Production Losses Research Articles

Predicting the Potential Global Distribution of the Plum Fruit Moth Grapholita funebrana Treitscheke Using Ensemble Models

The plum fruit moth, Grapholita funebrana Treitschke, is one of the most significant borer pests, often causing huge economic losses in fruit production. However, the potential distribution range of this economically important pest is still poorly understood. For this study, we simulated an ensemble species distribution model to predict the spatiotemporal distribution pattern of G. funebrana at a global scale. The results show that the suitable habitats for this moth, under current environmental conditions, are mainly distributed in Europe; East Asia, including China and Japan; Central Asia; and some parts of America. In future projections, the suitable habitats are predicted to generally expand northward, while the suitable area will remain unchanged overall. However, the area of highly suitable habitat will decrease to only 17.49% of that found under current conditions. None of the nine factors used were revealed to be predominant predictors in terms of contributing to the model, suggesting that the integrated effects of these variables shape G. funebrana’s distribution. In this study, the distribution range that has been predicted, especially for the regions with a highly suitable habitat, poses a high risk of G. funebrana outbreaks, highlighting the urgency of pest management. Moreover, in the United States of America (USA) and Japan (for which G. funebrana distributions were not previously recorded), especially in areas highly suitable for this moth, monitoring and quarantine measures should be strengthened to prevent the colonization and further dispersal of this pest, as seen with its close relative G. molesta, which has become a cosmopolitan pest species, migrating from its native region (East Asia) to other continents, including the Americas.

Prevalence and associated risk factors of hydatidosis in cattle slaughtered at Wolaita Sodo municipality abattoir.

Hydatidosis, caused by the larval stage of the tapeworm Echinococcus granulosus, affect cattle by forming hydatid cyst in thier lungs, livers and pose great financial loss in animal production and country's economy by both direct and indirect effect. Despite its great economic and health importance, there is an absence of current information on cystic echinococcosis in cattle slaughtered at Wolaita Sodo municipality abattoir in Ethiopia. Current investigation determines the prevalence, organ distribution and fertility of hydatid cysts in cattle slaughtered at the Wolaita Sodo municipality abattoir in Ethiopia. A cross-sectional study was conducted from February, 2023, to October, 2023, at Wolaita Sodo municipality abattoir in southern Ethiopia, through regular meat examinations and cyst characterisation to determine the prevalence, organ distribution and fertility of hydatid cysts. The overall prevalence of hydatidosis recorede in current study was 17.9% (69/384) and has shown a statistically significant association (p < 0.05) with the body condition of cattle. However, there was no statistically significant association (p > 0.05) between the prevalence of hydatidosis and other risk factors such as sex, breed, production system and origin of animals. This study showed that the lungs and liver were the most affected organs in cattle, followed by the spleen and kidneys. On cyst characterisation, the majority of hydatid cysts were found sterile (55.4%) followed by fertile (38.8%) and calcified (8.7%) cysts. Out of 125 fertile hydatid cysts tested for survival, 18.8% (58/321) were viable and 20% (67/321) were nonviable. The finding of this study shows that cystic echinococcus was important health threat of the cattle and widespread in the internal organs of affected cattle causingsignificant economic loss by condemning edible organs that are not suitable for human consumption. Therefore, urgent and integreted preventive action is needed to disrupt the life cycle of cystic echinococcosis to tackle subsequent financial loss and risk of zoonosis to humans in the study area.

Strain Measurement for Composite Materials During Mechanical Testing Based on Fiber Bragg Grating Monitoring

Composite materials are widely used as repair materials in the oil and gas sector, particularly for vessels, piping, and pipelines. Inspection and monitoring of these composite repairs is a critical aspect of ensuring their integrity and long-term performance. The reason being that failure of composite repairs may lead to loss of production and incur additional costs for re-repair or equipment replacement. Conventionally, a visual inspection is generally performed to observe any irregularities on the external surface of the composite repairs. This will usually be followed by a series of Non-destructive Tests (NDT) to identify the extent of the damage. However, these NDT methods, merely allowing off-line testing in a local manner with complicated and heavy equipment, require extensive and time-consuming labour. Structural Health Monitoring (SHM) based on Fibre Bragg Grating (FBG) that utilizes strain-based signals is one of the best options for monitoring the damage mechanism in composite due to its unique advantages of light weight, high stability and reliability, a long-life cycle, and the ability to capture the online reading. In this paper, the application of the FBG monitoring approach was used to examine the strain characteristics of composite materials based on mechanical tests (tensile and flexural). Three types of samples were prepared to simulate the type of damage mechanism: healthy, delamination, and disbondment. Based on the results, it was shown that the FBG sensor has potential for detecting and distinguishing the types of failure mechanisms in composites, including cracks, delamination, and disbondment. Hence, it was suggested that the FBG sensor technology could be used for site deployment in industry.

