Poor utilization of nursing process can lead to poor quality of nursing care, disorganizarion of the service, conflicting roles, medication error, poor diseases prognosis, readmission, dissatisfaction with the care provided and increased mortality. Therefore, this study assessed determinants of nursing process utilization in University College Hospital (UCH), Ibadan. This study adopted a descriptive research design. A multi-stage sampling technique was adopted to select 296 respondents from all the thirty-two (32) wards at UCH while the sample size was determined using Slovin’s formula. Data were collected using the self-structured questionnaire developed by the researcher for the purpose of this study. Five research questions were raised to guide this study and tested at 0.05 level of significance using of simple percentages and Multiple Regression Analysis. The findings indicated that knowledge level of nurses on nursing process was high and adequate (86.3%) while nurses' utilization of nursing process was 56.2%. This study showed that attitudinal (R =.347, R 2 = .120, Adj. R 2 = .117, f (1,277) = 37.797; P = .000), institutional (R =.285, R 2 = .081, Adj. R 2 = .078, f (1,277) = 37.797; P = .000) and nurses' knowledge of nursing process (R =.194, R 2 = .038, Adj. R 2 = .034, f (1,277) = 10.830; P = .001) are determinants of the utilization of nursing process among nurses. Also, the nurses' age, gender, professional qualifications, professional cadre, and years of working experience failed to significantly influence the utilization of nursing process. The study concluded that nurses’ knowledge, attitude and institutional factors are core issues in the proper utilization of nursing process. Therefore, Effective and efficient implementation of the nursing process directly contributes to the quality of healthcare and the patients’ health outcomes. Keywords: Determinants, nursing process, utilization DOI : 10.7176/JHMN/70-05 Publication date: January 31 st 2020