Product Labeling Research Articles

Label Accuracy and Quality of Select Weight-Loss Dietary Supplements Sold on or near US Military Bases

Background/Objectives: Sixty-eight percent of service members are living with overweight or obesity, some who may not consult a healthcare provider when they decide to lose weight. Instead, they often turn to weight-loss dietary supplements for self-care solutions. The purpose of this case series study was to examine the label accuracy and quality of select weight-loss dietary supplements sold on or near US military bases across the country. Methods: Weight-loss dietary supplements (n = 44) were selected and purchased in GNCs, Exchanges, and Shoppettes across 12 military installations from March 2023 to January 2024. Liquid chromatography-mass spectrometry was used to verify the label accuracy according to the Supplement Facts listed ingredients and whether they contained any ingredients prohibited for use in the military. Product label claims were analyzed using the Operation Supplement Safety (OPSS) Risk Assessment Scorecard. Results: Thirty-six products (82%) had inaccurate labels. Twenty-seven (61%) had ingredients listed on the label not detected through analysis. Sixteen products (36%) contained hidden ingredients. The four products purchased within one mile from the base listed multiple prohibited ingredients on the labels, with all detected. Forty (91%) products scored a “no-go” according to the OPSS Scorecard and none contained a third-party certification seal on the label. Multiple stimulants were included in products such that the product safety was unknown. Conclusions: The majority of weight-loss dietary supplements analyzed in this case series study had inaccurate labels and were considered a “no-go” according to the Scorecard. Service members should only have access to safe, high-quality dietary supplement products. OPSS is collaborating with the Department of Defense stakeholders to determine the most effective ways for service members to have access to third-party certified products on all military establishments.

Experiences and challenges in the development of carbon footprinting in megacities - taking Shanghai as an example

Using Shanghai as a case study, this article discusses the practices and methods of carbon footprint measurement in megacities, analyzing its evolution and significance in supporting densely populated megacities worldwide to achieve carbon neutrality. The study emphasizes thorough greenhouse gas emission accounting in high-density urban areas characterized by intensive economic activity and population concentration. Globally, nations, including China, are enhancing carbon management strategies by introducing new standards under the regulatory guidance of organizations such as the National Development and Reform Commission. However, notable obstacles remain, including the lack of a centralized database, insufficient product-specific approaches to managing emissions, and the absence of standardized certification systems for labeling products based on their environmental impact. To address these challenges, Shanghai is promoting a low-carbon transition across industries and encouraging the city's green development by fostering a collaborative industrial framework. This includes the CN100 program, which mobilizes leading companies to reduce the carbon footprint of supply chains and industrial processes.

Analysis of the Interactive Game Between Manufacturers and Retailers Considering the Free-Riding Effect on the Internet

Against the backdrop of an increasingly sound supply chain system and thriving e-commerce, it is becoming increasingly common for retailers to introduce their own brands of products and for manufacturers to open up direct online sales channels. The existence of these two supply chain decisions is complex and involves interactions. Moreover, the introduction of online direct sales channels will bring about differences in prices and service quality between channels, resulting in a free-riding effect on the internet. However, existing related research rarely considers the role of network free-riding effect in this supply chain system. This article integrates the network free-riding effect into the supply chain model by setting the network free-riding rate. According to whether retailers introduce their own brand products and manufacturers open up online direct sales channels, four supply chain scenarios are formed, and the reverse recursion method is used to obtain the profit functions for each of these four scenarios. Then, a Stackelberg game model is established to determine the response strategies of manufacturers and retailers based on the changes in profits of manufacturers caused by retailer decisions and the changes in profits of retailers caused by manufacturer decisions. Through analysis, it was discovered that a key factor affecting decision-making within the supply chain system is the retailer’s channel advantage. When the channel advantage of retailers is strong, manufacturers will open up online direct sales channels to weaken the channel advantage of retailers. Retailers will not introduce their own brand products but are more inclined to cooperate with manufacturers. When the channel advantage of retailers is weak, retailers will attract consumers and consolidate their channel advantage by introducing high-quality, low-priced private label products, while manufacturers will maintain cooperation with retailers and adopt a strategy of not opening up online direct sales channels. We also analyzed the Nash equilibrium state under different channel advantages of retailers.

