ContextPrevious studies have shown that steered training data or dataset selection can lead to better performance for cross project defect prediction(CPDP). On the other hand, feature selection and data quality are issues to consider in CPDP. ObjectiveWe aim at utilizing the Nearest Neighbor (NN)-Filter, embedded in genetic algorithm to produce validation sets for generating evolving training datasets to tackle CPDP while accounting for potential noise in defect labels. We also investigate the impact of using different feature sets. MethodWe extend our proposed approach, Genetic Instance Selection (GIS), by incorporating feature selection in its setting. We use 41 releases of 11 multi-version projects to assess the performance GIS in comparison with benchmark CPDP (NN-filter and Naive-CPDP) and within project (Cross-Validation(CV) and Previous Releases(PR)). To assess the impact of feature sets, we use two sets of features, SCM+OO+LOC(all) and CK+LOC(ckloc) as well as iterative info-gain subsetting(IG) for feature selection. ResultsGIS variant with info gain feature selection is significantly better than NN-Filter (all,ckloc,IG) in terms of F1 (p=values≪0.001, Cohen’s d={0.621,0.845,0.762}) and G (p=values≪0.001, Cohen’s d={0.899,1.114,1.056}), and Naive CPDP (all,ckloc,IG) in terms of F1 (p=values≪0.001, Cohen’s d={0.743,0.865,0.789}) and G (p=values≪0.001, Cohen’s d={1.027,1.119,1.050}). Overall, the performance of GIS is comparable to that of within project defect prediction (WPDP) benchmarks, i.e. CV and PR. In terms of multiple comparisons test, all variants of GIS belong to the top ranking group of approaches. ConclusionsWe conclude that datasets obtained from search based approaches combined with feature selection techniques is a promising way to tackle CPDP. Especially, the performance comparison with the within project scenario encourages further investigation of our approach. However, the performance of GIS is based on high recall in the expense of a loss in precision. Using different optimization goals, utilizing other validation datasets and other feature selection techniques are possible future directions to investigate.