More attention is being given to researches of eco-sustainable solutions to be implemented in agriculture, particularly in the presence of plant parasitic nematodes, whose damages have significant global importance. Unsustainable practices, such as fumigation and monoculture, have led to depletion of biodiversity, allowing harmful trophic groups (bacteria, fungi, and nematodes) to prevail, and their negative synergistic action further exacerbating yield losses. Considering the notable and progressive restriction of usable molecules, nematode control strategies must necessarily consider the appropriate integration of methods. The main objective of control is to limit pathogen populations below the damage threshold, rather than aiming at their eradication as mistakenly pursued in the past. This goal can be achieved with the help of solutions that promote plant development through biostimulation of root systems, which are often affected by various organisms in the biosphere. Tequil, through its well-documented synergy of saponins, tannins, and polyphenols, produces invigorating, biostimulating, and strengthening effects on the root system. Indeed, in vitro tests and field trials have highlighted Tequil’s appreciable activity in containing trophic groups, particularly root-knot nematodes of the Meloidogyne genus. Therefore, its use could indirectly contribute to nematode control and limit yield losses. Key Words: Quillaja saponaria, nematodes, bio stimulation, biocontrol, abiotic stresses resistance.