This study examined the relationship between COVID-19 School Reopening Managerial Strategies and Effective Administration of Post Basic Schools in Adamawa State, Nigeria. Three research questions and three hypotheses guided the study. The population of the study comprised 322 principals and 5734 classroom teachers in Post Basic Schools in Adamawa State, giving a total population of 6056. The sample size is 705 comprising of 130 principals and 575 teachers. This study adopted a correlational research design. Two self-structured instruments were used for data collection for the study. The two two self-structured questionnaires tagged “Covid-19 School Reopening Managerial Strategy Questionnaire (COVID-19 SRMSQ) and “Effective Administration of Post Basic Secondary Schools Questionnaire” (EAPBSQ) were used in collecting data for the study. Cronbach Alpha Statistic was used to ascertain the internal consistency of the items of the instruments. An overall reliability coefficient of 0.86 and 0.83 were obtained for the both instruments. Descriptive statistics of mean and standard deviation were used to answer the research questions using the real limit of numbers. The Pearson Product Moment Correlation Coefficient was used to test the null hypotheses 1 & 2. While, Multiple Regression Analysis was in testing hypothesis 3. The findings of the study revealed that there is significant relationship between wearing of face mask and effective administration of Post Basic Schools in Adamawa State (r – value = 0.304, p <0.05). There is a significant strong correlation between adherence to social distance and the effective administration of post-basic schools in Adamawa State (r = 0.543, p < 0.05). The results revealed that wearing face mask and adherence to social distance are significant predictors of effective administration of Post Basic Schools in Adamawa State, F(5, 703) = 33055.330, p < 0.05. Since the p – value (0.000) is less than 0.05 alpha level, we can conclude that the null hypothesis should be rejected. This means that wearing face mask and adherence to social distance significantly predict effective administration of Post Basic Schools in Adamawa State. Based on the findings of the study, the following recommendations among others were made; government should make provision for free face mask to teachers, students and visitors within the school premises so as to further curtail the spread of the dreaded covid-19 pandemic within schools and its host community. Government should make provision for safety materials (hand sanitizers; also known as hand antiseptic, hand disinfectant, alcohol-based hand sanitizers, hand rub, soap and water) for promotion of better hygiene (hand Sanitization) culture in secondary school in the state for the purpose of removing common pathogens (disease-causing organisms) in order to remove all types of germs from hands.