Patient behavior changing through adherence therapy is very difficult. Identifying the most effective approach is very important regarding adherence. Motivational Interviewing (MI) is a clinical approach involving communication, collaboration, evocation, autonomy and increasing motivation alongside the final results of behavior change. The principles underlying MI include empathy, developing differences, avoiding debate and supporting self-efficacy. MI interventions allow for the changing of the relevant cognitions and self-regulation processes that leads to adherence to the treatment. Method: A literature review was conducted focused on journals published between 2013 and 2018. Fifty relevant journals were obtained and data was extracted from 25 relevant selected journals. The search was carried out by entering the keywords ‘adherence’, ‘motivation’ and ‘MI’ into the SCOPUS, ScienceDirect, Sage, ProQuest, Elsevier, SpringerLink and Google Scholar databases. Conclusion: MI studies show that MI-based interventions are effective in promoting health behavior changes. It is also associated with positive health outcomes such as low blood pressure, diet, decreased smoking, lower cholesterol, and better blood sugar control. Keywords: adherence, motivation, MI