Cross section data for the formation of 121,122,123,125,127Xe via proton induced reactions on 127I were critically analyzed. Three nuclear model codes (TALYS 1.9, ALICE-IPPE, and EMPIRE 3.2) were used to ensure the consistency and reliability of the experimental data. Utilizing a well-developed evaluation methodology, a recommended fit for each excitation function was obtained, based on theoretical predictions of nuclear models and experimental cross sections. By using the recommended/reference results, thick target yields were calculated for each production route and its associated impurity reactions. The indirect production of the radionuclides 121,122,123,125I was explored. Special attention was paid to standardization of cross section data for the production of the medically important radionuclides 127Xe and 123I via the routes 127I(p,n)127Xe and 127I(p,5n)123Xe(EC, β+)123I, respectively.