Background and Aims The most essential and common sports injury in the lower limb in many sports fields is the injury of the anterior cruciate ligament (ACL). Knowledge in this field and appropriate exercise programs can help prevent this injury for all athletes and coaches. The present research aims to investigate the prevalence of this injury in different sports fields and the results of various training programs in reducing the risk of injury to ACL. Methods The current review was conducted using international information resources, Scopus, Taylor and Francis, ProQuest, Emerald Insight, ScienceDirect, Springer, Web of knowledge, and internal information resources including Magiran, Civilica, SID, and Iran Medex were applied. The research date range was defined between 2000 to 2020. In international articles, keywords such as Single-leg Landing, Landing, Injury, Knee injury, Drop-landing, Training, Exercise, ACL, and in domestic papers, keywords such as ACL, Knee Injury, Single-leg Landing, Jump, Land, and Training program were considered. According to the exclusion criteria, only 42 articles were selected and examined out of 220. Results Women with this injury are more affected at all skill levels, so at the professional skill level, women were affected up to 5 times more than men, and at the amateur level, the infection rate is about 3 to 4 times higher. The highest incidence is related to women professional basketball players with a speed of 5.5 per 1000 athletes training, and the lowest is among amateur male athletes with a rate of 0.02 with the same criteria. Of the articles reviewed in the appropriate injury prevention training program, 32% examined the effect of neuromuscular training, 18% combined training, 26% strength training, and 24% central core stability training. With 80% effectiveness, core stability training seems to be the most effective injury prevention program. Conclusion Considering the rate of this injury and the impact of this injury on treatment costs, the duration of returning to exercise, and creating the ground for other injuries, a comprehensive review of exercises effective in preventing this injury for athletes and coaches it’s important. This is especially important for professional female basketball players due to the incidence rate. The central core stability training program had the most practical effect among the training programs. The combined training program had the least impact according to different criteria for assessing and preventing injury.