Design thinking is generally defined as an analytic and creative process that engages a person in opportunities to experiment, create and prototype models, gather feedback, and redesign. Design Thinking Approach is adopted to carry out the research to correlate the knowledge and attitude among non-health professional students. Objectives: (a) To assess the pre-test and post-test level of knowledge and attitude regarding organ donation among non-health professional students. (b) To assess the effectiveness of computer assisted teaching on knowledge and attitude regarding organ donation among non-health professional students. (c)To find out the association between post-test level of knowledge and attitude regarding organ donation and the selected demographic variables among non-health professional students. (d)To assess the correlation between knowledge and attitude regarding organ donation. Methodology: The research design used was a pre-experimental one group pretest and posttest design. The samples for the study were chosen by using convenient sampling technique, The sample size was 50. Results: Karl Pearson correlation test was used. It reveals that there is effectiveness present in the group. Conclusion: Organ donation is a huge public health concern worldwide. The biggest advantage to organ donation is, it saves lives that would otherwise be lost. A single organ donor has the chance to save the lives or improve the quality of life for several people. So, the organ donation should be encouraged and the people should be motivated to donate their organs by conducting periodical educational programmed regarding organ donation.