Programmable Circuit Research Articles

High-resolution and programmable RNA-IN and RNA-OUT genetic circuit in living mammalian cells

RNAs and their encoded proteins intricately regulate diverse cell types and states within the human body. Dysregulated RNA expressions or mutations can lead to various diseased cell states, including tumorigenesis. Detecting and manipulating these endogenous RNAs offers significant promise for restoring healthy cell states and targeting tumors both in research and clinical contexts. This study presents an RNA-IN and RNA-OUT genetic circuit capable dynamically sensing and manipulating any RNA target in a programmable manner. The RNA-IN module employes a programmable CRISPR-associated protease (CASP) complex for RNA detection, while the RNA-OUT module utilizes an engineered protease-responsive dCas9-VPR activator. Additionally, the CASP module can detect point mutations by harnessing an uncovered dual-nucleotide synergistic switching effect within the CASP complex, resulting in the amplification of point-mutation signals from initially undetectable levels (1.5-fold) to a remarkable 94-fold. We successfully showcase the circuit’s ability to rewire endogenous RNA-IN signals to activate endogenous progesterone biosynthesis pathway, dynamically monitor adipogenic differentiation of mesenchymal stem cells (MSCs) and the epithelial-to-mesenchmal trans-differentiation, as well as selective killing of tumor cells. The programmable RNA-IN and RNA-OUT circuit exhibits tremendous potential for applications in gene therapy, biosensing and design of synthetic regulatory networks.

Universal quantum operations and ancilla-based read-out for tweezer clocks

Enhancing the precision of measurements by harnessing entanglement is a long-sought goal in quantum metrology1,2. Yet attaining the best sensitivity allowed by quantum theory in the presence of noise is an outstanding challenge, requiring optimal probe-state generation and read-out strategies3–7. Neutral-atom optical clocks8, which are the leading systems for measuring time, have shown recent progress in terms of entanglement generation9–11 but at present lack the control capabilities for realizing such schemes. Here we show universal quantum operations and ancilla-based read-out for ultranarrow optical transitions of neutral atoms. Our demonstration in a tweezer clock platform9,12–16 enables a circuit-based approach to quantum metrology with neutral-atom optical clocks. To this end, we demonstrate two-qubit entangling gates with 99.62(3)% fidelity—averaged over symmetric input states—through Rydberg interactions15,17,18 and dynamical connectivity19 for optical clock qubits, which we combine with local addressing16 to implement universally programmable quantum circuits. Using this approach, we generate a near-optimal entangled probe state1,4, a cascade of Greenberger–Horne–Zeilinger states of different sizes, and perform a dual-quadrature5 Greenberger–Horne–Zeilinger read-out. We also show repeated fast phase detection with non-destructive conditional reset of clock qubits and minimal dead time between repetitions by implementing ancilla-based quantum logic spectroscopy20 for neutral atoms. Finally, we extend this to multi-qubit parity checks and measurement-based, heralded, Bell-state preparation21–24. Our work lays the foundation for hybrid processor–clock devices with neutral atoms and more generally points to a future of practical applications for quantum processors linked with quantum sensors25.

Integrated thermo-optic phase shifters for laser-written photonic circuits operating at cryogenic temperatures

Abstract Integrated photonics offers compact and stable manipulation of optical signals in miniaturized chips, with the possibility of changing dynamically their functionality by means of integrated phase shifters. Cryogenic operation of these devices is becoming essential for advancing photonic quantum technologies, accommodating components like quantum light sources, single photon detectors and quantum memories operating at liquid helium temperatures. In this work, we report on a programmable glass photonic integrated circuit (PIC) fabricated through femtosecond laser waveguide writing (FLW) and controlled by thermo-optic phase shifters both in a room-temperature and in a cryogenic setting. By taking advantage of a femtosecond laser microstructuring process, we achieved reliable PIC operation with minimal power consumption and confined temperature gradients in both conditions. This advancement marks the first cryogenically-compatible programmable FLW PIC, paving the way for fully integrated quantum architectures realized on a laser-written photonic chip.

