BackgroundArtificial Intelligence (AI) in dental diagnostics is evolving, offering innovative approaches for conducting cephalometric analysis with less manual input and overcoming the limitations of traditional imaging methods. To enhance the diagnostic processes in dentistry, an open-source software that utilises AI to improve the extraction of cephalometric values from limited field of view (FOV) images was created. Material and MethodsReduced FOV images lack several vital cephalometric landmarks, prompting the creation of predictive models to estimate missing values. The GridSearchCV algorithm and other algorithms were used to construct predictive models using software and to select the best models. The software was validated by comparing the predicted values with the actual measurements and calculating the mean squared error using Excel. Further validation involved a randomly selected cohort of 25 untreated orthodontic cases. ResultsEvaluation of the software showed that it was effective in accurately predicting key cephalometric measurements, suggesting that it could be a reliable tool for clinical use. However, some variations were noted in its predictive accuracy across different measurements, indicating areas that could benefit from further development. The software could align closely with the actual cephalometric measurements through detailed statistical analysis. ConclusionsThe integration of AI into cephalometric analysis with the software could represent progress, potentially leading to more efficient dental diagnostics and a reduction in the need for additional X-rays. This study aimed to advance the integration and refinement of AI in healthcare, focusing on minimising bias and understanding its impact on clinical decisions. In future studies, the application of AI in dental practice should be expanded to address these challenges. Clinical Significance StatementThis software integrates AI into clinical practice to enhance the diagnostic and therapeutic phases for patient benefit. It enables precise and comprehensive cephalometric analyses using data previously considered insufficient, thereby reducing the need for X-rays and improving patient care.