Assessing Compliance: Violations of WHO Code in Breast Milk Substitute Marketing, Ecuador.

Breast milk substitute (BMS) marketing significantly influences global infant feeding practices. Ecuador, like many countries, seeks to regulate these promotions under the WHO's International Code of Marketing of Breast-Milk Substitutes. This cross-sectional analysis assessed BMS marketing compliance with WHO's Code in Ecuador. Surveys were conducted with mothers (n = 330) and healthcare professionals (n = 66), complemented by observations at health facilities (n = 33) and retail outlets (n = 44). Media monitoring and product labelling evaluations were also conducted. The study revealed widespread exposure to BMS marketing outside health facilities (91.21% of mothers). Promotional activities targeted healthcare professionals, with significant interactions involving free supplies (26.09%) and gifts (21.74%). Retail outlets prominently displayed BMS promotions, often featuring discounts (95%). Compliance with labelling criteria was notably low, particularly concerning nutrition and health claims (39%). TV emerged as the dominant platform for BMS advertising, with 2884 ads aired over 16 h and 24 min, totalling $1,876,915.50 in expenditures. Digital platforms also featured BMS ads, with significant engagement on social media (533,845 interactions). This study reveals widespread violations of the WHO Code in Ecuador, emphasizing the need for stronger regulations and targeted education for healthcare professionals and the public to protect infant health and promote breastfeeding. Despite existing regulations, the pervasive advertising and substantial investment in BMS marketing across various media underscore significant enforcement gaps. To effectively safeguard maternal and child health, Ecuador must fully incorporate and rigorously enforce all Code recommendations within its national legislation.

Implication of Characteristic-Based Adoption Model to Private Label Product in Malaysian Hypermarket

The rise of private label products has reshaped retail landscapes globally, challenging the dominance of national brands across various sectors, particularly in fast-moving consumer goods and groceries. While PLs have gained substantial market share in regions like Europe and North America, their adoption in developing markets, such as Asia, remains limited. Attempts to replicate European PL success in Asia have often faltered, highlighting the need for tailored approaches to navigate unique market dynamics. Fong and partners proposed a characteristic-based adoption model specifically for PL products in Malaysian hypermarkets, emphasizing the importance of understanding consumer responses through the perspective of Diffusion of Innovation theory. This study aims to explore the implications of Fong and partners’ model in Asian hypermarkets, offering insights to enhance PL market share. By examining the applicability of this model in the Malaysian context, this research contributes to a deeper understanding of PL adoption dynamics in developing markets and informs strategies for retailers to compete effectively in these environments.

Enhancing Brioche Bread with Emulsified Seed and Nut Oils: Nutritional and Sustainable Benefits

This study evaluates the effectiveness of an oil-in-water emulsion formulated from water and seed and nut oils as a substitute for butter in the formulation of brioche bread. First, the selected oils were physicochemically characterized. In the brioche, animal fat was fully and partially replaced, and the effects were analyzed at the physical, chemical, and sensory levels. The new formulations exhibited increased lightness, a softer crumb, improved cohesiveness, and greater expansion compared to the control, resulting in fluffier and lighter brioches. Nutritionally, the seed and nut oil brioches showed a lower fat content and lower energy value, but higher protein and carbohydrate levels. The lipid profile was enhanced, with a higher proportion of unsaturated fatty acids, which positively impacted two heart-friendly indices and increased the vitamin E content. This improvement potentially allows the food industry to apply health claims to product labeling. Regarding sensory analysis, in all cases, the reformulated brioches scored higher than the control sample in terms of external appearance, although there remained a preference for the flavor and aroma of the traditional version, which could be mitigated by adding flavor compounds such as diacetyl. This study differs from previous research by using a seed and nut oil emulsion instead of non-emulsified oils, improving the texture and stability of brioche bread, an achievement not consistently reported in prior studies. Additionally, it emphasizes sustainability by offering a plant-based alternative that addresses the growing consumer demand for vegan and eco-friendly products while providing enhanced nutritional benefits that support potential health claims.

