Health Promotion Care Research Articles

Health policy analysis for stewardship of rehabilitation services

Background and aimThere have been a growing interest in investigating the effect of stewardship on other functions of rehabilitation service delivery. Effective stewardship of rehabilitation services can ensure that these services are of high quality, accessible, affordable, and sustainable, and can help achieve the goals of universal health coverage. The purpose of this study was to identify and analyze the policies adopted in the field of rehabilitation services in Iran and in the international arena, and finally to identify policy gaps, areas for improvement, and areas that have been overlooked.MethodThis research is a policy analysis, carried out through document analysis and Dalglish et al.’s READ approach. Data were analyzed and interpreted using qualitative methodology and directed content analysis. For this purpose, Veillard et al.‘s health system stewardship framework was used to analyze the stewardship of rehabilitation services. The dimensions of the stewardship framework, were: Defining the vision for health and strategies and policies to achieve better health; influencing all sectors and advocating for better health; ensuring good governance in line with prevailing values; ensuring the alignment of system design with health system goals; improving existing legal and regulatory instruments; and compiling, disseminating, and applying information. Scott’s four criteria were used to assess the authenticity, credibility, representativeness, and meaning of the documents. Those that did not meet even one of the Scott’s criteria were excluded from content analysis.FindingsA total of 16 documents were identified, all of which met Scott’s criteria and none were excluded from the study. A total of six themes and 56 subthemes were extracted. The contents of all the documents were extracted under six themes of Veillard et al.‘s health system stewardship framework. Overall, the results show that national documents place greater emphasis on the development of preventive healthcare and health promotion. Documents often focus on engaging NGOs and the families of people with disabilities and on intersectoral collaboration for knowledge production and the development of intersectoral knowledge networks. In terms of health system governance in line with prevailing values, documents are mainly focused on health system stewardship by the Ministry of Health and on evidence-based decision-making with the participation of target groups. Also, documents place more emphasis on upgrading the national infrastructure and increasing access to rehabilitation services.ConclusionIn some areas of rehabilitation services, there is a gap between national documents, which reflects differences in priorities, approaches, resources, and instruments available to strengthen rehabilitation services at the national and international levels.

Guidance on health promoting and climate-friendly hospitals and health services

Abstract The negative impacts of climate change on health and the healthcare system are becoming increasingly evident. The healthcare sector, which accounts for nearly seven percent of Austria’s CO2 emissions, contributes to the exacerbation of climate change on one hand, but is also affected by its consequences on the other. To meet these challenges, it is necessary for healthcare facilities to both adopt climate-protective measures and adapt to the changed conditions. A project launched in 2023, supported by the Austrian Health Promotion Agenda and in cooperation with the Austrian Network of Health Promoting Hospitals and Health Services, has shown that there is a need for support in implementing climate protection measures in healthcare facilities. In response, the WHO Collaborating Centre for Health Promotion in Hospitals and Healthcare, located at the Competence Centre for Health Promotion and Healthcare at the Austrian National Public Health Institute, will work on the development of standards based on international models to support healthcare facilities in the introduction of climate-friendly practices until 2026. The methodology of the project includes the analysis of existing quality criteria and instruments, as well as a modified Delphi process with two rounds of online questionnaires directed at an international panel of experts. After each round, exchange meetings with a smaller group from the panel take place to achieve consensus. Based on the research findings and the Delphi consultations, a draft of standards and an implementation manual will be created. These drafts will be piloted in various healthcare facilities in Austria and other countries to assess their practicability and effectiveness. Following the pilot tests, the standards and the manual will be revised to integrate the practical insights gained. At the time of the conference, the initial results of the Delphi process will be presented, providing insights for the further development of the standards. Key messages • Integrating climate-friendly practices into all aspects of healthcare can reduce its environmental impact, improve health outcomes, and contribute to the broader sustainable development goals. • Climate-friendly approaches yield significant health, economic, and social co-benefits.

