<h3>Objective</h3> Urinary cell cycle arrest biomarkers TIMP-2 & IGFBP7 are predictive for subsequent KDIGO-defined AKI, & diagnostic for subclinical AKI, after cardiac surgery. Early identification of a subclinical disease state allows implementation of renal protective measures, which reduce subsequent KDIGO-defined moderate–severe AKI. Following an innovation project, using biomarkers to guide use of a renal care bundle, we sought to assess the acceptability, feasibility & appropriateness of the intervention amongst clinicians. <h3>Design & Method</h3> If [TIMP-2]x[IGFBP7]>0.30ng/ml)2/1000 in cardiac patients 2h after ICU admission, they received a renal care bundle of: nephrotoxin cessation, advanced haemodynamic monitoring & protocolised optimisation, 12hrly serum creatinine & fluid balance, avoidance of hyperglycaemia, avoidance of radiocontrast agents, discontinuation of ACE inhibitors, & avoidance of starch/gelatine/chloride-rich solutions. Following conclusion of the project, the medical, surgical & nursing staff were surveyed to gauge acceptability of this assessment-intervention bundle. Two frameworks of acceptability were assessed. Questions based around Weiner's framework of acceptability elicited responses on a scale of high (5) to low degree (1) of acceptability, feasibility and appropriateness. The individual domains of Sekhon's acceptability score were assessed using separate questions, with an average percentage of agreement assigned to each domain (affective attitude, ethical consequence, patient & user experience, burden of intervention, intention and opportunity cost), before assessing correlation with general acceptability. <h3>Results</h3> Cardiac ICU nurses (63.2%; n=12), cardiothoracic surgeons (10.5%; n=2) and cardiac anaesthesiologists/intensivists (26.3%; n=5) were surveyed, with 89.5% (n=17) completing all questions. Across the four measures of acceptability, an average 83.8% of respondents assigned positive acceptable responses (4-5) with an average of 82.4% indicating a high degree of feasibility (4-5) and 85.3% reported the highest degrees (4-5) of appropriateness. For the Sekhon acceptability scale, there was 83.5% general acceptability. For the highest-scoring domains, strong correlation was seen between general acceptability and affective attitude (82.4%; R=0.79, p<0.001), and moderate correlation for user (81.2%; R=0.69, p=0.002) & patient (83.5%; R=0.65, p=0.005) experience, with weaker correlation for ethical consequences (83.5%; R=0.33, p=0.2). For those domains with lower degrees of acceptability, the domain of intention was moderately correlated with overall acceptability (71.8%; R=0.41, p=0.1), and burden (68.2%; R=0.38, p=0.14) and opportunity costs (69.4%; R=0.3, p=0.24) were weakly correlated. <h3>Conclusions</h3> Using validated metrics of acceptability, feasibility and appropriateness, the suitability of this assessment-intervention bundle was confirmed amongst the multidisciplinary team. The high degree of general acceptability was contributed to by the affective attitude of adoption, and by user & patient experience. Staff awareness of the burden and opportunity costs involved did not appear to be prohibitively negative.