduction reaction (ORR) is thoroughly investigated. Unlike the benchmark sample of symmetrical N-surrounded iron single-atoms in N-doped carbon (FeSAs /N-C), FeACs /NPS-HC comprises bi-/tri-atomic Fe centers with engineered S/N coordination. Theoretical calculation reveals that proper Fe gathering and coordination modulation could mildly delocalize the electron distribution and optimize the free energy pathways of ORR. In addition, the triple doping and hollow structure of carbon matrix could further regulate the local environment and allow sufficient exposure of active sites, resulting in more enhanced ORR kinetics on FeACs /NPS-HC. The zinc-air battery assembled with FeACs /NPS-HC as cathodic catalyst exhibits all-round superiority to Pt/C and most Fe-based ADCs. This work provides an exemplary method for establishing atomic-cluster catalysts with engineered S-dominated coordination and hollowed carbon matrix, which paves a new avenue for the fabrication and optimization of advanced ADCs.

Modulating Coordination of Iron Atom Clusters on N,P,S Triply‐Doped Hollow Carbon Support towards Enhanced Electrocatalytic Oxygen Reduction

AbstractConstructing atom‐clusters (ACs) with in situ modulation of coordination environment and simultaneously hollowing carbon support are critical yet challenging for improving electrocatalytic efficiency of atomically dispersed catalysts (ADCs). Herein, a general diffusion‐controlled strategy based on spatial confining and Kirkendall effect is proposed to construct metallic ACs in N,P,S triply‐doped hollow carbon matrix (MACs/NPS−HC, M=Mn, Fe, Co, Ni, Cu). Thereinto, FeACs/NPS−HC with the best catalytic activity for oxygen reduction reaction (ORR) is thoroughly investigated. Unlike the benchmark sample of symmetrical N‐surrounded iron single‐atoms in N‐doped carbon (FeSAs/N−C), FeACs/NPS−HC comprises bi‐/tri‐atomic Fe centers with engineered S/N coordination. Theoretical calculation reveals that proper Fe gathering and coordination modulation could mildly delocalize the electron distribution and optimize the free energy pathways of ORR. In addition, the triple doping and hollow structure of carbon matrix could further regulate the local environment and allow sufficient exposure of active sites, resulting in more enhanced ORR kinetics on FeACs/NPS−HC. The zinc‐air battery assembled with FeACs/NPS−HC as cathodic catalyst exhibits all‐round superiority to Pt/C and most Fe‐based ADCs. This work provides an exemplary method for establishing atomic‐cluster catalysts with engineered S‐dominated coordination and hollowed carbon matrix, which paves a new avenue for the fabrication and optimization of advanced ADCs.

ПОДАТКИ І КОНТРОЛЬ У СФЕРІ ЛІСОВОГО ГОСПОДАРСТВА

The article examines the problematic issues of interrelationship and interaction of state control in the field of forestry in terms of the completeness of the management of taxes and fees to the budget by economic entities. The role and tasks of the state policy of ensuring control over revenues to the state budget by business entities in the forestry sector are shown. The dialectical relationship between budget revenues and expenditures in the context of damage and losses caused to the forest fund, in particular, from the war, is analyzed and substantiated. Some areas of improvement of the legislation for the effective use and restoration of forest resources, as well as timely receipt of rent for forest use to the state and local budgets, are substantiated. The analysis of the effectiveness of the performance of powers by state authorities made it possible to identify several trends and testified to the need for proper interaction and coordination of actions of state authorities in order to ensure effective mechanisms for increasing control in the process of forming and paying taxes to the budget.

Mechatronic Pole System for Monitoring the Correctness of Nordic Walking.

Marching with Nordic walking (NW) poles is a common form of physical activity. It is recommended in the treatment and rehabilitation of many diseases. NW's wide range of applications in rehabilitation and its effectiveness are limited by the need for experienced physiotherapists to supervise patients during the training. A prerequisite for good rehabilitation results is correctly using the poles during walking. Essential parameters of NW include the angle of inclination of the pole, the force of the pole on the ground, and proper coordination of performed movements. The purpose of this paper is to present the design and operating principle of a mechatronic NW pole system for measuring and recording the gait parameters. The subject of the work was the assessment of the usefulness of the mechatronic NW pole system for phases identified during marching. The study was conducted in field conditions. The study's main objective was to compare the obtained results from the developed system with those of a commercial system for measuring foot pressure distributions on the ground. The paper also presents sample results measuring walkers' gait with NW poles in the field and the resulting gait phase analysis.