Region‐selective shift register by a single output enable signal for a multiple refresh frequency driving scheme

AbstractMany low‐power technologies have been developed for high‐performance displays. One method is to vary the refresh rate according to the input image, where frequencies are reduced over still images and slow‐moving videos. To support the variable refresh rate scheme, the programmable gate driver circuit should be integrated. This paper proposes a thin‐film transistor (TFT) shift register of which output pulse is simply controlled by an enable signal. Because the output pulse generation is directly adjusted without the previous programming period, various output pulse sequences are possible with the high flexibility. The shift register is composed by adding six TFTs and one capacitor to a conventional circuit that provides a carry pulse to a next stage. The simulation program with integrated circuit emphasis (SPICE) simulation ensures that gate pulses for any numbers of lines in any regions can be generated within one frame only by applying the enable signal at the corresponding timing, resulting in multiple refresh frequencies in a screen. In addition, it is verified that additional TFTs and capacitor contribute to only the negligible increase in power consumption by 2.1%, compared to a conventional shift register.

Information processing at the speed of light.

In recent years, quantum computing has made significant strides, particularly in light-based technology. The introduction of quantum photonic chips has ushered in an era marked by scalability, stability, and cost-effectiveness, paving the way for innovative possibilities within compact footprints. This article provides a comprehensive exploration of photonic quantum computing, covering key aspects such as encoding information in photons, the merits of photonic qubits, and essential photonic device components including light squeezers, quantum light sources, interferometers, photodetectors, and waveguides. The article also examines photonic quantum communication and internet, and its implications for secure systems, detailing implementations such as quantum key distribution and long-distance communication. Emerging trends in quantum communication and essential reconfigurable elements for advancing photonic quantum internet are discussed. The review further navigates the path towards establishing scalable and fault-tolerant photonic quantum computers, highlighting quantum computational advantages achieved using photons. Additionally, the discussion extends to programmable photonic circuits, integrated photonics and transformative applications. Lastly, the review addresses prospects, implications, and challenges in photonic quantum computing, offering valuable insights into current advancements and promising future directions in this technology.

Advancing Programmable Information Encryption Circuits Through Colorful Phosphorescent Carbon Nanodots with Versatile Lifetimes

AbstractOptical encryption technology attracts considerable attention in the field of information encryption, information storage, and anti‐counterfeiting. However, optical encryption based on conventional on/off mode still faces issues such as low scalability, ease of cracking, and poor storage capacity; multi‐dimensional and high storage capacity information encryption systems are thus needed. Herein, a programmable information encryption circuit system is demonstrated by constructing a delay light‐emitting diode (LED) array using multi‐color phosphorescent carbon nanodots (CNDs) with versatile lifetimes. The CNDs show adjustable luminescence wavelength and lifetime from 192 to 1148 ms. The programmable delay luminescent circuit provides an intricate framework for meticulously integrating an LED array, enabling the creation of intricate patterns or alphanumeric codes. These intricate designs are engineered to serve as a component of an encryption system, which can be deciphered and unveiled under a specific delay time range. This study demonstrates the feasibility and superiority of the system as a new type of information anti‐counterfeiting encryption technology, providing a new concept for exploring the field of integrated circuit anti‐counterfeiting and encryption.

Field-free multistate spin–orbit torque devices for programmable image edge recognition circuit

The application of spin–orbit torque (SOT) devices to neuromorphic computing platforms is focused on the development of hardware circuit architectures. However, the inter-device variability, the integration modes of devices and peripheral circuits, and appropriate application scenarios are still unclear, limiting the development of SOT devices in neuromorphic computing. To solve this problem, this paper first proposes a circuit compensation scheme for the difference in resistance values of SOT devices, which solves this variability problem at the circuit level. Moreover, a synergistic scheme with the circuit is developed based on the correspondence between the multistate resistance characteristics of the SOT devices and a convolutional algorithm. To achieve this, a multichannel SOT convolutional kernel circuit architecture is built, which implements an image edge recognition application. Finally, based on a simulation model, an image edge recognition hardware circuit based on our CoPt-SOT devices is implemented, which is capable of performing image edge recognition with an accuracy of 96.33%. This scheme provides technical support and development prospects for SOT devices in neural network hardware applications.

Ultra-low-power consumption silicon electro-optic switch based on photonic crystal nanobeam cavity

Ultra-low-power consumption and high-speed integrated switches are highly desirable for future data centers and high-performance optical computers. In this study, we proposed an ultra-low-power consumption silicon electro-optic switch based on photonic crystal nanobeam cavities on a foundry platform. The proposed switch showed an ultra-low static-tuning power of 0.10 mW and a calculated dynamic switching power of 6.34 fJ/bit, with a compact footprint of 18 μm × 200 μm. Additionally, a 136-Gb/s four-level pulse amplitude modulation signal transmission experiment was carried out to verify the capability of the proposed electro-optic switch to support high-speed data transmission. The proposed device has the lowest static-tuning power consumption among silicon electro-optic switches and the highest data transmission rate. The results demonstrate the potential applications of this switch in high-performance optical computers, data center interconnects, optical neural networks, and programmable photonic circuits.