Organizational health literacy responsiveness in community pharmacies in Serbia

Abstract Background The Faculty of Pharmacy at the University of Belgrade conducted a pilot study at community pharmacies in Serbia in 2023 in the framework of the M-POHL organizational health literacy (OHL) project. Community pharmacies in Serbia are considered relevant settings where people’s health can be promoted within the organization. Methods The validated and culturally adopted Serbian version of the International Self-Assessment Tool for Organizational Health Literacy in Primary Health Care Services (OHL-PHC) was used. We recruited employees from 3 pharmacy chains with pharmacists from different units. A preparatory workshop was organized to explain the procedure and the concept of OHL. First, the self-assessment was performed in a small group of 5 persons individually, and then the results were discussed in a joint assessment. The self-assessment was based on the degree of fulfillment of 4 categories offered for each indicator: not fulfilled (0-25%), predominantly not fulfilled (26-50%), predominantly fulfilled (51-75%), and completely fulfilled (76-100%). The same scale was applied for the indicators, sub-standards and standards and the final score was the mean of the individual scores (min. 0, max. 4). Results The overall score of the OHL on the sample level was 1.93±0.86, with the highest score for providing of easy access to primary care service and facilitating navigation (2.3±0.5). The least fulfilled standards were related to promotion of digital health literacy and promoting health literacy with the same score values of 1.7±1.0. Out of 69 indicators 1 had been self-assessed as not fulfilled and 15 reached low consensus (SD ≤ 1), and needed to be discussed further. Conclusions Improvements in OHL in the piloted institutions are necessary for successful healthcare and health promotion and could be tailed in further usage of the OHL-PHC on a broader scope. More pilot studies are needed in other healthcare settings at primary level in Serbia.

4.N. Scientific session: Equity in Child Health: Leveraging Universal Health Promotion Services for Families Amid Uncertainty

Abstract This workshop addresses the urgent need to foster resilience and equity in child health within the context of an increasingly uncertain Europe. Rapid societal changes, exacerbated by events such as the COVID-19 pandemic and heightened risks of conflict, climate change and economic instability, underscore the importance of nurturing environments where children can thrive despite challenging circumstances. The workshop aims to explore strategies for promoting well-being and addressing social inequalities in child health within the context of universal health promotion services, such as school health services and child health clinics. Objectives are to 1) Elucidate the importance and impact of universal health promotion services in addressing social inequalities and promoting equitable opportunities for all children, regardless of background or circumstance; 2) Identify actionable steps for interventions mitigating social inequalities and promoting equitable opportunities focusing on health literacy among parents with immigrant backgrounds; 3) Showcase successful models and initiatives in universal healthcare and health promotion services for children and families, emphasizing early intervention and standardized evaluation tools; and 4) Facilitate dialogue and knowledge exchange among professionals, policymakers, and stakeholders involved in child and adolescent health promotion. This workshop’s added value lies in its multidisciplinary approach, fostering collaboration for innovative solutions in child health resilience and equity. The coherence between presentations lies in their joint focus on addressing social inequalities in the context of universal health promotion services for children and families. Each presentation offers a unique perspective on these themes, contributing to a comprehensive understanding of the challenges and opportunities in child health promotion. • Hanne Nissen Bjørnsen’s presentation on the role of universal services in public health and addressing social inequality sets the stage by examining the structural factors contributing to disparities in child health outcomes. • Kirsti Riiseŕs presentation conveys the importance of user, stakeholder, and community involvement in creating culturally sensitive strategies for effective health promotion services in the context of health literacy among parents with immigrant backgrounds • Kristin Haraldstad’s presentation on Starting Right, an evidence-based assessment of children in municipalities healthcare centers, highlights the importance of early intervention and targeted support in mitigating health inequalities and promoting well-being. Format of the workshop: Three 10-minute presentations followed by a 20-minute moderated discussion to delve into empowerment and equity in child health, encouraging rich idea exchanges. Key messages • Leveraging universal health promotion services effectively empowers children and families while addressing social inequalities amidst periods of uncertainty. • Collaborative, user-centered approaches and evidence-based working strategies are key to promoting equity and building resilience in child health.