A planning model for coal power exit scales based on minimizing idle and shortage losses: A case study of China

Owing to the rising energy demand and coal dependency in developing countries, the losses incurred from coal power exit are substantial, leading to a low willingness to exit and a high risk of tragedy of the commons. Concurrently, the normalization of peak loads and increasing penetration of renewable energy have exacerbated the contradiction between the overall electricity surplus and peak power shortages in these countries. In response to these challenges, we propose an optimal planning model for a coal power exit scale based on the minimization of losses from idle coal power and industrial power shortages. The main findings are presented as follows: First, compared with the coal power exit models guided by the energy trilemma, our model can reduce losses (the primary demand in developing countries) by at least 22 %, and, in some scenarios, it can increase the exit scale by up to 147 GW. Second, unlike existing methods that measure the overall impact of power shortages, our approach is better at capturing industries' production loss characteristics, which is important for developing countries (positioned in the production segment of the industrial chain), including the evolution patterns of resource and time losses, recovery trajectories of power interruptions, and main influencing factors. Third, China's optimal coal power exit scale for 2030 fluctuates between −7 and 282 GW, with total losses between 48.34 and 188.86 billion yuan. This study provides quantitative tools and decision-making references for optimizing coal power exit and power use.

Clinical implications and costs of in-hospital versus outpatient orthopedic surgeries

Objective: This article reviews clinical implications and costs associated with orthopedic surgeries performed in inpatient versusoutpatient settings. Methods: Studies spanning the publication period between 2000 and 2023 were included, exploring a variety of study designs. Results: Results indicate that outpatient surgeries are associated with lower rates of postoperative complications, shorter recovery times, and greater patient satisfaction, as well as with significantly lower direct and indirect costs. Analysis of postoperative complications suggests that factors such as the home recovery environment and early mobilization may contribute to improved clinical outcomes, corroborating existing literature on the safety and efficacy of outpatient surgeries. Faster recovery after outpatient surgeries was consistently observed, with patients returning to normal activities an average of two weeks earlier compared with those undergoing inpatient surgeries. The greater patient satisfaction with outpatient surgeries reflects the convenience of avoiding hospitalization, with less disruption to daily life and reduced anxiety associated with the hospital environment. In economic terms, outpatient surgeries have been shown to be a financially advantageous alternative, with reduced direct costs due to the lower hospital fees and nursing services required, as well as lower indirect costs due to reduced productivity loss and transportation expenses. Conclusion: Findings are particularly relevant in a context of increasing pressure to contain spending in the health system. Level of Evidence I; Systematic review of level I studies.

Synthesis of Solketal Catalyzed by Acid-Modified Pyrolytic Carbon Black from Waste Tires.

Solketal, a widely used glycerol-derived solvent, can be efficiently synthesized through heterogeneous catalysis, thus avoiding the significant product losses typically encountered with aqueous work-up in homogeneous catalysis. This study explores the catalytic synthesis of solketal using solid acid catalysts derived from recovered carbon blacks (rCBs), which are obtained through the pyrolysis of end-of-life tires. This was further converted into solid acid catalysts through the introduction of acidic functional groups using concentrated H2SO4 or 4-benzenediazonium sulfonate (BDS) as sulfonating agents. Additionally, post-pyrolytic rCB treated with glucose and subsequently sulfonated with sulfuric acid was also prepared. Comprehensive characterization of the initial and modified rCBs was performed using techniques such as elemental analysis, powder X-ray diffraction, thermogravimetric analysis, a back titration method, and both scanning and transmission electron microscopy, along with X-ray photoelectron spectroscopy. The catalytic performance of these samples was evaluated through the batch mode glycerol acetalization to produce solketal. The modified rCBs exhibited substantial catalytic activity, achieving high glycerol conversions (approximately 90%) and high solketal selectivity (around 95%) within 30 min at 40 °C. This notable activity was attributed to the presence of -SO3H groups on the surface of the functionalized rCBs. Reusability tests indicated that only rCBs modified with glucose demonstrated acceptable catalytic stability in subsequent acetalization cycles. The findings underscore the potential of utilizing end-of-life tires to produce effective acid catalysts for glycerol valorization processes.

