Descriptive study. The First Affiliated Hospital of Shaoyang University, China, from September 2018 to February 2020. One hundred and seventy primiparous women, who had vaginal delivery and required labour analgesia, were randomly divided into Groups A and B (n=85 for each group). In both groups, PIEB plus PCEA mode was applied when cervical dilatation reached 2-3 cm. The interval was 30 minutes with a pulse dose of 5 mL in Group A; and 60 minutes with a pulse dose of 10 mL in Group B. Indicators related to body temperature and serum markers were compared in both the groups. Maternal temperature in Group A was higher than that in Group B at the time of cervix being completely dilated, and 2 hours after delivery (both p <0.001). incidence of intrapartum fever in Group A was higher than that in Group B (p = 0.036). Epidural analgesic dosage, VAS score, serum CRP, TNF-α, and IL-6 levels in Group A were higher than those in Group B at two hours after delivery (all p <0.001). PIEB plus PCEA mode at regular intervals of 60 minutes can reduce epidural analgesic dosage and incidence of intrapartum fever during delivery, thus exerting better analgesic effects. Key Words: Programmed intermittent epidural bolus (PIEB), Patient-controlled epidural analgesia (PCEA), Delivery, Analgesia, Parturient, Body temperature.