Implementation of Halal Certification on Imported Agricultural Food Products and Their Relation to International Trade

Abstract Introduction to the Problem: Import activities are strongly related to international trade that one of the objectives is to meet the needs of a country. Indonesia carries out import activities on processed food products and agricultural products in order to fulfill food needs. To protect Indonesian consumers who are predominantly Muslim, Indonesia has passed legislation regarding halal certification and labeling through Law Number 33 of the year 2014 concerning Halal Product Assurance. Purpose/Study Objectives: The problems studied in this study include: (1) How is the implementation of Law Number 33 of 2014 concerning Halal Product Assurance in Halal certification and labeling of imported processed food products and imported agricultural products in Indonesia and (2) How is harmonized Law Number 33 of 2014 concerning Halal Product Assurance, especially on halal certification and labeling of imported processed food products and imported agricultural products in Indonesia related to the Technical Barriers to Trade agreement?. Design/Methodology/Approach: The research method used is juridical-normative with the data sources obtained in the form of primary legal materials in the form of laws and regulations, GATT 1994, and the TBT Agreement, secondary legal materials including legal books and journals, and tertiary legal materials, such as legal dictionaries. Findings: The implementation of Law Number 33 of 2014 has changed the provisions regarding halal certification and labeling of products circulating and traded in Indonesia, including imported processed food products and imported agricultural products, to become mandatory. The conformity of the Law Number 33 of 2014 which is included in technical regulations with the TBT Agreement is an urgency to ensure that national regulations and/or policies do not become obstacles in international trade. Paper Type: Research Article.

High-Performance Liquid Chromatography with DAD Detection for the Determination of Cannabinoids in Commercial Veterinary CBD Oil

The study highlights the need for quality control in evaluating medicinal plant products, especially CBD oils, before market release. Due to varying regulatory requirements, product labeling can sometimes be misleading, especially regarding cannabinoid concentrations such as CBD and THC. This research focused on developing a validated high-performance liquid chromatography (HPLC) method for accurately identifying and quantifying key cannabinoids in Commercial Veterinary CBD Oil. The main compounds identified included Cannabidivarin (CBDV), Cannabidiolic Acid (CBD-A), Cannabigerolic Acid (CBG-A), Cannabigerol (CBG), Cannabidiol (CBD), Tetrahydrocannabivarin (THCV), Cannabinol (CBN), ∆9-Tetrahydrocannabinol (d9-THC) ∆8-Tetrahydrocannabinol (d8-THC), Cannabicyclol (CBL), Cannabichromene (CBC), and Tetrahydrocannabinolic Acid (THCA), determined in line with the International Conference on Harmonization’s (ICH) guidelines. The method was validated for linearity, accuracy, precision, limit of detection (LOD), and limit of quantitation (LOQ). It was determined to be linear, with a correlation coefficient (R²) > 0.999. The LOD and LOQ values calculated from the calibration curve ranged from 0.05 to 0.13 and 0.50 to 0.61 µg/mL, respectively. The method also exhibited acceptable precision, with relative standard deviation values lower than or equal to 2%. The method’s accuracy was assessed through recovery percentages and fell within an acceptable range of 98–102 if the RSD was 2%. This study’s rigorous methodology and comprehensive findings significantly contribute to cannabinoid analysis. This validated protocol was used to analyze cannabinoids in 14 commercial veterinary CBD oil products from the Republic of North Macedonia. The performance parameters demonstrated that the method is reliable for quantitatively measuring cannabinoids in CBD oil. The analysis showed that the cannabinoid levels in the products were consistent with the manufacturers’ declared specifications, with no significant discrepancies in labeling.

