The isotopically light Fe signature of arc magmas relative to mid-oceanic ridge basalts (MORB) is expected to be related to the redox state of their source. This implies a link between Fe mobility and redox variations across subduction zones. Here we address slab chemical variations during prograde metamorphism through a comprehensive geochemical study, including major, trace elements and Fe stable isotope (ÎŽ56Fe) analyses, of meta-serpentinites composing the eclogitic meta-ophiolite of the Monviso massif (Western Alps, Italy). These rocks partly preserve mantle related geochemical heterogeneities, as supported by negative correlations between fluid immobile elements (High Field Strong Elements) and LREE/HREE (Light â Heavy Rare Earth Elements) ratios. They are however characterized by large Cs enrichments relative to U or alkali elements suggesting that abyssal fluid mobile elements signature was overprinted by subduction related processes. Meta-serpentinites display large ÎŽ56Fe variations, from -0.20 ± 0.05 â° to +0.09 ± 0.03 â°. Mineral separate analyses of olivine bearing veins show low Î56Fe between olivine and magnetite (⌠0.4 â°), which according to Fe isotope thermometry correspond to high temperature equilibration, estimated between 530 and 550 °C, compatible with Monviso metamorphic climax (520â570 °C and 2.6â2.7 GPa). These results, in combination with geochemical modelling, confirm a reset of ÎŽ56Fe signature of abyssal serpentinites during prograde metamorphism in subduction zones. The bulk rock ÎŽ56Fe values of Monviso meta-serpentinites are negatively correlated with their Fe3+/âFe and As concentrations (a redox-sensitive and fluid mobile element). These correlations can be attributed to a metasomatism by external fluids derived from slab serpentinites during subduction. It also concords with the oxygen fugacity (fO2) record in meta-serpentinites, with meta-serpentinites equilibrated at high fO2 displaying the lowest ÎŽ56Fe values while samples equilibrated at low fO2 display mantle like ÎŽ56Fe signatures. These results highlight that oxidising conditions during serpentinite dehydration are likely to boost isotopically light Fe mobility in slab derived fluids.