Growth Progression Research Articles

The Effect Of Facilities And Prices On Parents' Decisions To Send Children To School And Brand Image As Intervening Variables At Tabqha Christian Elementary School Batam

Schools have a role in providing a foundation for the growth and development of students' progress. The selection of a quality school is one of the keys to obtaining children's success according to parents' expectations. Parents' decisions to choose a school usually consider price, facilities and a positive image of the school. The purpose of this study was to analyze the effect of facilities and prices on parents' decisions to send their children to school and brand image as an intervening variable at Tabqha Christian Elementary School Batam. The population in this study were parents of grade I elementary school students with a sample of 62 respondents. The technique used is saturated sampling technique and the significance test uses the sobel test. The results of direct influence research show that; Facilities have a positive and significant effect on brand image, Price has no significant effect on brand image, Facilities have no significant effect on parents' decisions, Price has a positive and significant effect on parents' decisions, and Brand image has a positive and significant effect on parents' decisions. While the indirect effect results in that facilities have a positive and significant effect on parental decisions through brand image and price has no significant effect on parental decisions through brand image.

Silmitasertib in Combination With Cabozantinib Impairs Liver Cancer Cell Cycle Progression, Induces Apoptosis, and Delays Tumor Growth in a Preclinical Model.

The rising incidence of hepatocellular carcinoma (HCC) is a global problem. Several approved treatments, including immune therapy and multi-tyrosine kinase inhibitors, are used for treatment, although the results are not optimum. There is an unmet need to develop highly effective chemotherapies for HCC. Targeting multiple pathways to attack cancer cells is beneficial. Cabozantinib is an orally available bioactive multikinase inhibitor and has a modest effect on HCC treatment. Silmitasertib is an orally bioavailable, potent CK2 inhibitor with a direct role in DNA damage repair and is in clinical trials for other cancers. In this study, we planned to repurpose these existing drugs on HCC treatment. We observed a stronger antiproliferative effect of these two combined drugs on HCC cells generated from different etiologies as compared to the single treatment. Global RNA-seq analyses revealed a decrease in the expression of G2/M cell cycle transition genes in HCC cells following combination treatment, suggesting G2 phase cell arrest. We observed G2/M cell cycle phase arrest in HCC cells upon combination treatment compared to the single-treated or vehicle-treated control cells. The downregulation of CCNA2 and CDC25C following combination therapy further supported the observation. Subsequent analyses demonstrated that combination treatment inhibited 70 kDa ribosomal protein S6 kinase (p70S6K) phosphorylation, and increased Bim expression. Apoptosis of HCC cells were accompanied by increased poly (ADP-ribose) polymerase cleavage and caspase-9 activation. Next, we observed that a combination therapy significantly delayed the progression of HCC xenograft growth as compared to vehicle control. Together, our results suggested combining cabozantinib and silmitasertib would be a promising treatment option for HCC.

MFGE8 promotes gastric cancer progression by activating the IL-6/JAK/STAT3 signaling

ObjectiveGastric cancer is malignant cancer with high morbidity and mortality worldwide. Milk fat globule EGF and factor V/VIII domain containing (MFGE8) was involved in many cancers. Nevertheless, the role of MFGE8 in gastric cancer remained indistinct. To probe the role of MFGE8 in gastric cancer and further explore the regulating mechanism. MethodsGEPIA was employed for analysis of MFGE8 expression and survival of gastric cancer patients. MFGE8 expression in gastric cancer was determined by immunohistochemistry, PCR, and western blot. The effect of MFGE8 on gastric cancer cells were evaluated by a series of cell function experiments. The mechanism of MFGE8 on gastric cancer was analyzed by GSEA and verified by in vitro and in vivo experiments. ResultsMFGE8 was over-expressed in gastric cancer. Silence of MFGE8 suppressed cell viability, proliferated ability, migrated and invasive ability, and EMT, but accelerated cell apoptosis. The opposite results were obtained in MFGE8-overexpressed gastric cancer cells. Zinc finger and BTB domain containing 7 A (ZBTB7A) was a transcription factor of MFGE8. ZBTB7A overexpression eliminated the effect of MFGE8 on gastric cancer cells. MFGE8 activated the IL-6/JAK/STAT3 signaling. Inhibition of IL-6/JAK/STAT3 signaling by Stattic (pathway inhibitor) could eliminate the promoting effect of MFGE8 on IL-6/JAK/STAT3 signaling. In addition, MFGE8 shRNA inhibited tumor growth. ConclusionMFGE8 promoted cell proliferation, EMT progress, and tumor growth of gastric cancer by activating the IL-6/JAK/STAT3 signaling.

