Abstract Drawing from the theoretical model—the Micro-Meso-Macro Framework— we elucidate factors that facilitated or impeded diverse sample recruitment to a community-based caregiver intervention study with high Hispanic/Latino representation in California. Based on our multi-level analysis of recruitment meetings and community outreach tracking, we documented the following factors implicated in trial participation: 1) Micro: prior encounters with the research enterprise; educational attainment and occupational status; sense of altruism and beneficence; monetary incentivization; comfort with disclosure of private matters; starting from ground zero; gender issues; and 2) Meso/macro: assembling a proactive scientific team; incorporating a marketing perspective; leveraging logos and reputation; training trial staff and community partners; writing project budgets that incentivize diverse trial recruitment; making inroads with community partners; navigating technological challenges; and tapping into resources to alleviate barriers. Latinos were adversely affected by low exposure to research activities and technological barriers which necessitated extra supports during trial participation.
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