The aim of this study is to determine the effect of cooperation between physicians and nurses working in surgical clinics on the tendency of nurses to make medical errors. The research was carried out in a descriptive manner at Yozgat Bozok University Research and Application Center surgical units between April-May 2021. 130 surgical nurses and 40 surgeons were included in the study. In the evaluation of the data, independent two-sample t-test, Mann-Whitney U test, one-way analysis of variance, Duncan test, Kruskal Wallis test, Pearson correlation coefficient, and regression analysis were used. When the Jefferson Physician and Nurse Professional Collaboration Scale mean scores of physicians and nurses were examined; the mean score of nurses was 52.2±5.8, and the mean score of physicians was 50.7±4.6. Nurses' Malpractice Tendency Scale mean score was determined as 236.1±16.5. It was determined that when the Jefferson Physician and Nurse Professional Collaboration Scale score of the nurses increased by one unit, the Malpractice Tendency Scale score increased by 1.247. Statistically, it was determined that there was a weak positive relationship (p<0.05). The existence of a healthy and effective cooperation system between physicians and nurses in surgical units is important in preventing medical errors. In our study, it was determined that the physician-nurse relationship in surgical units had an effect on the medical error tendency of nurses. In line with the data obtained, it is recommended to measure the reflections of the trainings on the cooperation in order to increase the effective trainings in changing the professional communication within the team on doctor-nurse cooperation in a positive way and to strengthen the concrete data.