2.E. Round table: Building climate resilient health systems in the EU

Abstract Climate change is one of the biggest challenges for modern society. The health effects of climate change lead to negative impacts on European health systems, and conversely, European health systems contribute significantly to climate change. To overcome challenges posed by the climate crisis, European cooperation is essential. The interdependencies between climate change and public health and its broader impact underline the importance of resilience in European health systems, calling for concrete actions from both EU institutions and national governments. Additionally, the topic of resilient health systems currently ranks high on the European agenda, with the Belgian Presidency promoting health care strengthening as one of its six priorities. The European Commission will also continue its work on this issue for the next five years. The EU has already taken steps in this matter, such as the launch of the European Health Union and the adoption of the EU4Health Programme. However, in order to better prepare for climate resilient health systems, the EU must further develop in this regard. To explore this pressing issue, the round table discussion will focus on how EU actions in climate adaptation can synergistically contribute to the resilience of health systems. Resilience, often associated with adaptation, embodies the capacity to anticipate, withstand, and recover from shocks and stresses related to climate change. By delving into this question, the workshop seeks to uncover ways in which EU and Member State climate initiatives can reinforce health system resilience, thereby fostering a more adaptive and responsive health workforce and infrastructure. Featuring 4 panellists from Erasmus University Rotterdam, the Austrian National Public Health Institute, the Dutch Green Healthcare Alliance and the European Environment Agency, the round table will bring together diverse perspectives on this issue. The added value of the round table is laying out possible ways of how both the EU and Member States can contribute to enhancing the resilience of European health systems. After establishing the necessity for action, the round table discussion will focus on generating ideas to address climate change. Specifically, this discussion will cover examples of national policies, such as from the Netherlands, Austria, and other Member States. Also discussed will be the importance of monitoring and surveillance, and conducting a health and vulnerability assessment. This ensures better understanding of the relevant current and future health impacts, which will inform resilience measures. This will be followed by a discussion with the audience to formulate recommendations for improving the resilience of EU health systems for the next five years. Key messages • Climate change challenges European health systems, emphasising the need for European cooperation in resilience efforts. • Synergising climate adaptation with health system strengthening enhances EU’s capacity for resilience. Speakers/Panelists Chiara Cadeddu Erasmus University Rotterdam, Rotterdam, Netherlands Aleksandra Kazmierczak European Environment Agency, Copenhagen, Denmark Andrea Schmidt Austrian Public Health Institute, Vienna, Austria Juliette Mattijsen Groene Zorg Alliantie, Rotterdam, Netherlands

COMMUNITY INTERVENTIONS TO REDUCE MATERNAL MORTALITY IN LOW-RESOURCE AREAS

Maternal mortality, defined as the death of women during pregnancy, childbirth or in the postpartum period, continues to be a serious public health problem, especially in low-resource areas. Factors such as limited access to quality healthcare, lack of infrastructure, shortage of qualified professionals and socio-economic inequalities contribute to high mortality rates. In many of these regions, community interventions have been key to reducing maternal mortality by providing direct assistance to pregnant women, promoting health care education and strengthening the link between communities and medical services. This study seeks to analyze community interventions implemented in low-resource areas to reduce maternal mortality, evaluating their strategies, challenges and the results obtained in improving maternal survival rates. This study is a systematic review that investigates the effectiveness of maternal health interventions in low- and middle-income countries, focusing on skilled birth attendant programs, community transport, and technological innovations. The analyses were carried out in databases such as PubMed, BMC Pregnancy and Childbirth and African Journal of Reproductive Health, using data from articles published between 2015 and 2021. Community interventions to reduce maternal mortality range from health education programs, training traditional birth attendants and strengthening maternal and child support networks. One of the main approaches involves training community health agents, who work directly in communities, providing basic prenatal care, referral to medical services in cases of risk and promoting knowledge about signs of pregnancy complications. These actions are especially important in remote areas, where access to health facilities is limited. Another key aspect of these interventions is the promotion of safe practices during childbirth and the strengthening of emergency transport systems, ensuring that pregnant women at risk can be transferred to health centers equipped to deal with complications. The introduction of simple technologies, such as clean delivery kits and essential medicines, has shown promising results in reducing infections and hemorrhages, which are primary causes of maternal mortality. Awareness campaigns also play a crucial role, educating the population about the importance of prenatal care, proper nutrition and birth assistance in controlled environments. These initiatives aim not only to improve knowledge about maternal health, but also to combat cultural and social barriers that can prevent pregnant women from seeking medical care in a timely manner. It is concluded that community interventions have proven to be an effective approach to reducing maternal mortality in low-resource areas. Training health workers, implementing safe delivery practices and raising awareness about antenatal care are strategies that have contributed significantly to improving maternal health outcomes. However, for these interventions to be sustainable and scaled up, continued public policy support, adequate funding and the integration of these actions with formal health systems are essential.

