This research presents a bibliometric review of scientific production on the social and economic factors that influence mortality from tuberculosis between the years 2000 and 2024. The analysis covered 1742 documents from 848 sources, revealing an annual growth of 6% in scientific production with a notable increase starting in 2010, reaching a peak in 2021. This increase reflects growing concern about socioeconomic inequalities affecting tuberculosis mortality, exacerbated in part by the COVID-19 pandemic. The main authors identified in the study include Naghavi, Basu and Hay, whose works have had a significant impact on the field. The most prominent journals in the dissemination of this research are Plos One, International Journal of Tuberculosis and Lung Disease and The Lancet. The countries with the greatest scientific production include the United States, the United Kingdom, India and South Africa, highlighting a strong international contribution and a global approach to the problem. The semantic development of the research shows a concentration on terms such as “mortality rate”, “risk factors” and “public health”, with a thematic map highlighting driving themes such as “socioeconomic factors” and “developing countries”. The theoretical evolution reflects a growing interest in economic and social aspects to gender contexts and associated diseases. This study provides a comprehensive view of current scientific knowledge, identifying key trends and emerging areas for future research.