MODERNIZATION OF THE RUNER OF A HIGH-HEAD HYDRAULIC TURBINE TO THE SPECIFIED PARAMETERS

The paper considers the problem of modernizing the runner of a high-head Francis turbine for the specified parameters. The modernized runner must meet modern requirements for efficiency and cavitation. Using a package of application programs, a blade system of the runner was developed for the accepted parameters of the optimal mode with high energy-cavitation performance. The results of the computational analysis of flow parameters in the flow space of the high-head hydro turbine Fr310 of increased speed are presented. Constantly growing requirements for improving the energy qualities of hydraulic turbines necessitate the improvement of methods that allow predicting and optimizing the energy characteristics of the flow space. Improving the energy-cavitation performance of hydraulic turbines poses the task of further developing the method of mathematical modeling of the workflow. The use of a numerical experiment based on a mathematical model of the workflow is an effective means of finding rational options for both newly designed and modified elements of the flow space of hydraulic turbines. A necessary component of the design of the flow part is the selection of a number of geometric parameters of the runner (meridional outlines of the cavity, input and output edges of the blade, etc.), the correctness of which significantly affects the energy performance. When choosing the geometric parameters of an runner, one is usually guided by experimental data obtained for hydraulic turbines depending on the speed. This approach does not ensure proper coordination of the geometric parameters of the runner, which often results in both a discrepancy between the design mode and the optimal one and an insufficiently high level of energy performance.

Optimal charging of plug-in electric vehicles and renewable energy sources integration considering PV/WT/BT based on cost and emission reduction

The integration of Electric Vehicles (EVs) on the power system with Renewable Energy Sources (RESs) can have both positive and negative impacts. The positive impact could provide a comfort on the generation system and the EV, on the other hand, the negative impact increases the Greenhouse Gas (GHG) along with the cost and emission. Proper management and coordination will be needed to ensure that the integration is optimized for maximum benefit. The purpose of this article is to investigate the EV integration impact from the perspective of cost and reliability. The integration of EVs can also impact renewable energy generation. For example, if EVs are charged during periods of high renewable energy generation, it could lead to curtailment of RESs if the electricity demand from EVs is not balanced with the supply of renewable energy.

Displaced Women and Sexual and Reproductive Health Services: Exploring Challenges Women With Sexual and Reproductive Health Face in Displaced Camps of Nigeria

Background: Displaced women are affected by sexual and reproductive health (SRH) challenges, often exacerbated by poor living conditions, limited access to healthcare, and cultural norms. The aim of this study was to explore SRH issues, the effects of displacement into camps on women’s SRH, and challenges with accessing and utilizing SRH services among women in camps for the displaced in Benue State, Nigeria. Methods: A qualitative phenomenological approach was employed to gain an in-depth understanding of the women’s SRH challenges, based on 12 focus group discussions between women of different age groups and eight in-depth interviews. The data were collected using tape recorders and notes. Data analysis followed a thematic approach. Ethical approval and appropriate consent were obtained for the study. Results: The majority of research participants stated that sexually transmitted disease/human immunodeficiency virus was the most serious SRH issue in the camp. Their stay in camp enhanced the women’s vulnerability and exposed them to sex in exchange for basic needs/palliatives, increasing their SRH challenges. Access to and use of SRH services were impacted by their migratory lifestyle, cultural and religious views, lack of SRH knowledge, and other difficulties. Short-term approaches to intervention, health providers’ poor communication, and attitudes were reported to affect SRH service use. Conclusion: There is an urgent need for comprehensive interventions to address SRH challenges among women in displaced settings, including proper coordination of humanitarian services, education on transactional sex, encouragement of men to participate in SRH initiatives, and expansion of access to services, as well as the training and hiring of culturally competent healthcare providers.

Managing Spiritual Growth: The Crucial Role Of Educational Management In Christian Religious Education

This study explores the crucial role of educational management in Christian Religious Education (CRE) and emphasizes its significance in shaping the curriculum and objectives of CRE programs. It delves into the integral relationship between educational management and CRE, highlighting the need for systematic adherence to educational management principles within religious education. Effective educational management ensures the clear communication and achievement of goals and objectives in CRE. By organizing the curriculum, setting standards, and implementing teaching strategies, educational management fosters an environment conducive to the spiritual growth and development of students. Moreover, educational management provides guidance for educators in delivering CRE effectively. Through proper planning, coordination, and evaluation, educational management aligns the teaching-learning process with the overall objectives of education. It also facilitates resource allocation to support the implementation of CRE, ensuring that educators receive necessary training and support. The study concludes that integrating sound management principles into CRE is essential for creating meaningful learning experiences that nurture students' spiritual growth. It emphasizes the importance of recognizing the impact of educational management on the quality and effectiveness of CRE programs. Overall, the study underscores the imperative for educators and stakeholders in religious education to embrace best practices in educational management. By doing so, they can create an environment where students thrive both spiritually and academically, contributing positively to their communities and the world at large.