Addressing the commercial determinants of menstrual health: a call to regulate menstrual product manufacturers.

Over the last two decades, menstrual health and hygiene have become increasingly common on the global health agenda. While governments and international organizations are adopting measures to make menstrual products more accessible, corporate actors producing them have only been subject to limited scrutiny. Yet, their products and commercial practices raise environmental, health, equity and societal issues, which warrant attention and regulation. As such, commercial disposable menstrual products are largely made up of plastic, sometimes as much as 90%. Menstrual pads and tampons also contain some chemicals, the health impact of which is still unclear. In addition, these products are often sold with high-profit margins, and marketing campaigns to sell such products tend to reinforce shame and secrecy. So far, no global standards exist to regulate menstrual products and manufacturers, and evidence in the field of menstrual health and hygiene is lagging behind. To fill this gap, countries have started to regulate menstrual products and the International Standards Organization is in the process of developing global standards to better regulate the content and labeling of menstrual products. To support the emergence of regulation in this area, this article conceptualizes for the first time a comprehensive framework for the regulation of menstrual product manufacturers. This framework encompasses five complementary measures to regulate the content; labeling; production and waste management; pricing; advertising and marketing of menstrual products. The article also calls for more research to produce evidence and for increased governmental and inter-governmental attention to menstrual product manufacturers.

Regulatory Impact of Selected U.S. FDA Postmarketing Safety Registries Conducted for Drugs Used to Treat Inflammatory or Autoimmune Conditions.

Assess the regulatory impact of selected FDA postmarketing safety registries on drug product labeling updates. Postmarketing safety studies were identified in internal record repositories for the Center for Drug Evaluation and Research, U.S. FDA, in March and September 2021. Studies eligible for review included prospectively enrolling patient registry studies conducted to assess the safety of drug products used to treat inflammatory or autoimmune conditions. These studies were requested between 1999 and 2011. This paper analyzed 10 safety (non-pregnancy) registries and four pregnancy registries (n = 14). Only four safety registry studies were successful in reaching their targets for both patient enrollment and patient follow-up or drug exposure. These registries were either multi-center, multinational studies or studies using participants from a health insurance or health maintenance organization. None of the safety registries led to safety labeling updates, regardless of targets' achievement for study enrollment and follow-up: six did not detect a new safety signal and four provided inconclusive results. Two pregnancy registries reached their targets for patient enrollment, and all four resulted in safety labeling updates, as required by the Pregnancy and Lactation Labeling Rule guidance. While six non-pregnancy registries did not detect a new safety signal, four did not produce safety results considered sufficiently robust to warrant specific regulatory action including safety-related labeling updates. The lack of safety signal detection in these observational studies should not imply the absence of safety signals. Appropriately designed, prospective, randomized controlled safety studies are the most reliable way to obtain interpretable safety data.

Biological Activities and Phytochemical Constituents in the Stimulatory Potential of Tithonia diversifolia Fermented Extracts: A Review

The world food production must increase by 70% to feed this massive population through the use of chemical inputs in the new millennium. Crop culture is challenged by parasitic constraints, seedlings unavailability and soil fertility issues, which can severely reduce productivity. However, the repeated uses of chemical inputs negatively impact environment, plant and human health equilibrium. So, pathogen resistance, seedling quality and plant fertilization are severely concerned over the course of time. In this context, the use of a plant extract as Tithonia diversifolia, could be a good natural alternative to chemical inputs stimulants. The lack of knowledge of phytochemical constituents involving biologicals activities in liquid form of T. diversifolia extract, need to be improved to ensure their labeling. This study reviews biological activities and main phytochemical constituents in the stimulatory potential of T. diversifolia fermented liquid extracts. The stimulatory potential bio-efficacy of T. diversifolia extracts concerns the combination of biocontrol and green fertilizer effects. The green manure is conducted by watering or mulching on varied crops, such as rice, maize or plantain banana. Existing concerns are to expand the information amounts concerning the stimulating properties of the bioactive compounds contained in the fermented liquid extracts. It would be a key to fully demonstrate their effectiveness in stimulating the mechanism of plant growth and the protection against phytopathogens. However, this review updates on the challenge of the possibility to characterize the major bioactive compounds in the extracts. The other challenge of this current work is to suggest an eco-responsible and biological labeling product based on T. diversifolia fermented liquid extract.