Screening of anti-diabetic potential of the siddha formulation sambirani poo kuligai by in-vitro alpha glucosidase enzyme inhibition assay

Background: Noninsulin-dependent diabetes mellitus (NIDDM) is a common disease of the endocrine system caused by the decreased secretion of insulin by the pancreatic Langerhans beta cell or by the lowering of insulin resistance due to excessive absorption of glucose. The Siddha system of medicine is a traditional medical system that uses a scientific and holistic approach to provide preventive, promotive, curative, rejuvenative and rehabilitative health care. According to Siddha literature, diabetes is known as Innippu Neer, Madhumegam and Neerizhivu. The various reasons for the cause of this disease are attributed to foodhabits and lifestyle changes and also due to hereditary causes. One of the therapeutic approaches is to decrease the postprandial hyperglycemia by retarding the absorption of glucose through the inhibition of carbohydrate-hydrolyzing enzymes, such as a-amylase and ?-glucosidase. ?-Glucosidase are enzyme that catalyze the absorption of digested glucose from dietary polysaccharides in the small intestine. Aim: The aim of the present study is to evaluate the anti-diabetic potential of the siddha formulation of Sambirani Poo Kuligai(SPK) by alpha glucosidase enzyme inhibition assay. Method: The spectrophotometric assay method was used to find alpha glucosidase inhibitory activity. Results: SPK showed presence of alpha glucosidase inhibitory potential with the maximum inhibition of about 41.74 ± 3.578 % and the corresponding IC50 is 606.5 ± 49.51?g/ml. Conclusion: This in-vitro study revealed the presence of the alpha glucosidase activity in the siddha formulation Sambirani Poo Kuligai possesses antidiabetic activity

Pediatric Kidney Donation and Transplantation in Kingdom of Saudi Arabia.

The evolution of pediatric kidney donation and transplantation in the Kingdom of Saudi Arabia underscores the transformative effects of strategic initiatives and institutional reforms aimed at fostering self-sufficiency and ethical stewardship in transplantation. The ascendance of the Saudi Center for Organ Transplantation as a regional hub for organ procurement and transplantation is a testament to Saudi Arabia's commitment to advancing health care delivery and promoting international collaboration in combating organ trafficking and commercialism. Moving forward, sustained investments in infrastructure, capacity building, and regulatory oversight will be paramount to addressing emerging challenges and consolidating Saudi Arabia's position as a global leader in transplantation. By prioritizing patient welfare, ethical principles, and operational excellence, Saudi Arabia is poised to shape the future trajectory of pediatric kidney transplantation and usher in a new era of health care innovation and equity within the region and beyond.

Nurses' health promotion practices in rural primary health care in Nigeria. A qualitative study.

Nurses play a vital role in providing high-quality primary healthcare and health promotion services. The state of research highlights their often complex operational realities and shows the need for an evidence-based understanding of nurses' perspectives on health promotion practices, especially in low-resource settings. This study focuses on how community health nurses in rural primary healthcare centers in Nigeria perceive their health promotion role and the opportunities and challenges of, and potential entry points for strengthening, their practice. A sample of 10 nurses from eight rural primary healthcare centers in eight local government areas of Anambra state, Nigeria, was purposively selected. Data were collected via semistructured telephone and written interviews and analyzed by qualitative content analysis using a deductive-inductive approach. Nurses emphasized their commitment to supporting patients and communities to develop skills and take control of their own lives. Nurses described their role as facilitators of behavioral and environmental change, individual and community empowerment facilitators as well as social activists. Factors that enhance the health promotion practice of nurses include adequate skills, sufficient human and material resources and community support and participation. Inhibiting factors included insufficient funding, poor working conditions, staff shortages, high workload, lack of training opportunities and low participation of community members. Overcoming challenges and facilitating health promotion activities in rural communities require bolstering nurses by providing further training opportunities for enhancing their health promotion competencies and creating supportive environments. Future research should focus on how to strengthen nurses' health promotion efforts through interprofessional and intersectoral collaboration.