Cryptocurrency and central bank digital currency: an insight from the regulatory perspective

The scope of direct transactions globally with almost zero transaction cost and keeping transactions anonymous without facing any centralized control has caused a huge demand for cryptocurrency worldwide whereas its excess volatility, no underlying backings, no centralized control, and anonymity behind transactions have contributed significant risk for the entire financial system. Unlike cryptocurrency, Central Bank Digital Currency, being a virtual currency backed by the central bank or the monetary authority of a country serves all the functions of money, such as a store of value, a unit of account, and a medium of exchange, facilitates the attainment of macroeconomic goals and financial stability. To ensure the safeguarding of the interest of the people, business enterprises, and the financial system of a country from a broader perspective, adequate regulatory measures regarding cryptocurrency are a must. There should be proper harmonization and coordination among the countries regarding the regulatory approach as the markets of cryptocurrency are integrated globally.

THE EFFICACY OF CLIMATE CHANGE FINANCING ON SUSTAINABLE ECONOMIC DEVELOPMENT IN NIGERIA

Climate change has become an increasingly pressing issue across the world, particularly in developing countries, and Nigeria is no exception. As climate change continues to create severe weather cycles such as floods and droughts, Nigeria has looked for ways to tackle the resulting development challenges. One option that has arisen is the utilization of climate change financing to drive economic development. This paper seeks to evaluate the efficacy of climate change financing on sustainable economic development in Nigeria. A comprehensive literature review of relevant studies was conducted to assess the efficacy of climate change financing on sustainable economic development in Nigeria. The research showed that climate change financing has many potential benefits, such as reducing poverty and inequality, promoting economic growth, and creating employment opportunities. Climate change financing also has the potential to provide communities with the resources needed to adapt to the changing climate and improve their resilience. However, the research also revealed that the efficacy of climate change financing depends on proper management, governance, and coordination. The paper further discusses policy recommendations for the effective utilization of climate change financing for sustainable economic development in Nigeria. It emphasizes the need for a greater focus on improving the management, governance, and coordination of climate change financing projects. The paper concludes by proposing further areas of research that could be explored in order to better understand the efficacy of climate change financing on sustainable economic development in Nigeria.

Ancillary Services and Risk Assessment of Networked Microgrids Using Digital Twin

The networked microgrids (NMGs) have become one of the better means of improving the resiliency and reliability of power system networks. NMGs need proper coordination of all microgrids in either grid-tied or isolated mode. This study proposes the use of a digital twin (DT) for the energy management of NMGs in the distribution system. The NMGs are virtually represented using a neural network (NN) by training the data from the different optimal results of unit commitment (UC). The UC formulation of NMGs considers risk assessment due to uncertainty of demand and renewable energy when the NMGs are operated in isolated mode and schedules ancillary service transactions when the NMGs are connected to the power grid. The NN predicts the schedule of diesel generators, fuel cell (FC) and the battery energy storage system (BESS) in both isolated and gird-tied modes. The merit of the proposed method is that the virtual model (NN) can interact with the physical model (NMGs) in a real-time manner that depends on its operational mode. Restated, the virtual model can provide real-time dispatch updates in the schedule of conventional generators, FC and BESS. A real-time digital simulator (Opal-RT eMegasim) was used to validate the proposed method by testing a modified CIGRE benchmark model and a modified IEEE 34-bus system.

New twists of a TAIL: novel insights into the histone binding properties of a highly conserved PHD finger cluster within the MLR family of H3K4 mono-methyltransferases.

Enhancer activation by the MLR family of H3K4 mono-methyltransferases requires proper recognition of histones for the deposition of the mono-methyl mark. MLR proteins contain two clusters of PHD zinc finger domains implicated in chromatin regulation. The second cluster is the most highly conserved, preserved as an ancient three finger functional unit throughout evolution. Studies of the isolated 3rd PHD finger within this cluster suggested specificity for the H4 [aa16-20] tail region. We determined the histone binding properties of the full three PHD finger cluster b module (PHDb) from the Drosophila Cmi protein which revealed unexpected recognition of an extended region of H3. Importantly, the zinc finger spacer separating the first two PHDb fingers from the third is critical for proper alignment and coordination among fingers for maximal histone engagement. Human homologs, MLL3 and MLL4, also show conservation of H3 binding, expanding current views of histone recognition for this class of proteins. We further implicate chromatin remodeling by the SWI/SNF complex as a possible mechanism for the accessibility of PHDb to globular regions of histone H3 beyond the tail region. Our results suggest a two-tail histone recognition mechanism by the conserved PHDb domain involving a flexible hinge to promote interdomain coordination.

