Objective Of Project Research Articles

Assessing the influence of land use/land cover dynamics and climate change on water resources in Upper Blue Nile, Ethiopia

ABSTRACT This study evaluates the impact of climate and land use changes on the Lake Tana Basin's hydrology, using datasets on land use, weather patterns, topography, soil characteristics, and discharge. Future climate data were obtained from Global Climate Models (GCMs) from the Coupled Model Intercomparison Project Phase Five (CMIP5) and generated using the Weather Generator (LARS-WG) tool from the Long Ashton Research Station with five distinct GCMs. Land use changes were projected using the Markov chain model based on cellular automata (CA). The Soil and Water Assessment Tool (SWAT) model was used to assess changes in hydrological elements between reference and future periods, with calibration and validation ensured by the Integrated Parameter Estimation and Uncertainty Analysis Tool (IPEAT). Projections indicate a 4.9 °C increase in ensemble mean annual temperature and a 16% rise in precipitation by the end of the 21st century under Representative Concentration Pathway (RCP) 8.5. Additionally, average annual hydrological components, including water yield, soil water, percolation, lateral flow, runoff, and actual and potential evapotranspiration, are expected to increase due to combined climate and land use changes. Therefore, it is crucial to fully understand these cumulative impacts before formulating and implementing water resource management strategies in the basin.

Historical and Future Asymmetry of ENSO Teleconnections with Extremes

Abstract El Niño-Southern Oscillation (ENSO) is the dominant source of climate variability globally. Many of the most devastating impacts of ENSO are felt through extremes. Here we present and describe a spatially complete global synthesis of extreme temperature and precipitation relationships with ENSO. We also investigate how these relationships evolve under a future warming scenario under high greenhouse gas emissions using fourteen models from the Coupled Model Intercomparison Project Phase 6 (CMIP6) ensemble. Firstly, we demonstrate that models broadly capture observed ENSO teleconnections to means and extremes using the Twentieth Century Reanalysis version 3 (20CRv3). The models project that more regions will experience an amplification of the historical ENSO teleconnection with mean temperature and precipitation than a dampening under a high-emissions climate projection. The response of the ENSO teleconnection with extremes is very similar to the mean response, with even larger changes in some regions. Hence, regions that are predicted to experience an amplification of the ENSO teleconnection under future warming can also expect a comparable amplification in the intensity of extremes. Furthermore, models that suggest greater amplification of ENSO amplitude also tend to exhibit greater intensification of teleconnections. Future changes in regional climate variability may be better constrained if changes in ENSO itself are better understood.

Impact of projected climate variability on agricultural water demand of key crops in drought-prone central India region

ABSTRACT Water scarcity predominantly affects agriculture production. It is mandatory to save future water to prevent its shortage due to variations in climate. Variation in climate is a significant factor responsible for frequent droughts over the Bundelkhand region in central India. It is necessary to obtain early warning studies in this region to manage and arrange future agricultural water. Out of best Regional Climate Models (RCMs) under the Coordinated Regional Downscaling Experiment (CORDEX) and their driving Coupled Model Intercomparison Project Phase 5 (CMIP5), General Circulation Models (GCMs) for India, the most effective model has been found based on the observed multiscale data for the region. The daily projected data (2021–2100) of best GCM, Earth System Model, ESM-2M have been used to evaluate the future water requirements for major rabi and hot weather crops grown in the region. The climate change effect is seen in the majority, especially in the upper Bundelkhand part. Most of the crops will need more water than the present condition, especially from 2071 to 2100. The findings will also help researchers and policymakers to utilize the future projected data to propose suitable water management strategies for agriculture.

