Abstract The purpose of the study was to identify the mediating effects of self-efficacy between job-stress and depression in regional hospitals' workers. The data of this study were collected from 700 hospitals' workers who have been working in 306 hospitals in B city. And the data were collected from Feb. to May 2012. To determine the impact of self-efficacy on job-stress and depression for men and women workers in local hospitals, we measure self-efficacy, job-stress and depression of workers and analyze their relationships. There was a negative relationship between self-efficacy and job-stress(r=-.238, p<.001), depression(r=-.626 p<.001). Verifying the mediating effects of self-efficacy to the impact of job stress on depression, the mediating effects of self-efficacy were significant. It suggests that there is a need to relax the negative impact of job stress through the promotion of self-efficacy for individual or team-level organization. Key Words : Depression, Job-stress, Mediating Effect, Self-efficacy