Fiscal Decentralization and Human Development in Selected Developing Countries in Asia: Role of Institutionali

The paper aims to investigate the impact of fiscal decentralization on human development and moderating role of political institutions in selected Asian countries for the time period 1990-2019, applying panel data Fixed and Random Effects models. The empirical findings show that fiscal decentralization at both the provincial and local levels significantly affects human development. The optimal level of fiscal decentralization is computed at 1.143 and 0.229, respectively, suggesting that fiscal decentralization above this level may revert the results for human development. The non-linear specification of the model also portrays a rising human development in the wake of fiscal decentralization but at a decreasing rate. Moreover, the role of institutionalization is proved effective in the case of the countries where provincial-level decentralization is controlled in the model. The results imply that a lack of proper coordination and mismanagement due to many governance tiers can subside human development. However, fiscal decentralization is an essential factor for Asian countries to increase the efficiency of the public sector if supported with a controlled decentralization at the sub-national level.JEL Classification: H50, H70, O15

Disaster Management by Security Agencies in Nepal

As per the MOHA report (2021), disaster has been claiming life and property of people. MOHA has its plan to tackle the Disaster because of the fact that Nepal is a disaster-prone country. The categories of disaster as per MOHA report, 25 types of disasters have been happing in Nepal and causing loss of life and property of people. In this context, this article aims to find out the situation of disasters in the country as whole and province-wise scenarios of disaster cases; examine the sufficiency of security personnel to implement the disaster policy mandate given by the government of Nepal and elucidate the required coordination for preparedness, responses and rescue operations that have to carry out by the security agencies in support of three tiers of governments. For this purpose, secondary data from the MOHA web pages were retrieved to analyze the interrelationship of each disaster. Likewise, policies related to preparedness and response in general, especially to security agencies were reviewed. Key informants (KI) interview was taken to consolidate findings from the secondary data. Koshi Province is in the top position of the disaster cases whereas Sudurpaschhim Province is at the lowest position out of 26148 disaster cases from 2011 to 2021 June. Despite the deficiency of human resources in the security agencies and the lack of proper coordination made by the three tiers of government, security agencies accomplish the roles of preparedness, response and rescue operation more than their capacity to save life and property of people. The study concludes that disaster management is not the government's priority whatever its claim in government policy documents due to lack of appropriate coordination with the security agency and insufficient security personnel. The coordination and ensuring of required security personnel is the responsibility of the government when it concerns disaster management by the security agencies in Nepal.

Peace Building in Africa

Africa has been the theatre of conflicts since the end of the Cold War. Intra-state conflicts have particularly taken a heavy toll on human lives in the past two decades. The state of insecurity in the continent has retarded socio-economic and political goals and set the continent decades back in all development indices. Consequently, Africans have witnessed unprecedented levels of misery and human suffering. This makes peace building an important engagement in the continent as a necessary tool to re-establish security and initiate the process of nation-building in war ravaged countries in the continent. This paper is a contribution to the debate on the place of peace building in a troubled continent. The analysis is dependent on secondary sources: the internet, textbooks, newspapers and magazines. The paper discussed the roles of local level involvement, government/state institutions and international partners and organizations in peace building in Africa. Identified challenges to peace building are the conception of peace building as a post conflict engagement by the international community, lack of capacity and proper coordination, lack of resources and external influence, and control of the process and programmes. To surmount these challenges, the paper recommended the involvement of local actors in the design and implementation of peace building programmes, indigenous capacity building, and central coordination of peace building initiatives.

Review of Gully Erosion in Anambra State: Geology, Causes, Effects, Control Measures and Challenges Associated with Its Mitigation

In South-Eastern Nigeria, particularly in Anambra State, gully erosion presents a serious environmental challenge. With over 100 gully sites in the state, only about 30 have received measures of control but are still not fully under control. Observations have shown clearly that the underlying geology exerts major control over the development of gully erosion in the study area. Progressive gullies in certain areas of Anambra State are caused by various factors, including topography, soil and water pH, lithology type, deforestation, hydrogeology, and geotechnical rock properties. This erosion activity has resulted in the loss of productive lands, water pollution, sedimentation of waterways, and the loss of lives and properties almost every year. However, several government agencies have attempted to manage it using concrete structures, stabilization work such as planting bamboo and cashew trees to increase water intake, and pipe structures to channel the water directly to nearby surface waters through the construction of check dams, embankments, and retention ponds to control the flow of water and sediments. Despite these control efforts, several challenges persist in effectively managing gully erosion in Anambra State. Majority of the concrete structures used to control these gullies have collapsed, leading to the incessant spreading of the site. Inadequate funding, failure of engineering structures, flooding, the geologic setting of the area, limited technical expertise, population growth, urbanisation, a lack of public awareness, and a lack of proper coordination among stakeholders hinder the implementation of comprehensive erosion control measures. It is recommended that concrete drainage channels should not only be used in controlling these gullies but also be integrated with other measures to yield a positive result.