Observed and CMIP6-model-simulated organic aerosol response to drought in the contiguous United States during summertime

Abstract. Drought events have been linked with the enhancements of organic aerosols (OAs), but the mechanisms have not been comprehensively understood. This study investigates the relationships between the monthly standardized precipitation–evapotranspiration index (SPEI) and surface OA in the contiguous United States (CONUS) during the summertime from 1998 to 2018. OA under severe drought conditions shows a significant increase in mass concentrations across most of the CONUS relative to non-drought periods, with the Pacific Northwest (PNW) and Southeast United States (SEUS) experiencing the highest average enhancement of 1.79 µg m−3 (112 %) and 0.92 µg m−3 (33 %), respectively. In the SEUS, a linear regression approach between OA and sulfate was used to estimate the epoxydiol-derived secondary organic aerosol (IEPOX SOA), which is the primary driver of the OA enhancements under droughts due to the simultaneous increase in emissions of biogenic volatile organic compounds (VOCs; such as isoprene and monoterpene) and sulfate. The rise in sulfate is mainly caused by the reduced wet deposition because of the up to 62 % lower precipitation amount. In the PNW, OA enhancements are closely linked to intensified wildfire emissions, which raise OA mass concentrations to be 4–8 times higher relative to non-fire conditions. All 10 Earth system models participating in the sixth phase of the Coupled Model Intercomparison Project (CMIP6) can capture the slopes between SPEI and OA in the PNW, with CESM2-WACCM and GFDL-ESM4 performing the best and worst in predicting the OA enhancement under severe droughts. However, all models significantly underestimate the OA increase in the SEUS, with Nor-ESM2-LM and MIRCO6 showing relatively better performance. This study reveals the key drivers of the elevated OA levels under droughts in the CONUS and underscores the deficiencies of current climate models in their predictive capacity for assessing the impact of future droughts on air quality.

Monitoring of the radioactivity in the marine environment: a White Paper - Part I

Radioactivity in the marine environment, although present since the Earth’s formation, is comparatively understudied in contrast to aerial and terrestrial environments. A thorough examination of the radioactivity levels in aquatic environments can establish a robust foundation for comprehending various geochemical processes and phenomena within the water column and near the seabed, and as a result estimate the impact of radioactivity on local ecosystems. To achieve this objective, in-situ, long-term, and continuous monitoring is required. The present part I of the white paper highlights the fundamentals of marine radioactivity, describes the main objectives of an ambitious EU-funded project (RAMONES: Radioactivity Monitoring in Ocean Ecosystems) and introduces the innovative aspects of the technology developed as novel solutions to open problems.

Projected future changes in the cryosphere and hydrology of a mountainous catchment in the upper Heihe River, China

Abstract. Climate warming exacerbates the degradation of the mountain cryosphere, including glacier retreat, permafrost degradation, and snow cover reduction. These changes dramatically alter the local and downstream hydrological regime, posing significant threats to basin-scale water resource management and sustainable development. However, this issue is still not adequately addressed, particularly in mountainous catchments. We developed an integrated cryospheric–hydrologic model, the FLEX-Cryo model, to comprehensively consider glaciers, snow cover, and frozen soil and their dynamic impacts on hydrological processes. Taking the mountainous Hulu catchment located in the upper Heihe River of China as a case study, we utilized the state-of-the-art climate change projection data under two scenarios (SSP2-4.5 and SSP5-8.5) from the sixth phase of the Coupled Model Intercomparison Project (CMIP6) to simulate the future changes in the mountainous cryosphere and their impacts on hydrology. Our findings showed that under the medium-emission scenario (SSP2-4.5) and high-emission scenario (SSP5-8.5), by the end of the 21st century, the glacier will completely melt out around the years 2051 and 2045, respectively. The annual maximum snow water equivalent is projected to decrease by 41.4 % and 46.0 %, while the duration of snow cover will be reduced by approximately 45 and 70 d. The freeze onset of seasonally frozen soil is expected to be delayed by 10 and 22 d, while the thaw onset of permafrost is likely to advance by 19 and 32 d. Moreover, the maximum freeze depth of seasonally frozen soil is projected to decrease by 5.2 and 10.9 cm per decade, and the depth of the active layer will increase by 8.2 and 15.5 cm per decade. Regarding hydrology, catchment total runoff exhibits a decreasing trend, and the tipping point of glacier runoff occurs approximately between 2019 and 2021. Permafrost degradation will likely reduce the duration of low runoff in the early thawing season; the discontinuous baseflow recession gradually transitions into linear recessions, and the baseflow increases. Our results highlight the significant changes expected in the mountainous cryosphere and hydrology in the future. These findings enhance our understanding of cold-region hydrological processes and have the potential to assist local and downstream water resource management in addressing the challenges posed by climate change.

