Production Costs Research Articles

Evidence-based practices on nanotechnology in wound treatment

Nanotechnology has revolutionized wound treatment by offering innovative solutions that accelerate healing, reduce infections, and promote tissue regeneration. This article reviews evidence-based practices regarding the use of nanotechnology in wound care, with a focus on antimicrobial nanoparticles, smart dressings, and regenerative scaffolds. Studies reviewed between 2010 and 2024 indicate that silver, zinc oxide, and gold nanoparticles are effective in combating antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), thereby preventing infections in chronic and acute wounds. Additionally, smart dressings equipped with embedded sensors have demonstrated the ability to monitor the wound environment, detecting signs of infection or inflammation and delivering drugs in a controlled manner. Another aspect addressed is the use of nanomaterial-based scaffolds, which mimic the extracellular matrix and promote cell proliferation, facilitating tissue regeneration in hard-to-heal wounds, such as diabetic ulcers and severe burns. Although the results are promising, the article highlights the need for more large-scale clinical trials and long-term studies to assess the safety and efficacy of these technologies across diverse populations. Moreover, the high cost of some nanotechnological products remains a challenge for widespread implementation, particularly in resource-limited healthcare systems. The conclusion is that nanotechnology holds great potential to transform wound care, but its broad adoption will depend on further studies, improved accessibility, and greater awareness among healthcare professionals and patients.

Privatization in mixed duopoly with vertical differentiation: Price versus quantity competition

AbstractIn this paper, we investigate the issue of privatization in a mixed duopoly with vertical differentiation under Cournot and Bertrand competition. The public firm is assumed to produce a lower‐quality product with lower production costs. We find that under both Bertrand and Cournot competition, privatization is socially desirable (undesirable) if the quality level of the private firm is sufficiently high (low). However, if the quality of the private firm is intermediate, Bertrand and Cournot competition yields opposite policy implications: privatization is desirable under Bertrand competition while undesirable under Cournot competition. Therefore, under Bertrand competition, privatization is more likely to be welfare‐improving than under Cournot competition.

Multi-objective optimisation of ORC–LNG systems using the novel One-shot Optimisation method

Optimisation is drawing more and more attention in the organic Rankine cycle (ORC) research field. However, as the complexity of the ORC scenarios increases, it poses challenges on operational parameter, working fluid, and configuration optimisation levels. This work first proposes an improved optimisation method, termed the One-shot Optimisation (OSO) method, which can simultaneously optimise the working fluid and configuration. Then, a two-objective optimisation is performed using the OSO method in combined ORC–LNG systems, considering up to eight operational parameters, 11 working fluids, and 16 system configurations to maximise energy efficiency and minimise the electricity production cost (EPC). Finally, the result of the optimisation is divided according to the thermodynamic weight (W1), and two typical conditions are analysed in detail: the maximum case (W1 = 1) and the balanced case (W1 = 0.5). The results show that the OSO method is capable of identifying the optimal working fluid and optimal configuration within a single optimisation process. The basic ORC configuration is preferred when W1 is lower while the recuperative ORC is preferred when W1 is higher. The balanced case can achieve an energy efficiency comparable to that of the maximum case but with a significantly lower EPC. The balanced case can achieve as much as 87. 48% of energy efficiency, requiring only 19.77% of the EPC compared to those of the maximum case.

Innovations and Challenges in Semi-Transparent Perovskite Solar Cells: A Mini Review of Advancements Toward Sustainable Energy Solutions

