Detection of periapical bone pathosis is an important part of the diagnostic process in dentistry. Xeroradiographs and E-speed films were taken to evaluate and to compare the diagnostic value for the radiographic interpretation of periapical lesions. Thirty-four patients undergoing endodontic treatment were chosen. Simultaneous exposures of the radiographic film and the xeroradiographic plates were made. The samples were viewed and categorized by the examiners using the following scores: 0 = unacceptably poor, 1 = poor but diagnostic, 2 = adequate for diagnostic information, and 3 = optimal for diagnostic information. A paired sample t test was performed on the result of the evaluation by the two examiners, and both showed that there were no significant difference at p < 0.05 between xeroradiography and conventional radiography. A two-sample t test was performed on the means of the two examiner's evaluation, and there was no significant difference at p < 0.05 between the means.