Breeding animals without the use of antibacterial drugs is a relevant branch of modern science, because the entry of national agricultural products into the foreign market provides for the antibacterial drugs absence in raw materials of animal origin. Therefore, in order to improve livability and productivity of animals, it is necessary to constantly monitor the resistance of their bodies, use antibacterial drugs more carefully and eliminate unnecessary or ineffective drugs completely. Thus, an important task facing the veterinary service of the Russian Federation is the complete elimination or reduction of the antibiotics use in animal breeding and the use of drugs that can replace antibacterial ones. We first studied the effect of heteropolysaccharides “raspol” and “gemiv” on broiler bodies. It is established that the used drugs allow eliminating the antibacterial drugs from the broiler ration. In the period of antibacterial drugs exclusion from the broiler preventive treatment scheme these prebiotics cause an increase in poultry gain, increase its livability and natural resistance, while the use of antibiotics in broiler control group negatively affects the body. Recommendations for the use of prebiotics raspol and gemiv in broilers, as an alternative to antibacterial drugs, are provided.