Dissecting the invasion history of Spotted-Wing Drosophila (Drosophila suzukii) in Portugal using genomic data

BackgroundThe invasive pest Spotted-Wing Drosophila, Drosophila suzukii (Matsumura), causes extensive damage and production losses of soft-skinned fruits. Native to Asia, the species has now spread worldwide, with first reports in Portugal in 2012. In this study, we focus on the genomic signatures of the recent Portuguese invasion, in the context of worldwide patterns established in previous works. We analyzed whole genome pool sequencing data from three Portuguese populations (N = 240) sampled in 2019 and 2021.ResultsThe correlation of allele frequencies suggested that Portuguese populations are related to South European ones, indicating a Mediterranean invasion route. While two populations exhibited levels of genetic variation comparable to others in the invasive range, a third showed low levels of genetic diversity, which may result from a recent colonization of the region. Genome-wide analyses of natural selection identified ten genes previously associated with D. suzukii’s invasive capacity, which may have contributed to the species’ success in Portugal. Additionally, we pinpointed six genes evolving under positive selection across Portuguese populations but not in European ones, which is indicative of local adaptation. One of these genes, nAChRalpha7, encodes a nicotinic acetylcholine receptor, which are known targets for insecticides widely used for D. suzukii control, such as neonicotinoids and spinosyns. Although spinosyn resistance has been associated with mutations in the nAChRalpha6 in other Drosophila species, the putative role of nAChRalpha7 in insecticide resistance and local adaptation in Portuguese D. suzukii populations encourages future investigation.ConclusionsOur results highlight the complex nature of rapid species invasions and the role of rapid local adaptation in determining the invasive capacity of these species.

The health and economic burden of breathlessness, Australia, 2019: a national survey.

To examine the impact of breathlessness on quality of life, health care use, productivity loss, and economic costs in Australia. National internet-based survey of Australian adults drawn from a web-based survey panel (National Breathlessness Survey). Australian adults (18 years or older), nationally representative by age group, gender, state of residence, and postcode-based socio-economic status (Index ofRelative Socioeconomic Disadvantage quintile), 13-30 October2019. Quality of life assessed with the EQ-5D 5-level version (EQ-5D-5L) and visual analogue scale (EQ-VAS), health care use, productivity loss, and societal cost, each by severity of breathlessness (modified Medical Research Council [mMRC] dyspnoea scale; mMRC grade 1: mild breathlessness; mMRC grades 2-4: clinically important breathlessness). Of 10 072 adults who completed the survey, mild breathlessness was reported by 3044 respondents (30.2%), and clinically important breathlessness by 961 (9.5%). The mean EQ-VAS score was 74.8 points (95% confidence interval [CI], 74.3-75.3 points) and the mean EQ-5D-5L score 0.846 (95% CI, 0.841-0.850) for respondents with mMRC grade 0 breathlessness; for each measure, the mean value declined with increasing severity of breathlessness (trends: each P < 0.001). Respondents with clinically important breathlessness were more likely than those with mild breathlessness to report non-urgent general practitioner visits, urgent general practitioner visits, and specialist visits (exception: mMRC scores of 4) during the preceding year. Among the 2839 respondents of working age, the likelihood of being employed declined with increasing breathlessness severity (mMRC grades 4 v 1: adjusted odds ratio, 0.34; 95% CI, 0.22-0.53). Adjusted mean annual societal cost per person was $1413 (95% CI, $1326-1501) for respondents with mMRC grade 1 breathlessness, $2065 (95% CI, $1766-2365) at mMRC grade 2, $1795 (95% CI, $1371-2218) at mMRC grade 3, and $2075 (95% CI, $1389-2762) at mMRC grade 4. Breathlessness imposes major burdens on individuals, the health care system, and the economy.

