Low-pressure gas wells are of increasing interest to the petroleum industry as economic and environmental importance of natural gas continues to grow. To maximize the production of low permeability gas reservoir, a novel production strategy to determine reasonable producing periods, including the pressure draw down process and the pressure build up process, in low pressure gas wells has been investigated. Additionally, the variation of down-hole pressure and gas flow in both processes were considered to formulate the optimization model to find reasonable switching times for low-pressure gas wells in this research. In order to enhance the adaptability of the production strategy proposed in this research, parameters of erosion flow rate, critical flow rate of liquid loading and reasonable differential producing pressure of the reservoirs were considered in the proposed mathematical model which aims at maximizing gas production of low-pressure gas wells. Based on the application of the mathematical model dealing with reasonable production strategy of low-pressure gas wells, the pressure of gas well varies smoothly in both shut-in process and gas production process when the novel production strategy was applied. And nature gas production of the gas well increases dramatically compared with that before.