AUDIT AND QUALITY CONTROL OF FOOD PRODUCTS IN EU COUNTRIES AND THE WORLD

The article examines regulatory legal acts and other documents and literary sources regarding state control of food safety and quality in Great Britain, Germany, France, the USA and Japan. The health of every nation largely depends on the quality and safety of food products. In any country, at the state level, requirements for product safety and quality are regulated and their compliance is ensured. One of the methods of such provision is state control. The article analyzes the practices of controlling the quality and safety of food products in the USA, Germany, France, Great Britain and Japan. It was revealed that there are both common and special rules in the practice of controlling the quality and safety of food products in the studied countries. In all countries, control over the quality and safety of food products is carried out by state bodies. In all countries, during control, special attention is paid to the reliability of product labeling. Improper labeling entails banning the sale of products, removal from circulation or destruction of particularly dangerous products, and even criminal liability in France and the USA. The main responsibility for dangerous food products in all countries is borne by the manufacturers or suppliers of the products who put them into circulation. In the USA and Japan, information about the presence of allergens in a food product must be included in the labeling. In the USA, in order for the manufacturer's products to be able to be supplied for a government order, the enterprise must implement a quality management system in accordance with the requirements of ISO 9001, and in Japan, in order to obtain a permit for the manufacture of food products, it is necessary to prove that proper sanitary and hygienic control is ensured by implementing HACCP system. In Germany, Great Britain, and Japan, quality and safety control is entrusted to local self-government bodies. In Germany, there is a product safety monitoring program throughout the territory, which makes it possible to monitor the appearance of dangerous products on the market, as well as to check the effectiveness of the established MPC of dangerous substances. The presence of "passports" for ready-made food products is checked only in France, although such a document is mandatory in EU countries. In France and Japan, exceptional importance is attached to the education of schoolchildren on food safety issues.

CREMES COSMÉTICOS MANIPULADOS COM VITAMINA C: UMA ANÁLISE QUANTITATIVA

CREMES COSMÉTICOS MANIPULADOS COM VITAMINA C: UMA ANÁLISE QUANTITATIVA

Opioid antagonists: clinical utility, pharmacology, safety, and tolerability.

Opioid antagonists block opioid receptors, a mechanism associated with utility in several therapeutic indications. Here, we review the sites of action, clinical uses, pharmacology, and general safety profiles of US Food and Drug Administration (FDA)-approved opioid antagonists. A review of the literature and product labels of opioid antagonists was conducted. The unique clinical uses of approved opioid antagonists are related to their ability to block opioid receptors centrally and/or peripherally. Centrally acting opioid antagonists treat opioid and alcohol use disorders (AUDs) and reverse opioid overdose. Because the opioid system influences weight and metabolism, one opioid antagonist combination product is approved for chronic weight management; another, approved for adults with schizophrenia or bipolar I disorder, mitigates olanzapine-associated weight gain. Peripherally acting opioid antagonists are approved for opioid-induced constipation; another accelerates gastrointestinal recovery after bowel surgery. Opioid antagonists are generally well tolerated; they are not associated with physiologic dependence or abuse. However, opioid antagonists can precipitate acute opioid withdrawal in patients using or undergoing withdrawal from opioid agonists. Likewise, their use can confer a risk for opioid overdose if attempts are made to overcome opioid antagonist blockade of opioid receptors via the intake of additional opioids. Opioid receptor antagonists have diverse therapeutic benefits based on their respective pharmacology and sites of action; understanding their respective nuances facilitates the safe and effective use of these agents.