From waste to wonder: Developing engineered nanomaterials for multifaceted applications

The escalating generation of industrial and consumer waste poses a significant environmental challenge, necessitating innovative approaches to waste management and resource utilization. One promising solution lies in the transformation of waste materials into engineered nanomaterials (ENMs), which hold immense potential for a diverse range of applications. This review explores the development of ENMs from waste, highlighting their multifaceted uses in environmental remediation, energy storage, medical applications, and advanced manufacturing. The process of converting waste into ENMs involves sophisticated techniques such as chemical vapour deposition, sol-gel synthesis, and hydrothermal methods, which enable the creation of materials with precise structural and functional properties at the nanoscale. By utilizing waste as a raw material, this approach not only addresses waste disposal issues but also provides a sustainable and cost-effective source of high-value nanomaterials. ENMs derived from waste exhibit unique properties, including high surface area, tunable porosity, and enhanced reactivity, making them suitable for environmental applications such as pollutant adsorption, water purification, and air filtration. In the energy sector, these nanomaterials contribute to the development of advanced batteries, supercapacitors, and fuel cells, enhancing energy storage and conversion efficiency. The biomedical field benefits from waste-derived ENMs through their application in drug delivery systems, diagnostic tools, and tissue engineering. The biocompatibility and functional versatility of these materials enable targeted therapeutic interventions and innovative medical solutions. Furthermore, in advanced manufacturing, ENMs improve the performance and durability of materials used in electronics, coatings, and composites, fostering the development of next-generation products with superior properties. The integration of waste-derived ENMs into various industries represents a paradigm shift towards a circular economy, where waste is not merely a byproduct but a valuable resource. This approach aligns with global sustainability goals, promoting resource efficiency, reducing environmental impact, and driving technological advancements. In conclusion, the development of engineered nanomaterials from waste exemplifies the transformative potential of nanotechnology in addressing critical environmental and industrial challenges. By harnessing waste as a resource, this innovative approach paves the way for multifaceted applications that contribute to environmental sustainability, technological progress, and economic growth. Further research and development in this field will continue to expand the possibilities and impact of waste-derived ENMs in various sectors.

Assessing Southeast Asia countries’ potential in the semiconductor supply chain: an objectively weighting multi-criteria decision-making approach

The semiconductor industry serves as a key enabler of technological progress and economic growth on a global scale. With Southeast Asia emerging as a region of increasing importance in the global supply chain landscape, understanding the potential for its countries to participate in the semiconductor supply chain becomes crucial. Despite extensive research on global supply chain dynamics, a focused analysis on the role of Southeast Asia within this crucial industry has been notably absent, particularly considering recent geopolitical and economic shifts. This gap has been filled by employing a rigorously designed Multi-Criteria Decision Making (MCDM) approach that integrates the Criteria Importance Through Intercriteria Correlation (CRITIC) method and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). Data on fifteen indicators, including economic stability, technological innovation capacity, and infrastructural capabilities, were collected and identified through an extensive literature review and consultations with stakeholders. These indicators were weighted using the CRITIC method to reflect their relative importance, and each country’s position relative to an ideal solution was assessed using the TOPSIS method. It was revealed that countries such as Singapore and Malaysia possess significant potential due to their advanced technological infrastructure and stable economic environments. Other countries, like Vietnam and Indonesia, were also found to exhibit promising capabilities, albeit with certain limitations. The study highlights the varying strengths and strategic areas that should be considered by policymakers and investors to enhance integration into the global semiconductor supply chain. Significant contributions to the strategic decision-making process have been made by providing a nuanced analysis of the region’s readiness and identifying specific areas for investment and policy intervention. By offering a methodological framework that can be adapted to other regions and sectors, not only has an existing research void been filled, but the practical understanding of effectively leveraging Southeast Asia’s potential in the semiconductor industry has also been enhanced.

