This paper takes into consideration the impact of stress sensitivity on bioenergy production from low permeability tight reservoirs, focusing on the post-fracturing phase. This paper established a trilinear flow model that effectively takes into account the dynamics of such reservoirs. This model incorporates stress sensitivity parameters and uses the perturbation transformation and Laplace transformation to solve the productivity prediction formula. The final productivity prediction curve post-fracturing is achieved through a numerical inversion method. This study shows that the stress sensitivity effect significantly diminishes the productivity of fractured horizontal wells used in bioenergy extraction. By introducing stress sensitivity effect parameters, this paper manages to uncover the influence law of mobility and artificial fracture parameters on productivity. Notably, as the reservoir mobility increases, the cumulative bioenergy production from fractured horizontal wells improves significantly. In addition to the above, this paper also scrutinizes the sensitivity of artificial fracture parameters and optimize both the quantity and length of these fractures. This plays a crucial role in enhancing the productivity and efficiency of bioenergy extraction from these tight reservoirs. The applicability and reliability of this method are extensively tested, thereby establishing its potential in guiding the development of low permeability reservoirs post-fracturing. Importantly, this research sets the groundwork for combining bioenergy production with Carbon Capture, Utilization, and Storage (CCUS) technologies. By focusing on optimization and stress management in tight reservoirs, this paper contributes to the sustainable production of bioenergy and reduce carbon emissions, moving a step closer to a cleaner and sustainable future.