Ultraviolet B radiation (UVB) often cause oxidative stress, through the reactive oxygen species (ROS) formation and produce DNA damage. This study aims to assess the protective effects of topically cocoa extract lotio against DNA damage by measure of 8-OHdG level in albino mice after UVB exposure. This study was conducted in Makassar, South Sulawesi, using 20 Swiss albino mice, aged 6-9 weeks, weight 20-30 grams. Mice were divided into 3 groups: The first group is a control group or negative control (without cocoa extract and without UVB exposure, consist 4 mice), the second is UVB control group exposure with UVB 450mJ / cm<sup>2</sup> three times a week for 12 weeks without topical cocoa extract (4 mice) and the third group is mice with extract cocoa 200, 400 and 800 ppm every day, 20 minutes before exposure with UVB 450mJ / cm2 three times a week for 12 weeks (each concentration of cocoa extracts consist of 4 mice). At 24 hours after last exposure all mice were terminated and excisional biopsy on the dorsal skin of the size of 1x1 cm and performed 8-OHdG ELISA. The results show there was significant difference (p <0.05) between the control group UVB with negative control and cocoa 800 ppm. The 800 ppm cocoa extract is the most effective to the reduction of 8-OhdG level.