A novel EZH1/2 dual inhibitor inhibits GCB DLBCL through cell cycle regulation and M2 tumor-associated macrophage polarization

The incidence of germinal center B-cell-like type diffuse large B-cell lymphoma (GCB DLBCL) is steadily increasing, with a known hereditary component. Although some molecular mechanisms in GCB DLBCL have been elucidated, understanding remains incomplete, limiting the effectiveness of targeted therapies. In GCB DLBCL patients, abnormally high expression of zeste homologs 2 (EZH2) is noted, and the compensatory effect of EZH1 following EZH2 inhibition contributes to poor prognosis. This highlights the potential of dual targeting of EZH1/2 as a promising strategy. In this study, we developed a novel inhibitor, EZH-1-P2, targeting EZH1/2, and evaluated its anti-tumor effects on DLBCL cells. Mechanistically, inhibition of EZH1/2 affects the epigenetic regulation of gene expression related to p53, impacting cell cycle progression and GCB DLBCL cell growth. Additionally, while EZH1/2 inhibition impacts NOTCH signaling, the precise mechanism by which it affects M2-type tumor-associated macrophage (M2-TAM) polarization and germinal center expansion requires further investigation. Our research introduces EZH-1-P2 as a novel inhibitor with potential as a candidate for GCB DLBCL therapy, although further studies are needed to fully elucidate its mechanisms.

Does intellectual property rights protection help reduce carbon emissions?

Our study examines the relationship between intellectual property rights protection (IPRP) and carbon emissions (CE) using an unbalanced panel data set from 116 countries spanning 2008–2020. The analysis reveals a positive relationship between IPRP and CE. Mechanism tests and nonlinear analysis further elucidate this relationship. The mediation effect results indicated that IPRP indirectly fostered CE growth by inhibiting energy structure’s improvement, demonstrating that IPRP exacerbated the dependence on traditional high-carbon energy sources, hindering the transition to cleaner, more efficient energy systems. The analysis also revealed that IPRP indirectly promoted the increase of CE by promoting technological progress and economic growth. The moderation effect results suggest that political stability could mitigate the positive impact of IPRP on CE. Furthermore, the analysis reveals an inverted U-shaped relationship between IPRP and CE, indicating that while IPRP promotes an increase in CE in the initial stages, its intensification suppresses CE growth beyond a turning point. Hence, our study provides new theoretical and empirical evidence to understand the complex relationship between IPRP and CE. It also offers policy recommendations for effectively integrating global carbon reduction efforts with intellectual property policies.

Analysis of Green Intellectual Property Issues and Countermeasures from the Perspective of International Law