Customer Perception Towards Pharmaceuticals' Private Labels in Malaysia: Extending DOI Integrated Framework

In recent years, Malaysia's pharmaceutical sector has experienced substantial changes, most notably the emergence of a thriving private label market in response to shifting users’ preferences and market dynamics. Product labels, which are alternatively referred to as store brands or own labels, pertain to items produced or procured by a retailer for sale under its own brand. Private labels provide consumers with cost-effective alternatives to branded pharmaceuticals, while still offering the assurance of comparable efficacy and quality. Despite the increasing use of private labels in the pharmaceutical business, there is still a lack of understanding about customer perception towards these products in Malaysia. This concept paper aims to address the research gap in Malaysia by thoroughly investigating the factors that influence the adoption of private label pharmaceutical products. This research uses an integrated conceptual framework from buyer perception models and innovation adoption theories to explain the complex relationships between information, relative advantage, compatibility, risk and complexity, and intentions to adopt in retail pharmacy brands. By taking a holistic approach, we want to gain a deep understanding of consumer perception of pharmaceutical private labels across disciplines. The study strives to accomplish these goals by building a complete knowledge of the determinants that effect buyers’ conduct with regard to pharmaceutical private labels in Malaysia. Furthermore, it intends to provide pharmaceutical industry stakeholders with knowledge that can be utilized to formulate efficacious marketing approaches and strengthen consumer confidence in private label products.

Obesity as a medical and social problem

The article is a brief review of the relevant scientific literature published in the PubMed database in 2004–2024 on the epidemiology, etiology, treatment and prevention of obesity. The description of the key risk factors for the development of obesity is given, among them genetic factors, family history, psychological causes, and anesthetic marketing. The data on modern approaches to the treatment of obesity, including adherence to a low-calorie diet, adequate physical activity, taking medications that reduce appetite, enhance the feeling of satiety and reduce fat metabolism, are presented. It is noted that it is necessary to implement measures that lie outside the competence of medical organizations, such as ensuring the availability of healthy food and limiting the availability of fast food, changing the formulation of high-calorie products, labeling products and educating the population.

A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for avatrombopag

Avatrombopag is a next-generation thrombopoietin receptor agonist approved for the treatment of thrombocytopenia in patients with chronic liver disease scheduled to undergo surgery and thrombocytopenia in patients with chronic immune thrombocytopenia. However, realistic data on its post-marketing long-term safety and tolerability in large sample populations are incomplete. The adverse event (AE) reports of avatrombopag were analyzed based on the FAERS database. By extracting large-scale data from the FAERS database, this study used various signal quantification techniques such as reporting odds ratios, proportional reporting ratios, Bayesian confidence propagation neural network, and multi-item gamma Poisson shrinker to calculate and evaluate the ratio and association between avatrombopag and specific AEs. In the FAERS database, data from the second quarter of 2018 to the fourth quarter of 2023 were extracted for this study, a total of 1217 avatrombopag-related AEs reports were included for analysis. Based on four calculation methods, this study identified and 32 preferred terms associated with avatrombopag. Common AEs in the product label such as thrombosis, headache, contusion, petechiae, and gingival bleeding were detected. AEs not mentioned in the product label, such as photopsia and ear discomfort were also detected. The first 30 days after initiation of medication were the most common period for both serious and non-serious AEs. This study demonstrates the common AEs and the potential AEs associated with avatrombopag in real-world practice, which could provide valuable cautionary evidence for clinicians and pharmacists to manage safety issues with avatrombopag.

Quantifying protein kinetics in vivo: Influence of precursor dynamics on product labeling.