Effect of METTL3 Gene on Lipopolysaccharide Induced Damage to Primary Small Intestinal Epithelial Cells in Sheep.

Newborn lambs are susceptible to pathogenic bacterial infections leading to enteritis, which affects their growth and development and causes losses in sheep production. It has been reported that N6-methyladenosine (m6A) is closely related to innate immunity, but the effect of m6A on sheep small intestinal epithelial cells (IECs) and the mechanism involved have not been elucidated. Here, we investigated the effects of m6A on lipopolysaccharide (LPS)-induced inflammatory responses, apoptosis and oxidative stress in primary sheep IECs. First, the extracted IECs were identified by immunofluorescence using the epithelial cell signature protein cytokeratin 18 (CK18), and the cellular activity of IECs induced by different concentrations of LPS was determined by the CCK8 assay. Meanwhile, LPS could induce the upregulation of mRNA and protein levels of IECs cytokines IL1β, IL6 and TNFα and the apoptosis marker genes caspase-3, caspase-9, Bax, and apoptosis rate, reactive oxygen species (ROS) levels and mRNA levels of CAT, Mn-SOD and CuZn-SOD, and METTL3 were found to be upregulated during induction. It was hypothesized that METTL3 may have a potential effect on the induction of IECs by LPS. Overexpression and knockdown of METTL3 in IECs revealed that a low-level expression of METTL3 could reduce the inflammatory response, apoptosis and ROS levels in LPS-induced IECs to some extent. The results suggest that METTL3 may be a genetic marker for potential resistance to cellular damage.

Skin Factor Test Experiment of the Combined Structure of Blind and Screen Pipes

During the drilling process of horizontal wells in offshore oil fields, when encountering highly clayey shale or sandy shale sections, a common practice is to use a combination of blank pipes and screen pipes in the completion column to isolate high clay content layers. This helps prevent significant clay blockage in the screen pipes or wellbore, thereby reducing production loss. However, when blank pipes cannot effectively isolate clayey or sandy shale sections, the migration of clay content can lead to screen pipe blockage, adversely affecting production capacity. Given the current lack of evaluation methods for the impact of combined blank and screen pipe completion columns on production capacity, an experiment was designed to evaluate the skin factor of the completion column with a combination of blank and screen pipes. Through the calculation of the skin factor, the variation patterns of the skin factor for completion columns with blank and screen pipes under different conditions were obtained. These findings were then applied to a production evaluation. The research results revealed the following: (1) As the proportion of blind pipes increases, the skin factor of the combination of blind pipes and screen pipes in the completion tubing also increases. Excessive blind pipe ratios reduce production capacity. (2) In cases where the annular space is not completely filled, the influence of the blind pipe proportion on production capacity can be negligible. However, when the annular space is 100% filled, a higher proportion of blind pipes and silt content results in a larger skin factor, which leads to reduced production. In the application of the XH horizontal well case study, using the calculated model for the skin factor of the combination of blind pipes and screen pipes in the completion tubing established in this paper, it was determined that when the annular space was not completely blocked and 20 m of blind pipes were not placed in the designated position, the impact on the production index was 0.73%. However, when the blind pipes were not placed in the designated position for 100 m, the impact on the production index reached 1.47%. The method developed in this paper provides theoretical guidance for the optimization of completion tubing in mudstone and sandy mudstone sections and for production evaluation.

Comprehensive drought risk assessment and mapping in Taiwan: An ANP-ANN ensemble approach

This study aims to comprehensively evaluate and map the risk of drought in Taiwan by employing a combination of two powerful models, the Analytic Network Process (ANP) and Artificial Neural Network (ANN). This innovative approach utilizes an ensemble learning method, where ANP constructs a logical network and assigns weights to various indicators. Subsequently, ANN leverages these weights to train the model effectively. A total of twenty indicators were incorporated into the analysis to create a holistic drought risk map for Taiwan. These indicators are thoughtfully categorized into three essential components: hazard, exposure, and vulnerability, providing a well-defined representation of drought risk. The trained ANN model showcases remarkable accuracy and performance, boasting values of 0.940 for accuracy, 0.946 for precision, 0.938 for recall, 0.942 for the F1 score, and 0.923 for the Kappa Index. These results unequivocally affirm the model's effectiveness in predicting drought risk. Furthermore, the final drought risk map underwent rigorous validation through fieldwork and statistical data. The validation process yielded high accuracies, ranging from 0.717 to 0.851, for assessing damage to crops, converted damaged areas, and estimated value product loss. This validation, conducted against multiple reference data sources, underscores the map's reliability and its alignment with various goodness-of-fit criteria. In summary, this study underscores the potency of the ANP-ANN ensemble approach, with the trained ANN model proving its robustness in swiftly predicting drought risk across diverse ecological and socioeconomic scenarios.

