The rapid development of cloud computing has generated numerous cloud service providers. In a three-tier cloud service architecture, maximizing the cloud service profit is not only a goal pursued by cloud service providers but also a potent force that drives the continuous development of cloud computing technology. The traditional methods of maximizing cloud service profits are either limited to cloud resource management or service request distribution. Few work contributes to maximizing the profit of cloud service providers while considering both resource management and request distribution. Besides, the heterogeneity of servers is also an important concern when configuring the multiserver system. Therefore, this paper proposes a multiserver configuration and request distribution framework oriented to a three-tier cloud service architecture for maximizing the profit of cloud service providers. Compared with the benchmark method, extensive numerical simulation experiments show that our proposed framework can not only maximize the profit of cloud service providers, but also has a well-time efficiency.