A DATA DRIVEN APPROACH THROUGH IOMT BASED PATIENT HEALTHCARE MONITORING SYSTEM

The current circumstances underscore the pressing need to accelerate the adoption of Internet of Things platforms in realm of the medical field to improve the health of mankind. Given the present challenges, I propose the development of an Advancing healthcare monitoring system built on the foundation of Internet of Medical Things (IOMT). Advancing patients healthcare IOMT system serves as a communication conduit between patients and doctors, facilitated by the IoMT platform. This platform utilizes various medical sensors connected to a server through technologies such as WiFi and Bluetooth. The data collected and stored in the server is then leveraged to analyse patients' health conditions, guiding subsequent treatment protocols. In this proposed system, the microcontroller serves as an intermediary interface between the sensors and the server. This cutting-edge technology enables remote patient monitoring, eliminating the need for physical presence. Within the prototype, patients' summaries and information is supplied using an online platform. Through the adoption of Advancing Healthcare through Data-Driven IOMT Patient Monitoring, lives can be safeguarded from critical conditions, underscoring the vital importance of embracing such advanced technologies in healthcare.

Advancing healthcare through piezoresistive pressure sensors: a comprehensive review of biomedical applications and performance metrics

Abstract Piezoresistive pressure sensors have transformed biomedical applications, enabling precise diagnostics and monitoring. This concise review explores the fundamental principles, key components, and fabrication techniques of piezoresistive pressure sensors, focusing on critical performance metrics such as sensitivity, accuracy, and response time. Biomedical design challenges, including biocompatibility and long-term stability, are examined, offering insights into solutions for optimal sensor integration. In diverse biomedical applications, piezoresistive pressure sensors play pivotal roles, from blood pressure monitoring to implantable medical devices. The paper emphasizes their versatility in enhancing patient care through continuous and accurate monitoring. Looking forward, the review discusses emerging trends and potential research directions, positioning piezoresistive pressure sensors as central contributors to the future of biomedical technology, promising improved patient outcomes and advanced healthcare delivery through precise and continuous monitoring.

The Frontier Exploration of the Development Trend of Key Technologies in Digital Healthcare in Medical Big Data Analysis

With the rapid development of medical big data, digital healthcare as an interdisciplinary field is gradually transforming the traditional healthcare model, continuously advancing the realization of personalized medical services and remote health monitoring. This paper systematically reviews 138 research articles related to the development trends of key technologies in digital healthcare, exploring various critical areas including digital health and privacy security, the application of artificial intelligence and machine learning in health, remote monitoring and mobile health, medical data analysis and electronic health records, and the ethical and policy challenges in digital health. Studies indicate that the improvement of privacy security measures and efficient medical data processing technologies are the foundation for the safe promotion of digital healthcare; Artificial intelligence and machine learning technologies play an important role in enhancing the accuracy of diagnosis and disease prediction. Meanwhile, mobile health and remote monitoring technologies show great potential in improving the accessibility and continuity of medical services. In addition, this paper discusses the challenges of ethics and policies in digital health practice, such as data sharing, conflicts of interest, and respect for patient privacy. Future research must focus on refining technological solutions to address these challenges and fully integrate digital healthcare technologies into clinical practice.

Euthymia, Psychological Well-Being, and Professional Quality of Life in Health Care Workers.

Euthymia is a transdiagnostic construct characterized by the presence of positive mood states, psychological flexibility and resilience. These components contribute to psychological wellbeing and support mental functioning. Exposure to suffering and high levels of stress can lead to the onset of burnout and secondary traumatic stress, but also lack of compassion satisfaction. The study aimed to test the existing relationships between euthymia, psychological well-being, and factors associated with quality of life of healthy participants involved in medical settings. The sample was composed of 177 healthy participants involved in medical settings, 118 women (66.7%) and 59 men (33.3%) aged between 19 and 69 years old (mean = 27.16; SD = 8.47). Standardized psychodiagnostics instruments were used to assess euthymia (Euthymia Scale-ES), psychological well-being (The Well-Being Index scale-WHO-5) and the quality of life of the involved participants (Professional Quality of Life Measure-ProQOL-5). The results showed that gender, well-being and psychological well-being were predictors of compassion satisfaction and secondary traumatic stress. Specifically, female gender predicted higher levels of compassion satisfaction. Well-being and psychological flexibility predicted higher levels of compassion satisfaction and lower secondary traumatic stress. Psychological well-being predicted higher levels of compassion satisfaction. Promoting euthymia and well-being helps individuals to preserve psychological well-being and increase tolerance to stressful life situations. Results highlighted the need for promoting health care professionals' euthymia and well-being. In line with evidence, encouraging interventions based on evidence appears relevant.