Screening and Physiological Responses of Maize Inbred Lines to Drought Stress in South China

The frequent occurrence of localized and seasonal droughts has caused severe economic losses in maize production in South China. To promote sustainable maize production, selecting and breeding drought-tolerant varieties is vital for addressing water scarcity. Drought stress affects all aspects of crop morphological performance. In this study, the morphological performance of 285 maize inbred lines under drought stress was investigated using D-value analysis, correlation analysis, principal component analysis, cluster analysis and stepwise regression analysis. All indicators were significantly different in the regular treatment compared to the drought treatment. Specifically, survival rate, root fresh weight, root dry weight, plant dry weight, root/crown ratio, and plant fresh weight were used as indicators for drought-tolerance evaluation. Furthermore, the drought-tolerant inbred line CML323 and the drought-sensitive inbred line CB2-49-1 were screened by comprehensively evaluating D values. The drought-tolerant inbred line CML323 exhibits higher leaf relative water content, chlorophyll content, proline content, and ascorbate peroxidase and peroxidase activity while having lower malondialdehyde content, consequently demonstrating excellent drought tolerance. This study provides valuable insights into drought-tolerance indicators and reference materials for breeding maize varieties.

Systemic Lupus Erythematosus: An Overview of Pathogenesis, Prevalence, Diagnosis, Classification Criteria, Management, Challenges, and Future Directions

Systemic Lupus Erythematosus (SLE) is a complex, chronic autoimmune disease characterized by widespread inflammation and tissue damage across multiple organ systems. This paper aims to review the SLE pathogenesis, prevalence, diagnosis, classification criteria, management, challenges, and future directions. Scientific literature pertaining to SLE was analyzed through comprehensive searches in specialized academic resources, including PubMed and Google Scholar. This review explores the multifaceted nature of SLE, pathogenesis, which involves a complex interplay of genetic, environmental, and immunological factors leading to the loss of self-tolerance and autoantibody production. The epidemiology section highlights the varying incidence and prevalence of SLE globally. We review current diagnostic approaches, including clinical evaluation and laboratory tests, which are crucial for early and accurate diagnosis. The classification criteria, as outlined by established guidelines, are discussed to provide insight into the diagnostic framework used to identify and categorize SLE. SLE management is briefly addressed, including issues related to disease heterogeneity. Finally, we explore future directions in SLE research, focusing on emerging therapies. Despite advancements, the management of SLE remains challenging, necessitating ongoing research efforts to improve diagnostic precision, therapeutic efficacy, and patient outcomes.

Innovative solar PV array design: mitigating partial shading for Optimal Performance Index

Photovoltaic arrays are popular for green energy but suffer productivity loss from module faults and partial shading conditions (PSC). These two faults must be distinguished to avoid a permanent shutdown. Hence, this article presents two Novel 4 X 4 array structures with fewer tie-lines to address mismatch power loss under these abnormal conditions. The performances of these novel arrays are compared with Total-Cross-Tied (TCT), Honey-Comb (HC), and Bridge-Link (BL) under three PSC categories, with six cases falling into each category. PSCs are analysed at constant and varying temperatures, along with row and column module faults. Thirteen performance indices, including the Overall Performance Index (OPI), are addressed. The percentage reduction of tie-lines in novel topologies, along with their strengths and limitations, and variation of the performance indices of all the topologies are analysed. The obtained results reveal that the Novel-1 and Novel-2 arrays capture the global maximum power point (GMPP) in 67% and 78% of the analysed situations, respectively, outperforming standard arrangements and decreasing tie-lines. These findings support the efficacy and economic benefits of the novel array configurations, which provide considerable increases in PV system performance and reliability across a variety of environmental circumstances.