Amid the shift away from fossil fuels, third-generation perovskite solar cells (PSCs) have become pivotal due to their high efficiency and low production costs. This review concentrates on semi-transparent perovskite solar cells (ST-PSCs), highlighting their power conversion efficiency (PCE) and average visible transmittance (AVT). We address strategies to optimize ST-PSC performance, tackling inherent challenges, such as optical losses from reflection, parasitic absorption, and thermalization loss, which impact the operational efficiency under variable environmental conditions. ST-PSCs are distinguished by their lightweight, flexible, and translucent properties, allowing for diverse applications in urban building integration, agricultural greenhouses, and wearable technology. These cells integrate seamlessly into various settings, enhancing energy harnessing without compromising on aesthetic or structural elements. However, the scalability of ST-PSCs involves challenges related to stability and efficiency in large-scale deployments. The tropical urban landscape of Singapore provides a unique case study for ST-PSC application, blending architectural aesthetics with high solar irradiance to optimize energy efficiency. While the potential for ST-PSCs to contribute to sustainable urban development is immense, significant technological hurdles must be overcome to realize their full potential. Continued advancements in material science and engineering are essential to address these challenges, ensuring the scalability and long-term deployment of ST-PSCs in global energy solutions.

Microbial Dynamics and Quality Monitoring in Biopharmaceutical Production

AbstractProkaryotic cells are pivotal in meeting the global demand for biopharmaceuticals. However, challenges such as the absence of advanced technology for real‐time monitoring, standardized testing methodologies, and quality risk assessment of microbial activity have led to increased production costs, delays, and shortages of biopharmaceutical products. A thorough understanding of how biomolecule production interacts with microbial population structure and function is vital for improving continuous manufacturing and process automation. In this review, we discuss the current microbiological techniques that meet good manufacturing practice requirements in industrial settings, explore the advantages of monitoring and measuring biomass growth efficiency and turnover rates beyond regulatory criteria for product release, and provide a critical assessment of the current state of knowledge on bioassays and engineering tools for biomolecule yield measurement and monitoring. Furthermore, we identify areas for future development, potential applications, and the need for interdisciplinary innovation to drive future research, including advancing bioassays for biopharmaceutical wastewater risk.

ANALISIS NILAI TAMBAH DAN OPTIMASI KEUNTUNGAN PRODUKSI OLAHAN KERANG KAMPAK (STUDI KASUS PADA UMKM BUNDA SURABAYA)

This research was conducted at UMKM Bunda Surabaya, Surabaya City, with a focus on value-added analysis and profit optimization of processed shellfish production. The research method used was a case study with non-probability sampling, and data collection through interviews, questionnaires, observation, and secondary data. Data analysis was carried out descriptively and quantitatively, including the calculation of production costs, revenues, and profits. The Hayami method was used to calculate added value, while the simplex method was used for production profit optimization. The results showed that Bunda Surabaya MSMEs earned profits from the production of shredded clams, clam sticks, and clam chili sauce, with a fairly high added value. The highest profit was obtained from the clam sauce product amounting to Rp. 775,201 per one production process. The added value of shredded clams is Rp. 94,726 per kg of raw material with a value-added ratio of 63.15%. This research is expected to provide benefits for the shellfish processing industry and improve the welfare of the fishing community.

Optimizing the Operation of an Electrolyzer with Hydrogen Storage Using Two Different Methods: A Trade-Off Between Simplicity and Precision in Minimizing Hydrogen Production Costs Using Day-Ahead Market Prices

The potential for hydrogen is high in industrial processes that are difficult to electrify. Many companies are asking themselves at what cost they can produce hydrogen using water electrolysis with hydrogen storage. This article presents a user-friendly and less computationally intensive method (called method 1 in the following) for determining the minimum of the levelized cost of hydrogen (LCOH) by optimizing the combination of electrolyzer size and hydrogen storage size and their operation, depending on electricity prices on the day-ahead market. Method 1 is validated by comparing it with a more accurate and complex method (called method 2 in the following). The methods are applied to the example of a medium-sized industrial company in the mechanical engineering sector with a total natural gas demand of 8 GWh per year. The optimized LCOH of the analyzed company in method 1 is 5.00 €/kg. This is only slightly higher than in method 2 (4.97 €/kg). The article shows that a very good estimate of the LCOH can be made with the user-friendly and less computationally intensive method 1. For further validation of the methods, they were applied to other companies and the results are presented below.

Valorizing Waste Streams to Enhance Sustainability and Economics in Microbial Oil Production.