Programmable Analog Circuits with Neuromorphic Nanostructured Platinum Films

AbstractSelf‐assembled nanoparticle or nanowire networks have recently come under the spotlight as systems able to emulate brain‐like data processing performances by exploiting the memristive character and the wiring of the junctions connecting the nanostructured network building blocks. Recently it is demonstrated that nanostructured Au films, fabricated by the assembling of gold clusters produced in the gas phase, have non‐linear and non‐local electric conduction properties caused by the extremely high density of grain boundaries and the resulting complex arrangement of nanojunctions. These observations suggest that nanostructured metallic films can be explored and exploited as a novel class of neuromorphic systems for unconventional electronic devices. Here it is reported that nanostructured cluster‐assembled Pt films show resistive switching activity, negative differential resistance, and reversible memory effects. These properties allow the use of nanostructured Pt films in programmable analog circuits, such as gain amplifiers and relaxation oscillators with fast response.

Diagnostics of Ship Engines Based on Wavelet Neural Network and Image Scanning Using Programmable Logic Circuit

Diagnostics of Ship Engines Based on Wavelet Neural Network and Image Scanning Using Programmable Logic Circuit

Design and Application of Programmable Analog Circuit for Solving Lyapunov Matrix Equation Based on Memristors

Design and Application of Programmable Analog Circuit for Solving Lyapunov Matrix Equation Based on Memristors

Quantum states generation and manipulation in a programmable silicon-photonic four-qubit system with high-fidelity and purity

We present a programmable silicon photonic four-qubit integrated circuit for the generation and manipulation of diverse quantum states. The silicon photonic chip integrates photon-pair sources, pump-reducing filters, wavelength-division-multiplexing filters, Mach–Zehnder interferometer switches, and single-qubit arbitrary gates, enabling versatile state preparation and tomography. We measure Hong–Ou–Mandel interference with an impressive 98% visibility using four-photon coincidence, laying the foundation for high-purity qubits. Our analysis involves estimating the fidelity and purity of distinct quantum states through maximum-likelihood estimation applied to tomographic measurements. In our experimental results, we showcase the following achievements: a heralded single qubit achieving 98.2% fidelity and 98.3% purity, a Bell state reaching 95.2% fidelity and 94.8% purity, and a four-qubit system with two simultaneous Bell states exhibiting 87.4% fidelity and 84.6% purity. Finally, a four-qubit Greenberger–Horne–Zeilinger (GHZ) state demonstrates 85.4% fidelity and 81.7% purity. In addition, we certify the entanglement of the four-photon GHZ state through Bell’s inequality violations and a negative entanglement witness.

On-chip tunable quantum interference in a lithium niobate-on-insulator photonic integrated circuit

Programmable interferometric circuits are at the heart of integrated quantum photonic processors. While the lithium niobate-on-insulator platform has the potential to advance integrated quantum photonics due to its strong nonlinearity and tight mode confinement, the demonstration of reconfigurable two-photon interference has not yet been achieved. Here, we design, fabricate and characterize the building block of such interferometric networks in the form of a 2 × 2 Mach–Zehnder Interferometer. We use a thermo-optic phase shifter to achieve stable performance with a power consumption of Pπ=44.4 mW and sub-microsecond switching times. We demonstrate the effectiveness of our device for quantum applications by measuring single-photon routing with up to 34 dB extinction ratio. We show Hong-Ou-Mandel interference with fully tunable visibilities reaching a maximum value of 97.4±1.0% . As part of large scale quantum photonic circuits, this building block will facilitate reconfigurable and tunable photonic processing units integrated alongside non-classical light sources.