As an advanced form of productivity driven by green technological innovation, there exists a natural fit and close connection between new quality productivity and green intellectual property rights. Legal protection is the cornerstone of the development of new productivity, in which the comprehensive protection of intellectual property rights is particularly crucial: green intellectual property rights, as a key force to adhere to sustainable development and promote scientific and technological progress and economic growth, has a central role to play in incentivizing environmental protection as the core of independent innovation, thus becoming an indispensable institutional guarantee for the development of new productivity. This institutional guarantee ensures the legitimate rights and interests of innovation achievements, and is a powerful driving force and a long-term solution for the continuous progress of productive forces. At present, the field of intellectual property cooperation is encountering diversified challenges and problems: the unilateralization caused by some developed countries, the rigidity of international rules on intellectual property, the stagnation behind the digital age, and the imbalance in the distribution of existing international benefits of intellectual property, which should be paid close attention to. In order to effectively promote green technological innovation and escort the green intellectual property protection system to a stable and far-reaching future, countries and enterprises should face the current challenges rationally, correctly understand the differences and conflicts between green intellectual property rights and ordinary intellectual property rights, gain a deeper understanding of the existing relevant international law foundations, and promptly solve the green intellectual property rights issues, improve the relevant international conventions and treaties, strengthen the coordination and cooperation of international organizations, and establish a fair and reasonable green technology patent protection mechanism. fair and reasonable patent protection mechanism for green technology. Only when countries join hands to improve the green intellectual property protection mechanism, jointly combat transnational infringement and maintain a fair market competition environment can the legitimate rights and interests of innovators be safeguarded.

European integration and economic growth in emerging Europe: the role of institutions and policy factors

ABSTRACT The purpose of this study is to contribute to an investigation of the role of European integration as a potential growth driver or convergence engine for emerging Europe. We classify emerging Europe into two groups of economies: (1) 11 new EU member states from Central and Eastern Europe; and (2) six EU candidate countries from the Western Balkans. Our results are also highly relevant for the so-called ‘association trio’ within the EU’s framework of Eastern partnership. The more specific research objectives are to explore (1) what the main driving forces behind growth dynamics in post-communist economies in Europe are; and (2) whether the experience of fast-reforming new EU member states can be replicated or adapted to the EU candidate countries. We provide evidence that the process of European integration holds strong transformative power to accelerate institutional progress and support economic growth.

Achieving and Sustaining the Green Economy and It Potential Benefit to the Economic Growth of Sierra Leone: Empirical Analysis

The study examines the possible advantages of establishing and maintaining a green economy in Sierra Leone, focusing on social progress, environmental sustainability, and economic growth. The research aims to provide a scientifically grounded and research-based understanding of the process of transitioning to a green economy and its effects on Sierra Leone's economic development by examining important sectors like aquaculture, fisheries, and agriculture. This empirical study looks at the relationship between fishing, aquaculture, and agriculture and Sierra Leone's economic growth from 1990 to 2018 using regression models and statistical analyses. The study looks at the relationships between green economic practices and economic growth using a number of techniques, including correlation, Granger causality, and unit root tests. According to the findings, Sierra Leone urgently needs a green economy because of its vulnerability to environmental degradation, climate change shocks, and macroeconomics issues. The study accentuates the possible advantages of agriculture, fishing, and aquaculture for economic expansion and upswing. It also emphasizes how important it is to adopt sustainable practices and green technologies to reduce the risks associated with climate change. The recognition of the links between green economic principles and Sierra Leone's economic growth has increased as a result of this study. To facilitate the shift to a green economy, the study suggests implementing economic and fiscal policy tools, stepping up current initiatives, and enforcing regulations. In addition, building a supportive investment climate, encouraging stakeholder engagement, and fostering institutional collaboration are essential to establishing and maintaining a green economy in Sierra Leone. The analysis examines the potential advantages of establishing and maintaining a green economy in Sierra Leone, focusing on social progress, environmental sustainability, and economic growth.