Driven by demand for more sustainable products, research and capital investment has been committed to developing microbially produced oils. While researchers have shown oleaginous yeasts and other microbes can produce low-carbon footprint oils by leveraging waste streams as energy sources, previous analyses have not fully explored the quantity of available waste streams and in turn economy-of-scale enabled on capital and operating expenses. This paper makes parallels to 2G ethanol facilities, enabling a data-driven understanding of large-scale production economics. Production costs are broken down for a variety of scenarios. The analysis finds that reaching price parity with large-scale commodity oils (e.g., palm oil, high-oleic cooking oils, biofuels feedstock oils, lauric acid) is not possible today and unlikely even under aggressive future assumptions about strain productivity. Instead, commercial production must be targeted at end markets where sustainability-conscious consumers are willing to pay the price premiums identified in this paper.

Intelligent Optimization and Impact Analysis of Energy Efficiency and Carbon Reduction in the High-Temperature Sintered Ore Production Process

The coordinated optimization of energy conservation, efficiency improvement, and pollution reduction in the sintering production process is vital for the efficient and sustainable development of the sintering department. However, previous studies have shown shortcomings in the multi-objective collaborative optimization of sintering systems and the quantification of pollutant impacts. To address these, this paper proposes a multi-objective optimization method integrated with the NSGA-III algorithm and establishes an integrated system optimization model for sintered ore production and high-temperature waste heat recovery. The results demonstrate significant improvements: energy utilization efficiency increased by 0.67%, energy consumption decreased by 17.3 MJ/t, production costs were reduced by 11.45 CNY/t, and the emissions of CO2, SO2, and NOx were reduced by 0.464 kg/t, 0.034 kg/t, and 0.008 kg/t, respectively. Additionally, the study identified optimal configuration parameters and analyzed the quantitative impact of several key factors on multiple indicators. The results also show that reducing the water content of the mixture, decreasing the middling coal content in the fuel, and increasing the thickness of the material layer are effective strategies to reduce energy consumption and pollutant emissions in the sintering process. Overall, implementing these optimizations can bring significant economic and environmental benefits to the steel industry.

Availability and cost of gluten-free products in Algeria

PurposeA strict gluten-free diet (GFD) is the only effective treatment for coeliac disease (CD), which has an increasing prevalence. However, the limited availability and high price of gluten-free products (GFPs) compared to their gluten-containing counterparts (GCCs) are still among the factors that may influence compliance with a strict GFD. The purpose of this study is to assess the availability and price of GFPs in retail stores in a major Algerian city and investigate how they compare to GCCs.Design/methodology/approachWe performed a cross-sectional study that targets a representative number of supermarkets and grocery stores in Constantine (Algeria). All available GFPs as well as their GCCs were recorded. The price per 100 g was recorded for each product.FindingsAmong the 285 visited stores, only 25.4% of them sold GFPs, which were more available at supermarkets than at grocery stores. The category “gluten-free pasta and couscous” was the most represented (43.8%). A total of 64 GFPs were observed across 285 stores investigated, and their price was two to six times higher than that of their GCCs.Originality/valueThis study showed the limited availability and diversity and higher price of processed GFPs in Algeria. This negatively influences compliance with GFD as well as the quality of life of patients with CD. Furthermore, the findings prompt the national government to provide financial support to coeliac individuals.

Feasibility assessment of Low-Carbon methanol production through 4E analysis of combined cycle power generation and carbon capture Integration

This study evaluates the feasibility of producing methanol without carbon emissions Using a comprehensive 4E (energy, exergy, economic, and environmental) approach. Our study focuses on a single methanol production system, analyzing its efficiency, sustainability, and potential as a clean fuel production method so that focusing on capturing carbon dioxide from combined cycle power generation and using the generated power to produce hydrogen through ion exchange electrolysis. The systems were simulated using Aspen Plus software, considering practical constraints to align with the capacity of existing power plants. The analysis revealed that the studied methanol production systems can produce 65.3 MW of power, with a net production power of 65.2 MW available for sale to the national grid. The annual methanol production, based on 8,000 operational hours, is 46,086 tons. The cost of methanol production is estimated at $556.69 per ton, and the environmental impact rate was calculated at 0.3726 units, with an exergy efficiency of 31.63 %. The study demonstrates that methanol can be produced efficiently using carbon capture from combined cycles, significantly reducing carbon dioxide emissions. The results suggest that while the system involves high-cost equipment, it effectively balances power generation and methanol production with a relatively low environmental impact. Future research could focus on advanced exergy analysis to identify and mitigate sources of exergy destruction, as well as optimizing carbon capture configurations and integrating solar thermal energy to enhance system sustainability further.

