Heavy metal (HM) toxicity is a serious concern across the globe owing to their harmful impacts on plants, animals, and humans. Zinc oxide nanoparticles (ZnO-NPs) have gained appreciable attention in mitigating the adverse effects of abiotic stresses. The exogenous application of ZnO-NPs induces tolerance against HMs by improving plant physiological, metabolic, and molecular responses. They also interact with potential osmolytes and phyto-hormones to regulate the plant performance under HM stress. Moreover, ZnO-NPs also work synergistically with microbes and gene expression which helps to withstand HM toxicity. Additionally, ZnO-NPs also restrict the uptake and accumulation of HMs in plants which improves the plant performance. This review highlights the promising role of ZnO-NPs in mitigating the adverse impacts of HMs in plants. In this review, we explained the different mechanisms mediated by ZnO-NPs to counter the toxic effects of HMs. We also discussed the interactions of ZnO-NPs with osmolytes, phytohormones, and microbes in mitigating the toxic effects of HMs in plants. This review will help to learn more about the role of ZnO-NPs to mitigate HM toxicity in plants. Therefore, it will provide new insights to ensure sustainable and safer production with ZnO-NPs in HM-polluted soils.
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