ANALYSIS OF ENTREPRENEURIAL COMPETENCE ON BUSINESS PERFORMANCE IN MSMES KAHUT SIGERBORI ECOPRINT BANDAR LAMPUNG

The purpose of this paper is to assess entrepreneurial competence and business performance in micro, small and medium enterprises (MSMEs) Kahut Sigerbori Ecoprint in Bandar Lampung, as well as to test the impact of entrepreneurial competence on business performance. This writing uses qualitative writing design, uses a descriptive approach and uses observation and interview methodologies. This writing uses data processing methodologies such as data collection, data reduction, data presentation, and conclusions. The writing population is 9 workers and 1 owner of Kahut Sigerbori Ecoprint Bandar Lampung. An interview was conducted with one of the individuals who served as the owner of an MSME. Research findings show that entrepreneurial competence plays an important role in managing and improving company performance in MSMEs Kahut Sigerbori Ecoprint. The business performance of MSMEs Kahut Sigerbori Ecoprint has shown remarkable progress, with significant and substantial revenue growth. There is a direct correlation between entrepreneurial ability and business performance. MSMEs Kahut Sigerbori MSMEs Ecoprint.

Sugarcane sustainability in a changing climate: a systematic review on pests, diseases, and adaptive strategies

The cultivation of sugarcane (Saccharum officinarum L.) in the face of climate change requires robust strategies for managing pests, diseases, and weeds. This systematic review exposes critical deficiencies in current practices and underscores the need for climate-adaptive strategies. Climate change differentially influences pest behaviour, disease progression, and weed growth across various regions, yet the lack of region-specific responses impairs effective management. The review emphasizes the necessity for localized approaches that consider specific climatic conditions and the development of predictive models to anticipate pest and disease outbreaks. These models include Decision Support Systems (DSS), Support Vector Machines (SVM), Susceptible-Exposed-Infectious-Recovered (SEIR) models, Geographic Information Systems (GIS), Species Distribution Models (SDMs), Agricultural Production Systems sIMulator (APSIM), and Integrated Pest Management (IPM). Crucial strategies encompass integrated pest and disease management, adaptive breeding, precision agriculture, and ongoing innovation. Precision agriculture technologies, such as remote sensing and drones, enable early detection and prompt interventions. By adopting these adaptive measures and addressing existing research gaps, the sugarcane industry can bolster its resilience and maintain productivity amidst evolving climatic conditions.Systematic review registrationhttps://www.bmj.com/content/372/bmj.n71.

The contribution of technological innovation, trade and economic development to renewable energy use in the United Kingdom, Germany and Turkey

AbstractThis paper examines the causal impact of the technological innovation, trade openness and economic growth on the renewable energy use (RE) in Germany, the United Kingdom and Turkey. To this end, Breitung and Candelon (Journal of Econometrics, 2006, 132, 363) causality test linked to Toda and Yamamoto (Journal of Econometrics, 1995, 66, 225) procedure is applied on data for the period 1985–2021. Our results indicate that the German RE is mainly affected by the technological innovation and economic growth, but over the long‐term. Regarding the United Kingdom, its RE dynamics is found to be significantly impacted by the technological progress, trade openness and output growth all together, but only during the long‐run. However, in Turkey, the RE long‐term pattern is mainly led by the technological innovation, while the RE short‐term dynamics is primarily drown by the trade openness. This study provides policymakers a better understanding of RE pattern to formulate appropriate policies dealing with energy security, sustainable development and environmental pollution.

Legal concept of “intellectual property”: Theoretical issues

Based on the provisions of international legal acts and norms of national legislation, the authors analyze the definition of the concept of “intellectual property”. The conceptual approaches of some Russian researchers to the understanding of this definition are considered. It is revealed that the modern content of the term “intellectual property” raises questions, and the attitude to it on the part of representatives of the scientific community is seen ambiguous. The institute of intellectual property has overcome a huge historical path. In turn, today its structure is generally logical and open to the changes occurring in society, unified in accordance with the main provisions of existing international treaties. At the same time, the institute of intellectual property develops with the growth of scientific and technological progress of this or that society, as well as the system of integrative ties between interested countries, which means that research in this area should and will continue.