Amorphous IrOx nanoparticles on N-doped carbon matrix islands for enhancing proton exchange membrane water electrolysis

The development of an electrocatalyst and electrode that maintain their integrity under a high current density is vital for the advancement of PEMWE. In this context, we develop amorphous iridium oxide (IrOx) anchored on an N-doped carbon matrix island, directly formed on titanium porous transport layer through a simple method consisting of spray coating and pyrolysis. Remarkably, this configuration achieves 10 mA/cm2 current density for oxygen evolution reaction (OER) in acidic electrolyte, with only a 240 mV overpotential required, and the durability of this structure is confirmed by long-term and accelerated stress tests. These merits enable the unit cell to achieve over 6 A/cm2 at 2 V cell voltage without considerable degradation. This catalyst fulfills the requirement of the US Department of Energy’s 2026 target in performance (> 3 A/cm2 at 1.8 V) and in energy efficiency (> 65 %), as well as in the electricity cost for H2 production (US $2.0/kg H2).

Cost and Return Analysis of Tomato Cultivation in Three Different Districts of Bangladesh

This paper attempts to analyze the costs, return and production problems of tomato in three districts namely Gazipur, Rangpur and Cumilla in Bangladesh. It is necessary to enunciate that through purposive sampling technique, the data were collected from 225 tomato cultivators of Cumilla and Rangpur districts. Human labour, fertiliser, bamboo sticks, thread, seeds and seedlings, ploughing, irrigation, insecticides and pesticides, hormone, etc. are all necessary for the production of tomatoes. Transport expenses must be taken into account as well. Together, the aforementioned elements were taken into account to estimate the cost of tomato production. Every data set was subjected to statistical and economic analysis, with validated outcomes via a series of tables. Numerous issues affect farmers, and this study sheds insight on this situation. The findings showed that the total cost was highest in Gazipur (Tk.333,800/ha) than that of Rangpur ( Tk. 304,600/ha) and Cumilla ( Tk.282,670/ha). Gross returns from tomato in Cumilla and Rangpur were Tk. 234,942/acre and Tk. 212,213/acre respectively. The net returns were found higher in Gazipur (Tk. 206,200/ha) than that of Rangpur (Tk. 135,400/ha) and Cumilla (Tk. 97,330/ha). Based on overall costs, the Gazipur, Rangpur and Cumilla districts' benefit cost ratios for tomato production per hectare were determined to be 1.60,1.40 and 1.30, respectively. The most notable limitations in were the high cost of inputs, the absence of storage facilities, price fluctuations, and damage from insects and diseases.

Digital twin-based cross-enterprise production-delivery synchronization in a highly dynamic environment

Efficient collaboration between production and logistics is crucial for timely order fulfillment and stable operations of system, necessitating closer cooperation between manufacturers and third-party logistics providers. However, achieving cross-enterprise synchronization presents three main challenges. First, concerns regarding information privacy and security lead to disjointed and non-shared resources. Second, the decision-making is not coordinated and consistent in dealing with dynamic interference. Third, differentiated strategies emerge as manufacturers and 3PLs employ different batch processing methods for customer orders in pursuit of economies of scale. This multifaceted disconnect leads to significant asynchronization in cross-enterprise production-logistics, resulting in inefficiencies and increased costs throughout the system. To address these challenges, this paper focuses on three key aspects: a digital twin-based cross-enterprise information-sharing framework, a cross-enterprise synchronized mechanism, and a collaborative optimization based distributed decision method. These aspects provide an intelligent production-logistics synchronization solution in the unique environment of Industry 4.0. Finally, through a case study of a paint enterprise, this paper comprehensively evaluates the differences in performance of the Production-Logistics Synchronization System (PLSS) under various synchronization modes. The results indicate that the proposed solution enhances the collaborative efficiency of production-logistics while ensuring the information security of the collaborating parties, effectively reducing production and delivery costs.