The Goldilocks principle of learning unitaries by interlacing fixed operators with programmable phase shifters on a photonic chip

Programmable photonic integrated circuits represent an emerging technology that amalgamates photonics and electronics, paving the way for light-based information processing at high speeds and low power consumption. Programmable photonics provides a flexible platform that can be reconfigured to perform multiple tasks, thereby holding great promise for revolutionizing future optical networks and quantum computing systems. Over the past decade, there has been constant progress in developing several different architectures for realizing programmable photonic circuits that allow for realizing arbitrary discrete unitary operations with light. Here, we systematically investigate a general family of photonic circuits for realizing arbitrary unitaries based on a simple architecture that interlaces a fixed intervening layer with programmable phase shifter layers. We introduce a criterion for the intervening operator that guarantees the universality of this architecture for representing arbitrary N×N\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$N \ imes N$$\\end{document} unitary operators with N+1\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$N+1$$\\end{document} phase layers. We explore this criterion for different photonic components, including photonic waveguide lattices and meshes of directional couplers, which allows the identification of several families of photonic components that can serve as the intervening layers in the interlacing architecture. Our findings pave the way for efficiently designing and realizing novel families of programmable photonic integrated circuits for multipurpose analog information processing.

Erasable and Field Programmable DNA Circuits Based on Configurable Logic Blocks.

DNA is commonly employed as a substrate for the building of artificial logic networks due to its excellent biocompatibility and programmability. Till now, DNA logic circuits are rapidly evolving to accomplish advanced operations. Nonetheless, nowadays, most DNA circuits remain to be disposable and lack of field programmability and thereby limits their practicability. Herein, inspired by the Configurable Logic Block (CLB), the CLB-based erasable field-programmable DNA circuit that uses clip strands as its operation-controlling signals is presented. It enables users to realize diverse functions with limited hardware. CLB-based basic logic gates (OR and AND) are first constructed and demonstrated their erasability and field programmability. Furthermore, by adding the appropriate operation-controlling strands, multiple rounds of programming are achieved among five different logic operations on a two-layer circuit. Subsequently, a circuit is successfully built to implement two fundamental binary calculators: half-adder and half-subtractor, proving that the design can imitate silicon-based binary circuits. Finally, a comprehensive CLB-based circuit is built that enables multiple rounds of switch among seven different logic operations including half-adding and half-subtracting. Overall, the CLB-based erasable field-programmable circuit immensely enhances their practicability. It is believed that design can be widely used in DNA logic networks due to its efficiency and convenience.

Programmable Entropy-Driven Circuit-Cascaded Self-Feedback DNAzyme Network for Ultra-Sensitive Fluorescence and Photoelectrochemical Dual-Mode Biosensing.

Inspired by natural DNA networks, programmable artificial DNA networks have become an attractive tool for developing high-performance biosensors. However, there is still a lot of room for expansion in terms of sensitivity, atom economy, and result self-validation for current microRNA sensors. In this protocol, miRNA-122 as a target model, an ultrasensitive fluorescence (FL) and photoelectrochemical (PEC) dual-mode biosensing platform is developed using a programmable entropy-driven circuit (EDC) cascaded self-feedback DNAzyme network. The well-designed EDC realizes full utilization of the DNA strands and improves the atomic economy of the signal amplification system. The unique and rational design of the double-CdSe quantum-dot-released EDC substrate and the cascaded self-feedback DNAzyme amplification network significantly avoids high background signals and enhances sensitivity and specificity. Also, the enzyme-free, programmable EDC cascaded DNAzyme network effectively avoids the risk of signal leakage and enhances the accuracy of the sensor. Moreover, the introduction of superparamagnetic Fe3O4@SiO2-cDNA accelerates the rapid extraction of E2-CdSe QDs and E3-CdSe QDs, which greatly improves the timeliness of sensor signal reading. In addition to the strengths of linear range (6 orders of magnitude) and stability, the biosensor design with dual signal reading makes the test results self-confirming.

Photo-controlled programmable logic gate via self-powered Cu2O/BiFeO3/TiO2 ferroelectric heterojunction photodetectors

The increased demands for high integration, fast computation, and a wide range of data processing in digital logic circuits have triggered an interest in programmable logic gates that can run different logic operations. Photodetectors (PDs) based on ferroelectric materials can obtain different ferroelectric polarization states utilizing pre-biased voltage regulation to achieve programmable logic functions, but low photoelectric conversion efficiency and slow photoresponse speed are still key problems to be addressed for programmable logic gate devices. Herein, the Cu2O/BiFeO3(BFO)/TiO2 ferroelectric heterojunction PDs were constructed by introducing a p-type hole transport layer Cu2O on the BFO/TiO2 ferroelectric heterojunction films, which not only broadens the photoresponse spectra range to the red light, but also forms a stepped energy band structure at the heterojunction interface, and the interfacial electric field promotes the separation and transport of photogenerated carriers, improving the self-powered photodetection performance of the devices. The Cu2O/BFO/TiO2 PDs demonstrate a responsivity of 3.0 mA/W and a photoresponse rise time/decay time of 2.3/23.9 ms at 420 nm light illumination. The Cu2O/BFO/TiO2 PD can be polarized in different states by pre-biased voltage and outputs different electrical signal values under the ultraviolet (365 nm) and visible (420 nm) monochromatic light or the mixed light irradiation, thus the device can realize the "AND" gate output in the positive bias polarization state and the "OR" gate output in the negative bias polarization state, which shows that the ferroelectric heterojunction PDs has a great potential application in the field of photo-controlled programmable logic gate circuits.