Evaluation and Prediction of Carbon Storage in the Qinghai-Tibet Plateau by Coupling the GMMOP and PLUS Models

Land-use alterations exert a profound impact on carbon storage within terrestrial ecosystems. Exploring the spatiotemporal dynamics of regional land use and carbon storage is crucial for optimizing national spatial planning and fostering low-carbon development. For this study, we utilized land-use data spanning from 2000 to 2020 for the Tibetan Plateau and assessed the spatial and temporal variations in carbon storage using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model. We adjusted the carbon density within the provinces in the study area as a prerequisite. Moreover, we integrated the Grey Multi-objective Decision-making (GMMOP) model with the Patch-generating Land-use Simulation (PLUS) model to forecast carbon storage alterations in 2030 across various scenarios. The findings indicated that between 2000 and 2020, the overall carbon storage witnessed a decrease of 18.94 × 108 t. Carbon storage in grassland decreased by 22.10 × 108 t, and carbon storage in unused land, forest land, cultivated land, construction land, and water increased by 1.56 × 108 t, 0.92 × 108 t, 0.66 × 108 t, 158.50 × 104 t and 26.74 × 104 t, respectively. The soil organic carbon pool exhibited the highest average carbon storage of 195.63 × 108 t, whereas the litterfall organic carbon pool contained the lowest average carbon stock of 15.07 × 108 t. In comparison with the levels observed in 2020, the total carbon storage experienced a reduction of 8.66 × 108 t and 5.29 × 108 t under the inherent progression and economic growth scenarios, respectively. Conversely, it rose by 11.87 × 108 t and 16.21 × 108 t under the environmental preservation and holistic progression scenarios, respectively. Under the holistic progression scenario, the belowground biomass organic carbon pool exhibited the highest carbon storage increase of 5.59%. These findings offer valuable insights for the management and enhancement of carbon sinks in the Qinghai-Tibet Plateau.

CDKL3 is a targetable regulator of cell cycle progression in cancers.

Cell cycle regulation is largely abnormal in cancers. Molecular understanding and therapeutic targeting of the aberrant cell cycle are essential. Here, we identified that an underappreciated serine/threonine kinase, cyclin-dependent kinase-like 3 (CDKL3), crucially drives rapid cell cycle progression and cell growth in cancers. With regard to mechanism, CDKL3 localizes in the nucleus and associates with specific cyclin to directly phosphorylate retinoblastoma (Rb) for quiescence exit. In parallel, CDKL3 prevents the ubiquitin-proteasomal degradation of cyclin-dependent kinase 4 (CDK4) by direct phosphorylation on T172 to sustain G1 phase advancement. The crucial function of CDKL3 in cancers was demonstrated both in vitro and in vivo. We also designed, synthesized, and characterized a first-in-class CDKL3-specific inhibitor, HZ1. HZ1 exhibits greater potency than CDK4/6 inhibitor in pan-cancer treatment by causing cell cycle arrest and overcomes acquired resistance to CDK4/6 inhibitor. In particular, CDKL3 has significant clinical relevance in colon cancer, and the effectiveness of HZ1 was demonstrated by murine and patient-derived cancer models. Collectively, this work presents an integrated paradigm of cancer cell cycle regulation and suggests CDKL3 targeting as a feasible approach in cancer treatment.

A data-driven optimization model for renewable electricity supply chain design

The rising electricity demand, driven by technological progress and population growth, has made the design of the electricity supply chain a major challenge. The transition to renewable energy sources has led to a substantial reduction in the costs and greenhouse gases emissions of electricity production. This study proposes a hybrid approach consisting of a recurrent neural network and an optimization model for designing a resilient electricity supply chain based on wind and solar energies. First, the electricity demand is forecast using the long short-term memory algorithm. Second, based on the forecast demand, a two-stage stochastic programming model is developed for designing an electricity supply chain under disruption risks. Partial and complete disruptions in power lines and facilities, including power plants, distribution and subtransmission substations, and low-power solar panel farms are considered. The objective of the proposed model is to minimize the total cost of the supply chain by making optimal decisions on facility location; technology selection for power plants; setting up transmission lines; and the quantity of power generation, power transmission, and power shortage in low- and high-voltage energy consumption systems. Three strategies are adopted to enhance the supply chain's resilience: multiple renewable energy sources, multiple power transmission lines, and lateral power lines. Lastly, the Sistan and Baluchestan Electric Power Distribution Company in Iran is used as a case study for this work to demonstrate the applicability of the proposed approach, analyze the findings, and derive relevant managerial insights.

