This study aimed to review the application of Process Oriented Guided Inquiry Learning (POGIL) in chemistry learning strategies by analysing reputable international journal documents between 2012 and 2022. The method used was a literature study with 47 articles on POGIL-based chemistry learning strategies. The results of the analysis showed that POGIL-based chemistry learning strategies applied to college students and high school students can improve learning achievement, self-efficacy, critical thinking, problem-solving, science processing skills, representational abilities, multiple intelligences and other skills. The chemical study materials were about basic chemistry, organic chemistry, physical chemistry, biochemistry and inorganic chemistry. In addition, several researchers used the POGIL syntax at different stages from the original idea of Moog and Spencer because the design of POGIL activities adapted to the skills to be improved. Furthermore, there are limitations to the application of POGIL-based chemistry learning strategies, which require more time to implement. Keywords: POGIL, chemistry, learning strategies