Development of an Electronic Actuating Control Mechanism to Operate a Remotely Controlled 2-Wheel Rice Transplanter

Mechanical transplanters are adopted to reduce human drudgery in manual transplanting. Different types of manual and self-propelled paddy transplanters are commercially available. The human involvement is higher for operating a 2-wheel paddy transplanter operator has to walk 10-22 km behind the machine in a day in puddled field conditions under high temperature (38-440 C) and humid conditions (70-80% RH) in summer. Besides that, the operator has to walk within the 30 cm row width, which causes chafing between the thighs of an operator. To reduce the physical and physiological workload of an operator, an integrated control lever actuating mechanism with gear motors was developed to operate a 2-wheel paddy transplanter remotely. The inductive proximity sensors (SN04-N distance detector) were used to control the crank rotation position of the gear motors, motor drives (BTS 7960), and microcontroller (STM32F4) was used to connect with the auto-driver kit to control the motor mechanism and sensors. The auto-driver kit consisted of a variety of accessories, a physical programmable circuit board, and software, that runs on a PC, used to write and upload computer code as a simplified version of C++ to the physical board. Although the initial cost of the machine with the developed system has been increased up to 28%, but at the same time the effective field capacity has been increased from 0.158 ± 0.02 ha h-1 to 0.175 ± 0.04, resulting the area covered per day and per year has also increased up to 11%. With the development of remotely controlled system, the labor requirement has been reduced from 20± 1 to 13± 1 man h ha-1, which results reduction up to 40%. Moreover, the human fatigue in terms of physical and physiological work load involved while walking behind the transplanter has been eliminated at much extent. As compared to the existing walk-behind type paddy transplanter, the net profit with the developed system rise up to 18.50 to 26.61 % per year and a boost of 34.10 to 51.63% in benefit-cost ratio. Field evaluation of a developed remote-controlled system for a two-wheel rice transplanter would be viable, reducing fatigue among machine operators/farm workers while increasing work productivity and safety.

Universal silicon ring resonator for error-free transmission links

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of ∼4 V·mm and >8 dB optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate ≤3×10−12. Individually, the speed of modulation and detection is measured up to 112 Gb/s and 80 Gb/s, respectively. The principle of co-designing the PN junction ring modulator and detector performance required for error-free communication links can significantly ease the fabrication yield challenges of ring structures by reducing the number of types of devices. The principle can also be applied to O band wavelengths. To the best of our knowledge, for the first time, a device of this type has achieved both error-free modulation and detection operation up to 50 Gb/s in the C band individually or in conjugation as an error-free communication link, which paves the way to realize a >1.6 Tb/s all-silicon WDM-based error-free optical transceiver link in the future and is essential for future programmable photonics circuits.

Isothermal Reciprocal Catalytic DNA Circuit for Sensitive Analysis of Kanamycin.

Inappropriate use of veterinary drugs can result in the presence of antibiotic residues in animal-derived foods, which is a threat to human health. A simple yet efficient antibiotic-sensing method is highly desirable. Programmable DNA amplification circuits have supplemented robust toolkits for food contaminants monitoring. However, they currently face limitations in terms of their intricate design and low signal gain. Herein, we have engineered a robust reciprocal catalytic DNA (RCD) circuit for highly efficient bioanalysis. The trigger initiates the cascade hybridization reaction (CHR) to yield plenty of repeated initiators for activating the rolling circle amplification (RCA) circuit. Then the RCA-generated numerous reconstituted triggers can reversely stimulate the CHR circuit. This results in a self-sufficient supply of numerous initiators and triggers for the successive cross-invasion of CHR and RCA amplifiers, thus leading to exponential signal amplification for the highly efficient detection of analytes. With its flexible programmability and modular features, the RCD amplifier can serve as a universal toolbox for the high-performance and accurate sensing of kanamycin in buffer and food samples including milk, honey, and fish, highlighting its enormous promise for low-abundance contaminant analysis in foodstuffs.