Trough mouth fans (TMFs) are major submarine depocentres that form in front of ice streams advancing onto the continental shelf, and they provide extensive records of past glaciations and ice-sheet dynamics. However, early research about TMFs was conducted using primarily 2D seismic data, which limits the insights on the deposit's geometries and internal structures and more recent studies using 3D data have focused on the general depositional history of TMFs. Here, we assess the spatial and temporal changes of the glacio-marine landforms and deposits throughout the last glacial-interglacial cycle (Marine Isotope Stage (MIS) 6 to 1, ∼130 ka to present) recorded in a >550 m thick progradational sequence. We use 3D reflection seismic data with significant vertical resolution (up to 2 m) imaging over 14000 km2 from the uppermost North Sea Fan (NSF) to document the seismic stratigraphy and sedimentary processes, by combining horizon picking and geomorphological analyses. The studied interval comprises five mappable units, four on the slope and one on the shelf, spanning from the modern seabed down to the top of the Tampen Slide (∼130 ka). Five different channel types (here included slide scars), as well as contourite and plumite packages are described based on their seismic facies, morphology, geometry, and stratigraphical position. We propose that contour currents are responsible for sediment delivery after the Tampen Slide deposition during the interglacial period before the onset of the Last Glacial Maximum, when high meltwater influx from the shelf produced turbidites. Sedimentation became debris-flow-dominated towards the end of the period of shelf-edge glaciation. The deglacial interval is characterized by the deposition of plumites on the slope. On the shelf, subglacial tills are deposited during both glacial and deglacial periods. We calculate an average sedimentation rate of <1 m/kyr during the interglacial (MIS 5-3), and around 50–65 m/kyr during the glacial and deglacial periods (MIS2-early MIS1). Thus, we document a change of two orders of magnitude in sedimentation rate during a glacial cycle on the slope of a glaciated margin.