Identifying and Analysing Constraints in the Branded Rice Market: A Comprehensive Study of Stakeholders in Kerala, India

The study assessed the various constraints faced by the stakeholders in branded rice market in Kerala. These stakeholders include farmers, exporters, non-exporting private rice manufacturers, co-operative society, wholesalers, retailers and consumers. By examining the constraints across the branded rice market from production to consumption, the study aimed to identify the critical issues like, production constraints, procurement constraints, marketing constraints, institutional constraints export constraint and financial constraints. A sample of 30 farmers and one agent, five exporters and 10 non-exporters 20 wholesalers and 30 retailers and 120 consumers from Ernakulam and Palakkad districts were selected for the study. The study identified the major problems faced by the stakeholders of branded rice market by using Garret’s ranking method. Farmers were facing difficulties in rice production due to high input costs, high labour costs and untimely availability of water. Delay in procurement from SUPPLYCO and adequate facilities for drying and cleaning compel them to sell their produce in the open market. There was a communication gap between institutions and farmers. Lack of transportation facilities, high maintenance cost of machinery and financial difficulties were the major constraints faced by PADDICO. High transportation cost, high international trade barriers and price volatility were the major constraints faced by private manufacturers of branded rice. Heavy documentation & procedures was the major constraint faced by exporters. Lack of demand of branded rice was the major constraint faced by resellers. High price was the major constraint faced by the consumers. The high cost of production faced by farmers can be reduced by improved mechanisation in the rice cultivation. The study also recommended the suggestions for the constraints of other market stakeholders of branded rice market.

Utilising brewer’s spent grain as a cost-effective feed formula for sustainable house cricket (Acheta domesticus) rearing

Abstract This study investigates the potential of brewer’s spent grain (BSG) as a cost-effective alternative to soybean meal in the diets of house crickets (Acheta domesticus) to enhance sustainable cricket rearing. BSG, a by-product of the brewing industry, was chosen due to its local availability and high protein content (38%). Here, the impacts of varying levels of BSG substitution (0%, 10%, 20% and 30%) on the growth performance, nutrient utilisation, chemical composition, and volatile compound profiles of crickets over a 45-day period was assessed. Crickets were reared under controlled conditions and divided into five groups, each receiving one of the experimental diets. Growth performance parameters, including body weight, average daily gain, and feed conversion ratio, were measured. Chemical analysis of the crickets and their diets was conducted, focusing on protein efficiency ratio, apparent dry matter digestibility (ADMD), and nitrogen retention. Volatile compounds were identified using gas chromatography-mass spectrometry. Crickets fed BSG diets exhibited higher protein deposition and lower fat content compared to those on a commercial diet, suggesting BSG’s potential to improve protein quality while reducing fat accumulation. ADMD was also higher in BSG-fed crickets, likely due to the prebiotic effects of components such as β-glucans and arabinoxylans. Additionally, the inclusion of BSG up to 30% in cricket diets reduced production costs by up to 29% compared to a commercial diet. Volatile compound analysis revealed that crickets fed BSG diets produced different odour profiles, with 2-heptanone, a compound with a fruity aroma, detected only in BSG-fed crickets. These findings suggest that BSG is a viable and sustainable ingredient for cricket feed, offering both economic and nutritional benefits while also influencing the sensory characteristics of crickets. Further research is recommended to optimise BSG inclusion levels and explore its broader applications in insect and animal farming.

Exploring biodegradable alternatives: microorganism-mediated plastic degradation and environmental policies for sustainable plastic management.