Translation and cross-cultural adaptation of the Chinese version of the HLS-EU-Q47.

The development of health literacy in China is relatively slow, and there are fewer health literacy scales, which is difficult to measure. Therefore, this study aims to promote the development of health literacy in China through the translation and application of the European Health Literacy Survey Questionnaire (HLS-EU-Q47). The scale was translated into Chinese, back-translated, culturally adapted and finally subjected to psychometric evaluation. A multi-stage stratified sampling method was used to select 2504 residents to test the reliability and validity of a questionnaire on health literacy. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to evaluate the validity of the results, and the back consistency was calculated by Cronbach's alpha coefficient. The EFA revealed that health care, disease prevention and health promotion explained 78.68% of the total variance in health literacy. The scale and its subscales demonstrated strong internal consistency, with high Cronbach's alpha coefficients ranging from 0.947 to 0.983. CFA confirmed the three-factor model's goodness-of-fit for the Chinese population. The dimensions of healthcare, disease prevention and health promotion showed high convergent validity with an average variance extracted values ranging from 0.52 to 0.60 and composite reliability values ranging from 0.94 to 0.96. The reliable and valid Chinese version of the HLS-EU-Q47 (HLS19-Q47-CN) developed and evaluated in this study is an important tool for assessing health literacy levels in the Chinese population. Furthermore, as this tool has global applicability, it has the potential to assess health literacy levels across different countries, enabling practical international comparisons.

Integrating Artificial Intelligence into Biomedical Science Curricula: Advancing Healthcare Education.

The integration of artificial intelligence (AI) into healthcare practice has improved patient management and care. Many clinical laboratory specialties have already integrated AI in diagnostic specialties such as radiology and pathology, where it can assist in image analysis, diagnosis, and clinical reporting. As AI technologies continue to advance, it is crucial for biomedical science students to receive comprehensive education and training in AI concepts and applications and to understand the ethical consequences for such development. This review focus on the importance of integrating AI into biomedical science curricula and proposes strategies to enhance curricula for different specialties to prepare future healthcare workers. Improving the curriculum can be achieved by introducing specific subjects related to AI such as informatics, data sciences, and digital health. However, there are many challenges to enhancing the curriculum with AI. In this narrative review, we discuss these challenges and suggest mitigation strategies.

The knowledge, attitude, and intention to use internet-based mental health services: A serial mediation model

ObjectiveInternet-based mental health services (i-MHS) have been widely provided to the public during the pandemic. However, people's engagement with i-MHS remains unclear. This study aimed to examine the Chinese population's knowledge, attitudes, and use intentions regarding i-MHS and determine their relations by serial mediation models. MethodsThe public's knowledge, attitudes, intention to use i-MHS and psychological impact of the pandemic were assessed. An online survey was administered to respondents from mainland China (N = 2543). ResultsOf the participants, 53.9 % exhibited some familiarity with i-MHS, while 62.4 % perceived these services as somewhat or very helpful, and 53.2 % were willing or very willing to use them. Serial mediation analyses indicated that the psychological impact of the pandemic indirectly related to the intention to use i-MHS. Knowledge and attitudes toward i-MHS sequentially mediated this relation [χ2(61) = 179.359, P < .001; χ2/df = 2.940; CFI = 0.996; RMSEA = 0.028]. ConclusionsThis study underscores the critical role of knowledge in shaping positive attitudes and intentions to use i-MHS, emphasizing the need for robust mental healthcare promotion strategies to raise knowledge and maximize the benefits of i-MHS.

Single-cell transcriptome profiling highlights the importance of telocyte, kallikrein genes, and alternative splicing in mouse testes aging

Advancing healthcare for elderly men requires a deeper understanding of testicular aging processes. In this study, we conducted transcriptomic profiling of 43,323 testicular single cells from young and old mice, shedding light on 1032 telocytes—an underexplored testicular cell type in previous research. Our study unveiled 916 age-related differentially expressed genes (age-DEGs), with telocytes emerging as the cell type harboring the highest count of age-DEGs. Of particular interest, four genes (Klk1b21, Klk1b22, Klk1b24, Klk1b27) from the Kallikrein family, specifically expressed in Leydig cells, displayed down-regulation in aged testes. Moreover, cell-type-level splicing analyses unveiled 1838 age-related alternative splicing (AS) events. While we confirmed the presence of more age-DEGs in somatic cells compared to germ cells, unexpectedly, more age-related AS events were identified in germ cells. Further experimental validation highlighted 4930555F03Rik, a non-coding RNA gene exhibiting significant age-related AS changes. Our study represents the first age-related single-cell transcriptomic investigation of testicular telocytes and Kallikrein genes in Leydig cells, as well as the first delineation of cell-type-level AS dynamics during testicular aging in mice.