Assessment and Prediction of Health and Agricultural Impact from Combined PM2.5 and O3 Pollution in China

Combined PM2.5 and O3 pollution in China has caused negative health impacts on residents and reduced crop yields. The quantitative assessment and prediction of these impacts could provide a scientific basis for policy development. This study assessed the nationwide premature mortality, health effects, and crop damage attributable to PM2.5 and O3 pollution in 2019, and projected the associated health and agricultural losses under a business-as-usual (BAU) scenario for 2025. The economic benefits of improving air quality under different policy scenarios, including the 14th Five-Year Plan (FFP), Secondary Standard Limit (SSL), and Primary Standard Limit (PSL), were also explored. The results showed PM2.5 pollution in 2019 resulted in 246,000 all-cause premature deaths and the economic health loss was RMB 196.509 billion. Similarly, O3 pollution caused 186,300 premature deaths and the economic health loss was RMB 155.807 billion. O3 pollution has led to a loss of 28.5241 million tonnes of crop production and an economic loss of RMB 62.268 billion. Compared with 2019, the avoidable premature deaths from PM2.5 under different scenarios in 2025 were 50,600, 43,000, and 200,300 cases, respectively, exceeding the number of avoided premature deaths from O3 pollution. Compared with the BAU, reducing PM2.5 under different scenarios could generate economic benefits of RMB 70.178 billion, RMB 60.916 billion, and RMB 229.268 billion. Furthermore, the FFP scenario outperformed the SSL in mitigating winter wheat production losses caused by O3 pollution. These results provide important scientific support for the development and evaluation of future comprehensive pollution control measures for PM2.5 and O3.

Examining presenteeism and productivity losses among nursing workers: a cross-sectional study.

To characterize presenteeism and productivity losses among nursing professionals in public and private health services. A cross-sectional study was conducted with 123 participants from a public hospital and 159 from a private hospital in Manaus, Brazil. The Sociodemographic Health Questionnaire was utilized to assess presenteeism, while the Work Limitations Questionnaire measured productivity losses. Data were analyzed using non-parametric methods. Health-related work loss and presenteeism were reported by 50.41% of public sector professionals and 39.62% of private sector professionals. Despite this, presenteeism was more prevalent in the private sector (93.65%) compared to the public sector. Common health issues included musculoskeletal (26.49%), mental/behavioral (19.21%), respiratory (17.22%), neurological (16.56%), and gastrointestinal (5.96%) conditions. Additionally, 54.24% of private sector professionals and 44.23% of public sector professionals did not seek treatment. The private sector exhibited greater limitations in receiving care due to time management (40.34%), mental-interpersonal tasks (49.95%), production tasks (52.54%), and physical tasks (61.30%), resulting in higher productivity losses among nurses (13.46%) and nursing technicians (15.82%). High-complexity sectors demonstrated the greatest productivity losses. The study identified significant differences in the characteristics of presenteeism and productivity losses between nursing professionals in the public and private health sectors. These results point to the need to improve management and occupational safety and regulatory measures to solve workers' health problems and mitigate presenteeism and productivity losses in the public and private health sectors.

Estimating the cost for obstetric fistula repair in hospitals of Mozambique: a low-income country

BackgroundObstetric fistula is incident and prevalent in low-income countries. Globally, about 100,000 women develop fistula annually. In Mozambique, more than 2,000 fistulas are reported annually. A national strategy to combat obstetric fistula has been implemented in Mozambique from 2012–2020. This strategy is under review, making it opportune to generate evidence that reflects the course of the strategy implemented to subsidize/optimize the definition of priorities of the new strategy to achieve universal health coverage. In Mozambique, information on the costs incurred to treat fistula is scarce. This study aims to estimate the mean unit cost of repair/treatment of simple and complex obstetric fistula in Mozambique.MethodsWe carried out a retrospective evaluation, from the provider’s perspective, using the Ingredient and Stepdown approaches. The mean unit cost was obtained by the sum of individual and shared ingredients to treat fistula. Cost dimensions included Direct Medical Costs (personnel, drugs, and supplies), Overhead and Capital Costs (administration and capital assets’ costs, respectively). The average exchange rate was USD 1 = MZN 61.47. Data were collected in secondary, tertiary, and quaternary hospitals of Zambézia and Nampula provinces in 2021. Costs borne by patients and their families and loss of productivity were not included.ResultsThe mean cost for Simple Obstetric Fistula repair was MZN 14,937.21 (USD 243) and Complex Obstetric Fistula was MZN 21,145.68 (USD 344) per person operated. Regardless of the type of fistula, the repair cost was MZN 18,072.18 (USD 294).ConclusionWithout neglecting that prevention is better than plasty, the results show feasible levels of fistula repair costs for mobilization of funds. For the estimated 2,000 fistulas reported annually, the government needs an average MZN 36,144,360 (USD 588,000).