Technology Transfer, Technological Progress and Economic Growth: The Role of Institutional Quality in Pakistan

This study investigates the role of institutions in Pakistan’s efforts to stimulate technological progress, specifically analysing the evolution of institutional quality, technology transfer through technical cooperation grants, technological progress and economic growth. The role of institutional quality is emphasised, as proactive institutional coordination is paramount to achieve technological upgrading. As the evidence amassed shows, Pakistan’s institutional quality ranks lower than the successful industrialisers of East Asia, such as Japan, Korea and Taiwan. To ensure the robustness of our findings, data from 1996 to 2020 was deployed. The findings underscore the importance of policymakers in Pakistan directing their attention to fostering skills and competencies essential for patents or cultivating an entrepreneurial mindset, underlining the critical role of strong institutions in this process.

Endoscopic-Assisted Anterior Petrosectomy for a Recurrent Petrous Chondrosarcoma in Ollier Disease: 2-Dimensional Operative Video

Ollier disease (OD) is characterized by the formation of multiple enchondromas. Patients with OD can develop malignant tumors, most often chondrosarcomas. When chondrosarcomas occur at the skull base in OD, cure is often difficult to obtain by surgery being lesion limits poorly distinguishable within the extensive pathological bone. Owing to the possible multiplicity of lesions over time, radiotherapy, in particular proton therapy, should be used with caution. The goal of surgery is therefore maximal resection with functional preservation followed with a careful follow-up. In this video, the case of a 13-year-old girl with an OD and an incidentally found petrous apex chondrosarcoma is presented. An endoscopic endonasal biopsy was performed confirming the diagnosis of chondrosarcoma. Conservative management was chosen initially. Because of symptoms progression and significant tumor growth, surgical removal was proposed. Considering the limited pneumatization of the sphenoid sinus and the lateral location of the lesion, an endoscopic-assisted anterior petrosal approach was chosen. A small remnant of tumor was left below the internal auditory canal. Because of its progressive growth, an additional resection using the same surgical approach was performed, with additional anterior petrosal drilling along and below the cochlea under endoscopic guidance to remove the part of the lesion located under the internal auditory canal. Ultimately, gross total resection of the lesion was achieved. All human studies have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. The patient's relatives provided informed consent to the surgical treatment, video recording, and publication of the data. The patient's relatives provided consent to the procedures. This work was performed according to the ethical standards of our Institutional Review Board, without the need for dedicated IRB approval.

Assessment of the Development of Social Economic Impact through Tourism Events in Zanzibar

This research centers on evaluating the socio- economic repercussions of tourism events in the Urban District of Zanzibar. Utilizing a mixed-methods approach, data were gathered through questionnaires and interviews. Qualitative data underwent content analysis, while quantitative data were analyzed using percentages and frequencies via SPSS software. Findings reveal that a majority of participants recognize the significant role of tourism events in Zanzibar's socio- economic advancement. These benefits encompass employment creation, income generation, market expansion, linguistic diversity, and cultural interchange, among others. Stakeholders in the tourism sector have adopted strategies like cultural preservation, environmental conservation, and hospitality promotion to enhance tourism events. Nevertheless, challenges like deficient institutional capacity, limited community engagement, insufficient infrastructure, and religious beliefs present hurdles to the growth of tourism events and socio-economic progress in Zanzibar. The study suggests that the government and stakeholders should efficiently employ existing strategies to tackle these obstacles and enhance tourism events in Zanzibar, underlining the importance of collaborative endeavors among all involved parties.