Improving patient-centered mental health promotion in primary care in vulnerable communities through mindfulness training in Rio de Janeiro, Brazil.

Brazilian Primary Health Care (PHC) is responsible for all-sanitary actions for a community-based population, including health promotion and mental health care. Mindfulness Based Health Promotion (MBHP) is an intervention that can promote self-care and psychosocial support in PHC. To discuss the effects of mindfulness based psychosocial group interventions for health promotion in primary care units in Rio de Janeiro, Brazil. The intervention was based on the MBHP model adapted for SUS. Nine groups were held in Rio de Janeiro. A quali-quanti research was held with two parts: (a) quantitative study, pre and after the 8 weeks intervention, evaluating the effect on mindfulness and self-compassion and their association with levels of anxiety, depression, and quality of life. (b) Qualitative research using Focus Groups with the participants to investigate their experience at the end of the mindfulness groups. Sixty-two participants finished the 9 groups where 86% were women, mostly between 30 and 59 years of age and low income, and around 80% under regular medical care in PHC in SUS. In the studied sample 80% had at least one chronic health condition under treatment, including 42% with anxiety and 35% with depression. The effects included significant improvement in Anxiety and Depression and in Quality of Life, mainly in the psychological but also in the physical and interrelation domains. The qualitative study showed that most patients joined the group on the recommendation of health professionals for managing physical and mental health symptoms. Patients reported being able to use the practices taught in the sessions to manage symptoms such as insomnia and emotionally distressing situations in their daily lives. Including family members in mindfulness practices was a strategy to negotiate not only a space at home to meditate, but also to obtain a different approach to health problems. Participants pointed to mindfulness as a complementary therapeutic option to medication and psychotherapy. Mindfulness-Based Intervention have shown to be a feasible, well-accepted and efficacious method of offering psychosocial support and promoting well-being for low-income patients in primary care in LAMIC.

Analysis of the Application of the "14th Five-Year Plan" for the Development of Traditional Chinese Medicine in Grassroots Hospitals in the Post-Epidemic Era

The application of TCM treatment methods provided important support for the prevention and treatment of COVID-19 and also brought opportunities for the development of TCM. In the post-pandemic era, the good effects of traditional Chinese medicine have enabled its promotion and application in primary healthcare, laying the foundation for the development of traditional Chinese medicine policies. With the promulgation and application of plans such as the "14th Five Year Plan" for the development of traditional Chinese medicine, this article studies the existing problems and provides corresponding suggestions based on the specific content and application overview of the policy. The problem is that there are discrepancies between the formulation of plans and the actual situation in the region and insufficient specific management efforts in the implementation of plans during the policy implementation process. Based on this, this article proposes the following suggestions. Improvements need to be made from three aspects: establishing an effective management system that is lacking, strengthening education and publicity efforts, and coordinating and planning various development matters.

Self-efficacy and Perceived Ease of Use as Factors to Determine Medical Personnel Readiness to Use an Information System Technology

This article uses an empirical investigation to evaluate self-efficacy and perceived ease of use as factors that will determine the successful adoption of the health information system in health institutions, using Nigeria as a case study. The health information system is the application of information technology to enable and promote health care services provision, support and delivery. Utilizing the DeLone and McLean model and a construct from the TAM (Technology Acceptance Model), the focus is on self-efficacy and perceived ease of use which are tested with the (intention to) Use to find a correlation, to consider them as determinant factors of the readiness to adopt an information system in the healthcare environment. Results and findings reveal that self-efficacy and perceived ease of use have an effect on the intention to use and actual use of the HIS. Health practitioners should be trained on how to utilize the information system in order to improve their attitudes and perceptions towards it. Doing this will increase their zeal and make it habitual for them to utilize the system, hence better goals will be attained.