Combining cyclic lipopeptides and cinnamon extract enhance antifungal activity against Fusarium oxysporum strains pathogenic to banana and delay Fusarium wilt under greenhouse conditions

AbstractFusarium wilt of banana (FWB) caused by the soil-borne fungus Fusarium oxysporum f. sp. cubense (Foc) is a widely distributed disease that generates devastating losses in banana production. Foc belongs to the Fusarium oxysporum species complex (FOSC) which includes several evolutionary lineages. Nine of them are pathogenic to banana such as F. phialophorum, F. grosmichelli, F. duoseptatum and the most aggressive F. odoratissimum tropical race 4 (TR4). No control method has been successfully implemented to manage FWB, then enhancing the potential of management approaches can avoid or delay disease epidemics and reduce disease severity. Here we determined the antifungal effect of different plant-based extracts against Foc in vitro, and whether the combination of cinnamon (Cinnamomum zeylanicum) extract and Bacillus tequilensis EA-CB0015 cyclic lipopeptides had an additive effect against different Foc lineages in vitro and against FWB in banana plants in greenhouse. We found, from 17 plant-based natural extracts, that cinnamon was highly active against Foc strain IB (race 1). Furthermore, cinnamon and cyclic lipopeptides inhibited different strains of various evolutionary lineages of Foc belonging to race 1 and TR4, and their combination increased in 1.4-fold the effect of the single extracts in vitro. Our results showed that soil concentration of F. odoratissimum TR4-II5 decreased by 1000-fold when treated with the combination of 488 mg L−1 cinnamon and 128 mg L−1 lipopeptides in a soil microcosm system after 5 days of incubation, followed by a partial population recovery after 21 days. In greenhouse experiments, the combination reduced external but not internal FWB symptoms, and cinnamon extract had a significant impact on internal plant symptoms. Taken together, the effect of cyclic lipopeptides with cinnamon extract on Foc supports their function towards delaying the effect of disease progression and suggests that the combination enhances the effect of the single extracts.

Trichoderma role as an essential plant growth promotion-a review

In the world, pest infestation is responsible for 70% or more of per cent losses in agricultural productivity, and mycopesticide can provide an alternative option to pest control option as an alternative to synthetic pesticides. Trichoderma is a genus of fungal species, and Trichoderma viride is one of the known fungal species in categories that exhibit biocontrol mechanisms since it is well-identified for 100% effectiveness in pest control. The mycelium of T. viride has shown its capabilities for the production of various types of enzymes, including cellulases and chitinase, with degradation capability for celluloses and chitin polymers, respectively. It is ubiquitous in nature. It is widely used for the management of crop diseases and is basically soil-borne, but it is also foliar. Trichoderma has shown its potential due to diversity, ecology, and application. The mechanism of action includes competition, production of different metabolites, induced resistance and enzymes, etc. There are several commercial formulations available all over the world that are used against crop diseases. Trichoderma, due to its potential for degradation capability, can be utilised from waste to wealth. Later on, with the development of more research on Trichoderma, various utilities were found. This includes its effective control against harmful insects in agricultural as well as health sectors. It also can detoxify the heavy metals. In the health sector, continuous exploration of its benefits for drug discovery is being done. As a whole, it can be considered soil gold and a promising future beneficial microbe.

Economic impact of COVID-19 on patients with type 2 diabetes in Kenya and Tanzania: a costing analysis

IntroductionCOVID-19 affected healthcare access, utilisation and affordability, especially for patients suffering from chronic diseases, including type 2 diabetes (T2D). This study measured the occurrence and magnitude of changes in healthcare...