Protein kinetics can be quantified by coupling stable isotope tracer methods with mass spectrometry readouts; however, inter-connected decision points in the experimental design affect the complexity of the workflow and impact data interpretations. For example, choosing between a single bolus (pulse-chase) or a continuous exposure protocol influences subsequent decisions regarding when to measure and how to model the temporal labeling of a target protein. Herein, we examine the merits of in vivo tracer protocols, we direct attention towards stable isotope tracer experiments that rely on administering a single bolus since these are generally more practical to use as compared to continuous administration protocols. We demonstrate how the interplay between precursor and product kinetics impacts downstream analytics and calculations by contrasting fast vs slow turnover precursors (e.g. 13C-leucine vs 2H-water, respectively). Although the data collected here underscore certain advantages of using longer lived precursors (e.g. 2H- or 18O-water) the results also highlight the influence of tracer recycling on measures of protein turnover. We discuss the impact of tracer recycling and consider how the sampling interval is critical for interpreting studies. Finally, we demonstrate that tracer recycling does not limit the ability to perform back-to-back studies of protein kinetics. It is possible to run experiments in which subjects are used as their own controls even though the precursor and product remain labeled following an initial tracer dosing.

Navigation literacy of primary health care personnel (using the example of the heads of medical and obstetric centers in Orenburg region)

Objective. To assess navigation literacy of primary health care personnel (using the example of the heads of medical and obstetric centers in Orenburg region). Materials and methods. Navigation literacy of primary health care personnel was assessed among all heads of medical and obstetric centers in Orenburg region (n = 58). For this purpose, a single-stage continuous online survey was conducted using a combined questionnaire developed by the Central Research Institute for Healthcare Organization and Informatization of the Ministry of Heath of the Russian Federation. Results. The level of navigation literacy among the heads of the medical and obstetric centers of Orenburg region in 65.7 % of cases was excellent and sufficient. In the list of navigation skills, the heads of the medical and obstetric centers noted difficulties in the implementation of: issues of medical insurance (48.3 %), legal aspects of medical care and protection of patients' rights (27.5-48.3 %), healthcare reform (36.2 %). It was found out that from 63.7 % to 91.4 % of the heads of the medical and obstetric centers are aware of the ongoing state measures in the field of public health. The majority of the respondents (60.0 %) noted that they search for necessary information for professional purposes using digital tools. However, every third respondent (32.7 %) mentioned the difficulties in finding it on legislative issues, interpreting the quality and safety of food products according to their product labeling (27.6 %), solving problems related to mental health and well-being (18.9 %). These data demonstrate the need to improve navigation literacy of medical and obstetric centers managers in the digital environment. Conclusions. The modern multilevel and multicomponent healthcare system is associated with the need to improve the navigation literacy of medical personnel. The data obtained determined the main directions for improving navigation literacy of the heads of medical and obstetric centers.

Cloud detection sample generation algorithm for nighttime satellite imagery based on daytime data and machine learning application

Highly accurate nighttime cloud detection in satellite imagery is challenging due to the absence of visible to near-infrared (0.38–3 μm, VNI) data, which is critical for distinguishing clouds from other ground features. Fortunately, Machine learning (ML) techniques can more effectively leverage the limited wavelength information and show high-accuracy cloud detection based on vast sample volume. However, accurately distinguishing cloud pixels solely through thermal infrared bands (8–14 μm, TIR) is challenging, and acquiring numerous, high-quality and representative samples of nighttime images for ML proves to be unattainable in practice. Given the thermal infrared radiation transmission process and the fact that daytime and nighttime have the same source of radiance in TIR, we propose a sample generation idea that uses daytime images to provide samples of nighttime cloud detection, which is different from the traditional sample construction methods (e.g., manually label, simulation and transfer learning method), and can obtain samples effectively. Based on this idea, nighttime cloud detection experiments were carried out for MODIS, GF-5 (02) and Himawari-8 satellites, respectively. The results were validated by the Lidar cloud product and manual labels and show that our nighttime cloud detection result has higher accuracy than MYD35 (78.17%) and the ML model trained by nighttime manual labels (75.86%). The accuracy of the three sensors is 82.19%, 88.71%, and 79.34%, respectively. Moreover, we validated and discussed the performance of our algorithm on various surface types (vegetation, urban, barren and water). The results revealed that the accuracy of the three sensors over barren was found to be poor and varied with surface types but overall high. Our study can provide a novel perspective on nighttime cloud detection of muti-spectral satellite imagery.