Plastics offer versatility, durability and low production costs, but they also pose environmental and health risks due to improper disposal, accumulation in water bodies, low recycling rates and temporal action that causes physicochemical changes in plastics and the release of toxic products to animal health and nature. Some microorganisms may play crucial roles in improving plastic waste management in the future. Cunningamella echinulata has been identified as a promising candidate that remains viable for long periods and produces a cutinase that is capable of degrading plastic. Other recent approaches involving the use of microorganisms are discussed in this review. However, there does not seem to be a single science that is efficient or most appropriate for solving the problem of plastic pollution on the planet at present. Regulations, especially the implementation of different laws that address the entire plastic cycle in different countries, such as Brazil, the USA, China and the European Union, play important roles in the management of this waste and can contribute to reducing this problem. In the context of the transversality of the information compiled here, the current limitations are discussed, and an effective plan is proposed to reduce plastic pollution. Although it is challenging, it involves implementing legislation, promoting sustainable alternatives, improving collection and recycling systems, encouraging reuse, supporting research and technological innovation, promoting corporate responsibility, collaborating globally, raising public awareness, optimizing waste management and, above all, continuously monitoring the progress of actions based on measurable metrics.

Progress in Agronomic Crops Lodging Resistance and Prevention: A Review

ABSTRACTCrop lodging is recognised as one of the yield‐limiting factors in agricultural production. Therefore, better understanding to improve lodging resistance and to prevent lodging‐induced losses in agronomic crops is necessary. Besides yield losses, lodging severely affects the crop harvesting process and increases the production cost. However, achieving the objective of higher crop yields and yield quality without increasing lodging risk is quite challenging. To this end, it is essential to interpret the underlying mechanism of plant stem buckling and failure of root anchorage and optimise the fundamental trade‐off between lodging resistance and yield performance in agronomic crops. In the present review, we made an effort to discuss recent and innovative research insights that guarantee greater lodging resistance along with advanced lodging prevention strategies while sustaining higher crop yield and yield quality.

Wood and Wood-Based Materials in Space Applications—A Literature Review of Use Cases, Challenges and Potential

Current political and sociological efforts to respond to the need for more environmentally friendly technologies have inspired a revival of wood and wood-based material utilization in space systems. The popularity of these materials has faded since their widespread use in the early days of aerospace engineering. This work reviews the literature to provide an overview of use cases, the motivation for using wood and wood-based materials and the challenges involved. A small number of applications were identified in which wood and wood-based materials were preferred over non-renewable raw materials. They are mainly applied for less-stressed disposable components or as a thermal protection material. It can be shown that the applied wooden materials have advantages such as low production costs, easy availability, easy and environment-friendly decomposition and low weight. However, only a limited number of applications have achieved a high level of technological readiness so far. Properties such as anisotropy and a lack of uniformity, defects in wood, the quantity available material and a lack of standards for the certification of wooden materials represent challenges. These are addressed in the current research, which additionally focuses on sustainable growth, enhanced environmental friendliness and advanced lightweight design.

Research Progress in the Synthesis of N-Acyl Amino Acid Surfactants: A Review

This paper reviews the research progress in the synthesis of N-acyl amino acid surfactants, including chemical synthesis methods, enzymatic synthesis methods, chemo-enzymatic methods, and fermentation methods. Chemical synthesis is currently the main route for laboratory and industrial synthesis, including methods such as direct dehydration condensation of fatty acids, amidation of fatty acid anhydrides, carbonyl addition of fatty amides, amidation of fatty acid activated esters, amidation of fatty acid methyl esters, amidation of oils and fats, hydrolysis of fatty nitriles, and Schotten–Baumann condensation. Enzymatic synthesis has the advantages of mild reaction conditions and being green and pollution-free, but the yield is relatively low. The chemo-enzymatic method combines the advantages of enzymatic and chemical methods, but it has not been widely promoted. Fermentation methods have low production costs and are environmentally friendly but the technology is not yet mature. This paper elaborates on the principles, advantages, and disadvantages of each synthesis method and provides an outlook on future research directions.