РЕЗУЛЬТАТЫ НАУЧНЫХ ЭКСПЕДИЦИОННЫХ ГЕОЛОГО-ГЕОФИЗИЧЕСКИХ ИССЛЕДОВАНИЙ ПОЛЕЗНЫХ ИСКОПАЕМЫХ МОРЕЙ ДАЛЬНЕВОСТОЧНОГО РЕГИОНА РОССИЙСКОЙ ФЕДЕРАЦИИ И ТИХОГО ОКЕАНА (ПРОЕКТ «ГЕОМИР»)

The paper presents a brief overview of the results of integrated geological, geophysical and oceanographic studies for the period 2017–2023, for which interregional generalizations were made on some promising areas of study of underwater mineral resources and the environment. The data on geological underwater objects, in particular, manganese ores of the Sea of Japan and the Sea of Okhotsk and adjacent water areas; rare-earth ores of the Tomtor ore cluster, ancient and modern coastal-marine placers of the Laptev Sea coast are presented; barite ore occurrences “Barite Hills” (in the Sea of Okhotsk); ferromanganese formations of the Eastern Arctic shelf of Russia; coastal marine placers of the shelf and coast of the Far Eastern seas, including gold-bearing placers. including gold-bearing placers of the shelf zone of the south of Primorye and north of Sakhalin, titanomagnetite placers of the Kuril Islands, gold-bearing placers of the North Sakhalin Plain and others. Direct signs of hydrocarbons were obtained in areas previously considered unpromising (including the South China Sea), gas hydrate accumulations were mapped and studied in the Sea of Okhotsk and the Sea of Japan, prospecting for gas hydrates in the Bering Sea was prepared, and comparative studies of hydrate-bearing capacity of the marginal seas of the NW Pacific and the Indian Ocean were carried out. The main features of the distribution of lithologic and gas-geochemical indicators of hydrocarbon gases in bottom sediments of the southwestern sector of the East Siberian Sea, which is the least studied in terms of oil and gas content, were studied. Based on the data of gas-geochemical studies, the prospects of oil and gas content of the eastern shelf of the Arctic were assessed. The results of geomicrobiological studies in the seas of the Far East region are described. In some cases deepsea sediments themselves (peloid-like sediments, etc.) appear to be a separate huge mineral resource. At present, the “continent-ocean” transition zone and neutral waters can become the most important source of replenishing the mineral resource base of these mineral components. The presented research corresponds to the main objectives of the GEOMIR project of the national action plan within the UN Decade of Ocean Sciences for Sustainable Development (2021–2030) and was carried out mainly in accordance with the directions of the state assignment. Studies of gas hydrates were carried out within the framework of the WESTPAC working group “Gas hydrates and methane fluxes in the Indo-Pacific region” (CoSGas, 2021–2024), established on the initiative and under the leadership of Russia.

Effects of climate warming on energetics and habitat of the world's largest marine ectotherm

