The construction industry in Cameroon is facing increasing pressure to adopt more sustainable practices to mitigate environmental degradation and promote energy efficiency. This article explores the potential of straw as an eco-sustainable building material, particularly in the context of contemporary architecture in Garoua- Cameroon. Straw, a renewable resource, offers several benefits, including low embodied energy, excellent thermal insulation, and local availability, making it an ideal material for sustainable construction in the region. This article reviews global examples of straw-based architecture, examines the advantages and challenges of using straw in construction, and proposes practical applications for straw in Cameroon. Finally, it discusses the implications of adopting eco-sustainable practices in the country’s construction industry and highlights the need for updated building regulations and training programs to support the wider use of alternative building materials.