Responses of organisms to climate warming are variable and complex. Effects on species distributions are already evident and mean global surface ocean temperatures are likely to warm by up to 4.1 °C by 2100, substantially impacting the physiology and distributions of ectotherms. The largest marine ectotherm, the whale shark Rhincodon typus, broadly prefers sea surface temperatures (SST) ranging from 23 to 30 °C. Whole-species distribution models have projected a poleward range shift under future scenarios of climate change, but these models do not consider intraspecific variation or phenotypic plasticity in thermal limits when modelling species responses, and the impact of climate warming on the energetic requirements of whale sharks is unknown. Using a dataset of 111 whale shark movement tracks from aggregation sites in five countries across the Indian Ocean and the latest Earth-system modelling produced from Coupled Model Intercomparison Project Phase 6 for the Intergovernmental Panel on Climate Change, we examined how SST and total zooplankton biomass, their main food source, may change in the future, and what this means for the energetic balance and extent of suitable habitat for whale sharks. Earth System Models, under three Shared Socioeconomic Pathways (SSPs; SSP1–2.6, SSP3–7.0 and SSP5–8.5), project that by 2100 mean SST in four regions where whale shark aggregations are found will increase by up to 4.9 °C relative to the present, while zooplankton biomass will decrease. This reduction in zooplankton is projected to be accompanied by an increase in the energetic requirements of whale sharks because warmer water temperatures will increase their metabolic rate. We found marked differences in projected changes in the extent of suitable habitat when comparing a whole-species distribution model to one including regional variation. This suggests that the conventional approach of combining data from different regions within a species' distribution could underestimate the amount of local adaptation in populations, although parameterising local models could also suffer from having insufficient data and lead to model mis-specification or highly uncertain estimates. Our study highlights the need for further research into whale shark thermal tolerances and energetics, the complexities involved in projecting species responses to climate change, and the potential importance of considering intraspecific variation when building species distribution models.

Storylines of summer Arctic climate change constrained by Barents–Kara seas and Arctic tropospheric warming for climate risk assessment

Abstract. While climate models broadly agree on the changes expected to occur over the Arctic with global warming on a pan-Arctic scale (i.e. polar amplification, sea ice loss, and increased precipitation), the magnitude and patterns of these changes at regional and local scales remain uncertain. This limits the usability of climate model projections for risk assessments and their impact on human activities or ecosystems (e.g. fires and permafrost thawing). Whereas any single or ensemble mean projection may be of limited use to stakeholders, recent studies have shown the value of the storyline approach in providing a comprehensive and tractable set of climate projections that can be used to evaluate changes in environmental or societal risks associated with global warming. Here, we apply the storyline approach to a large ensemble of the Coupled Model Intercomparison Project Phase 6 (CMIP6) models with the aim of distilling the wide spread in model predictions into four physically plausible outcomes of Arctic summertime climate change. This is made possible by leveraging strong covariability in the climate system associated with well-known but poorly constrained teleconnections and local processes; specifically, we find that differences in Barents–Kara sea warming and lower-tropospheric warming over polar regions among CMIP6 models explain most of the inter-model variability in pan-Arctic surface summer climate response to global warming. Based on this novel finding, we compare regional disparities in climate change across the four storylines. Our storyline analysis highlights the fact that for a given amount of global warming, certain climate risks can be intensified, while others may be lessened, relative to a “middle-of-the-road” ensemble mean projection. We find this to be particularly relevant when comparing climate change over terrestrial and marine areas of the Arctic which can show substantial differences in their sensitivity to global warming. We conclude by discussing the potential implications of our findings for modelling climate change impacts on ecosystems and human activities.

Potential Impacts of Future Climate Change on Super-Typhoons in the Western North Pacific: Cloud-Resolving Case Studies Using Pseudo-Global Warming Experiments

Potential impacts of projected long-term climate change toward the end of the 21st century on rainfall and peak intensity of six super-typhoons in the western North Pacific (WNP) are assessed using a cloud-resolving model (CRM) and the pseudo-global warming (PGW) method, under two representative concentration pathway (RCP) emission scenarios of RCP4.5 and RCP8.5. Linear long-term trends in June–October are calculated from 38 Coupled Model Intercomparison Project phase 5 (CMIP5) models from 1981–2000 to 2081–2100, with warmings of about 3 °C in sea surface temperature, 4 °C in air temperature in the lower troposphere, and increases of 20% in moisture in RCP8.5. The changes in RCP4.5 are about half the amounts. For each typhoon, three experiments are carried out: a control run (CTL) using analysis data as initial and boundary conditions (IC/BCs), and two future runs with the trend added to the IC/BCs, one for RCP4.5 and the other for RCP8.5, respectively. Their results are compared for potential impacts of climate change. In future scenarios, all six typhoons produce more rain rather consistently, by around 10% in RCP4.5 and 20% in RCP8.5 inside 200–250 km from the center, with increased variability toward larger radii. Such increases are tested to be highly significant and can be largely explained by the increased moisture and water vapor convergence in future scenarios. However, using this method, the results on peak intensity are mixed and inconsistent, with the majority of cases becoming somewhat weaker in future runs. It is believed that in the procedure to determine the best initial time for CTL, which yielded the strongest TC, often within a few hPa in minimum central sea-level pressure to the best track data, an advantage was introduced to the CTL unintentionally. Once the long-term trends were added in future runs, the environment of the storm was altered and became not as favorable for subsequent intensification. Thus, the PGW approach may have some bias in assessing the peak intensity of such super-typhoon cases, and caution should be practiced.

Simulating springtime extreme rainfall over Southern East Asia: unveiling the importance of synoptic-scale activities

This study investigates the influence of synoptic-scale activities on extreme precipitation during March–April–May (MAM) over Southern East Asia (SEA) using observational data and compares the results with the outputs from 20 Coupled Model Intercomparison Project phase 6 (CMIP6) historical runs. Observations show that SEA intense daily precipitation in MAM is linked to enhanced upper-level synoptic-scale waves; these disturbances are associated with significant anomalous temperature advection as well as moisture flux convergence, creating favorable conditions for extreme rainfall. Furthermore, it is found that a temperature advection index (TAI) can be utilized to characterize such synoptic-scale activities. Inspection of CMIP6 historical runs reveals that, among 20 models, 13 models perform well in accurately capturing the observed SEA rainfall pattern; such extreme events are also closely linked to TAI in the model environment. Overall, observed (simulated) results show that 78% (75%) of extreme events in the Yangtze River Basin–South Korea–south of Japan region can be attributed to positive TAI. Additionally, the related circulation anomalies such as the upper-level synoptic-scale wave feature, temperature advection, and moisture anomalies from these models closely resemble those observed during extreme precipitation days in SEA. Our findings suggest that TAI can effectively indicate both the frequency and intensity of extreme rainfall events in SEA, along with the associated synoptic-scale activities. Further study reveals a close lead-lag correlation between TAI and rainfall patterns over SEA. This correlation is characterized by eastward-propagating wave trains across the entire troposphere. Consequently, TAI not only acts as a benchmark for quantifying synoptic-scale extreme rainfall in SEA but also shows potential in predicting SEA rainfall linked to synoptic-scale disturbances.

Artificial intelligence investments reduce risks to critical mineral supply

This paper employs insights from earth science on the financial risk of project developments to present an economic theory of critical minerals. Our theory posits that back-ended critical mineral projects that have unaddressed technical and non-technical barriers, such as those involving lithium and cobalt, exhibit an additional risk for investors which we term the “back-ended risk premium”. We show that the back-ended risk premium increases the cost of capital and, therefore, has the potential to reduce investment in the sector. We posit that the back-ended risk premium may also reduce the gains in productivity expected from artificial intelligence (AI) technologies in the mining sector. Progress in AI may, however, lessen the back-ended risk premium itself by shortening the duration of mining projects and the required rate of investment by reducing the associated risk. We conclude that the best way to reduce the costs associated with energy transition is for governments to invest heavily in AI mining technologies and research.

The Ouest Data Hub: An Interregional Health Data Sharing Ecosystem for Research.

The Ouest Data Hub (ODH) a project lead by GCS HUGO which is a cooperation group of University Hospitals in the French Grand Ouest region represents a groundbreaking initiative in this territory, advancing health data sharing and reuse to support research driven by real-world health data. Central to its structure are the Clinical Data Warehouses (CDWs) and Clinical Data Centers (CDCs), essential for analytics and as the linchpin of the ODH's status as an interregional Learning Health System. Aimed at fostering innovation and research, the ODH's collaborative and multi-institutional model effectively utilizes both local and shared resources. Yet, the path is not without challenges, especially in data quality and interoperability, where ongoing harmonization and standard adherence are critical. In 2023, this facilitated access to extensive health data from over 9.3 million patient records, demonstrating the ODH's capacity for both monocentric and multicentric research across various clinical fields, in close collaboration with physicians. The integration of healthcare professionals is crucial, ensuring data's clinical relevance and guiding accurate interpretations. Future expansions of the ODH to new hospitals and data types promise to enhance its model further, already inspiring similar frameworks across France. This scalable model for health data ecosystems showcases the ODH's potential as a foundation for national and supranational data sharing efforts.

Continuing Educational Program in Nursing Informatics for Greek Nurses.

Nurses are required to adapt to a complex and rapidly evolving environment that incorporates new IT technologies. Continuing, lifelong learning, especially in the fast-growing fields of Nursing Informatics, eHealth and related Information and Communication Technologies, is vital to the professionalism of nurses. The study presents the curriculum development and implementation of the educational project entitled "Training of Nurses in Nursing Informatics and Information and Communication Technologies (ICT)" which has been designed and offered to Greek nurses as a continuing - lifelong online educational program by the Health Informatics Laboratory of the National and Kapodistrian University of Athens. The training material was created in three modules and 29 sub-modules, considering the new advancements and recommended competencies, necessary for the nurse, in the fields of Nursing Informatics and ICT. So far, eight training cycle courses have been offered to 1388 nurses, free of charge. Each course integrates synchronous and asynchronous distance learning methods and requires a workload of 70 hours over 10 weeks. The initial evaluation of the course by the participants, concerning its effectiveness, usefulness, and innovation are very encouraging.

Empowering Indonesian Women Migrant Workers in Singapore: the Role of Conflict Management Training and Personality-Based Communication for Migrant Workers Community

The present study focuses on a community service project designed to evaluate the efficacy of conflict management training and personality-based communication strategies on Indonesian female migrant workers in Singapore, who are also students at the Open University of Indonesia. The project's primary objective was to aid participants in comprehending themselves and their coworkers more effectively, and to develop practical skills for resolving conflicts and communicating effectively in diverse work environments. Conflict management training encompasses case studies, role-playing, and group discussions, enabling participants to acquire knowledge regarding different conflict management styles and effective communication techniques based on personality types. The post-training evaluation revealed a significant improvement in the participants' comprehension of personality types and their capacity to manage conflicts. This study highlights the significance of incorporating personality aspects into conflict management and communication training, and the advantages of such training in enhancing interpersonal relationships and productivity in the workplace, as well as managing conflicts between individuals and organisations.

Socio-Digital Co-Design Practices

Studies of architectural design practices have shown that building projects take shape through the intricate interactions between human designers and various technological tools. In present-day’s architectural practice, these interactions are increasingly being reconfigured by two major trends that are affecting the future of construction: digitalisation and the imperative to make building processes and the built environment sustainable. Against this backdrop, the paper presents insights from an ethnographic case study on socio-digital co-design practices in the planning and preconstruction phase of an ambitious building project. This research explores how digital tools reconfigure design practices and highlights the ‘reverse salient’ that has limited the realisation of the integrative potential of socio-digital design processes. Using a practice theory approach centred on ‘socio-digital co-design’, the study shows that digital tools reorganise, but do not take over, the coordination practices in early design necessary to achieve coherent results and sustainability outcomes.

Senecio inaequidens DC. will thrive in future climate: A case study in a Mediterranean biodiversity hotspot

Monitoring the expansion of invasive non-native plants under current and future climatic conditions is crucial for understanding biodiversity threats, addressing the ecological impact, and developing effective management strategies. This study focuses on modelling the expansion and distribution of Senecio inaequidens DC. on the island of Sardinia (Italy) to address these environmental challenges. The objectives were to identify bio-climatically suitable areas under current conditions, project potential future distribution, and evaluate invasion dynamics on the island to localize suitable areas for effective management strategies.Species data were collected from 1991 to the present, supplemented by global databases and analyzed using an ensemble species distribution model approach. This approach utilized presence data, high-resolution current bioclimatic variables (40 m2), developed explicitly for our study area, and two future scenarios derived from the newly Coupled Model Intercomparison Project Phase 6 (CMIP6) under Shared Socio-economic Pathways (SSP2–4.5 and SSP5–8.5 for 2040 and 2060).The ensemble model's findings suggest a close alignment between the currently documented occurrences of S. inaequidens and its bio-climatically suitable habitats in Sardinia. Moreover, predictions indicate high bioclimatic suitability for S. inaequidens in the western and southwestern coastal regions, contrasting with its known occurrences at higher altitudes. Notably, the model also forecasts high bio-climatic suitability across most small islands surrounding the region and in central-east Sardinia, potentially indicating habitats at lower altitudes compared to current records.Under the SSP2–4.5 scenario, suitable areas are expected to nearly double by 2040 and more than double by 2060, compared to current conditions. Under the SSP5–8.5 scenario, the increase in suitable habitats is projected to be about 83.31% by 2040 and more than double by 2060. These results highlight the species' ability to thrive under climate change, with a more pronounced range expansion under the pessimistic management regime (SSP5–8.5) than under the intermediate one (SSP2–4.5), particularly in the central region of the island. This expansion under the more severe management scenario is particularly alarming as it reflects limited implementation of environmental management policies.The study underscores the potential ecological risk posed by S. inaequidens due to its potential range expansion and ability to invade different habitat types, from coastal regions to mountainous areas, under current and future scenarios. Based on these findings, we propose targeted management actions for monitoring and eradicating the species, leveraging prior information and local experiences to mitigate its impact.

Barriers and facilitators to implement the redispensing of unused oral anticancer drugs in clinical care: A hybrid-effectiveness type I study

BackgroundMinimizing medication waste through the redispensing of oral anticancer drugs (OADs) that were unused by patients provides economic and environmental benefits, but this is not yet universally implemented in clinical care. Objective(S)To identify barriers and facilitators to the implementation of redispensing unused OADs in clinical care. MethodsA multicentre intervention study following a hybrid effectiveness-implementation type I design was conducted, consisting of semi-structured interviews with key stakeholders involved in the redispensing program: pharmacy employees, prescribing clinicians in oncology and haematology, patients who participated in redispensing and patients who declined trial participation. Questions encompassed experiences and suggestions for future implementation. The Consolidated Framework for Implementation Research (CFIR) guided data collection and categorisation of identified barriers and facilitators through thematic analysis. ResultsIn total, 35 interviews were conducted, identifying 15 themes encompassing barriers and facilitators, reflecting all CFIR domains. Facilitators encompassed: 1) convenient process requiring an acceptable time-investment; 2) support from project leaders and implementation champions; 3) being well-motivated by personal values and societal impact; 4) feeling ensured of medication quality upon redispensing; 5) endorsement by healthcare providers for patient participation; 6) clear and personal patient communication; 7) good visibility of intervention successes; and 8) implementation well supported through a collaborative network. Barriers encompassed: 1) unclear target population; 2) redispensing legally prohibited; 3) absence of financial compensation for pharmacies; 4) complexity arising from two parallel work processes; 5) widespread communication on adjustments within local teams challenging; 6) patient's low receptiveness due to burden of oncology treatment; and 7) lack of familiarization among pharmacy technicians. ConclusionsFacilitators for implementation of redispensing unused drugs mainly related to people's values, motivation, and societal demand, whereas barriers mainly encompassed practical issues, including knowledge, time, financial resources, and legal conditions. Strategies emphasizing the benefits of redispensing and further streamlining process compatibility could support implementation.

Development and psychometric validation of a patient safety assessment tool in German Radiation Oncology: the PaSaGeRO Study protocol

IntroductionEnsuring patient safety in radiation oncology is crucial for delivering high-quality healthcare. Patient safety indicators (PSIs) provide a mechanism for identifying, quantifying and evaluating risks and the effectiveness of safety...

Barriers and facilitators of cardiovascular disease prevention services for women with prior gestational diabetes or hypertensive disorders of pregnancy in low-income, middle-income and high-income settings: a scoping review protocol

IntroductionWomen with previous pregnancy-related cardiovascular risk indicators, including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP), have an increased risk of future cardiovascular disease (CVD). Although CVD screening...